A method includes dispensing a liquid from a dispenser having a first piston channel and a first nozzle channel that is non-parallel to the first piston channel and is connected to the first piston channel at a first intersection. The dispenser includes a first piston configured to slide within the first piston channel; a first nozzle coupled with the first nozzle channel; a first valve located between a dispensing-liquid reservoir and the first intersection; and a second valve located between the first intersection and the first nozzle. Dispensing the liquid from the first dispenser includes pulling the first piston to initiate flow of a liquid in the dispensing-liquid reservoir to the first intersection; and subsequent to pulling the first piston, pushing the first piston to initiate flow of the liquid in the first intersection to the first nozzle so that the liquid is dispensed from the first nozzle.

Provided is a compound introduction apparatus including: a processing chamber; a first heater that introduces an introduction-target compound into a cell inside the processing chamber; a supply flow channel for supplying a cell suspension containing the cell and the introduction-target compound to the processing chamber; a discharge flow channel for discharging the cell suspension from the processing chamber; a second heater that prevents backflow of the cell suspension from the processing chamber into the supply flow channel; and a third heater that pressurizes the discharge flow channel.

An integrated system for processing and preparing samples for analysis may include a microfluidic device including a plurality of parallel channel networks for partitioning the samples including various fluids, and connected to a plurality of inlet and outlet reservoirs, at least a portion of the fluids comprising reagents, a holder including a closeable lid hingedly coupled thereto, in which in a closed configuration, the lid secures the microfluidic device in the holder, and in an open configuration, the lid is a stand orienting the microfluidic device at a desired angle to facilitate recovery of partitions or droplets from the partitioned samples generated within the microfluidic device, and an instrument configured to receive the holder and apply a pressure differential between the plurality of inlet and outlet reservoirs to drive fluid movement within the channel networks.

A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.

A device and method for fluorescent labelling a component is provided. The device comprising a first user-replaceable reservoir comprising a strongly buffered alkaline solution of aromatic ortho-dialdehyde dye, a second user-replaceable reservoir comprising a weakly buffered acidic solution of a reducing agent, one or more fluid pathways comprising the component, and a network of connection channels linking the reservoirs and the fluid pathway to enable the alkaline solution and the acidic solution to combine with the component in order to label the component by reacting the component with the alkaline solution and the acidic solution.

Microfluidic devices with microfluidic cassettes allow for on-cassette processing of nucleic acids including amplification by polymerase chain reaction. In systems and methods of using the microfluidic device, the microfluidic cassette is pressurised prior to amplification of nucleic acid in said sample in an amplification/PCR section of the device.

A sample preparation module accepts a sample including a target analyte. The sample preparation module processes the sample through several reaction chambers and a solid phase column. Different reagents are present in the reaction chambers. The eluted analyte is then transferred to the amplification module, where it is further processed and amplified for optical analysis.

An acoustic analyzer system is provided that includes an acoustic analyzer having a reusable glass flow cell positioned within the acoustic analyzer. A disposable card body may be inserted into the acoustic analyzer and deliver sample fluid to the glass flow cell so that acoustic-wave assisted measurements may be performed on the sample fluid. The disposable card body may also deliver wash fluid to the glass flow cell, and receive waste sample fluid and waste wash fluid from the glass flow cell to prepare the glass flow cell for subsequent sample fluids. Numerous other embodiments are provided.

A system for delivery of liquid to and removal of liquid from a sample is provided. The system includes a primary device that contains the sample and at least one valve configured to allow liquid to be delivered to and removed from the sample; at least one reservoir that is configured to receive a volume of liquid; a secondary device including at least one port configured to receive the at least one reservoir and configured to be coupled to the primary device; and a tertiary device configured to receive the secondary device and comprising mechanical modules that deliver the volume of liquid from the at least one reservoir to the sample and remove the volume of liquid from the sample. Positioning the primary device in the secondary device causes the volume of liquid in the at least one reservoir to be delivered to the sample contained within the primary device.

A washing device comprises a manifold dispenser comprising at least one liquid input and a plurality of liquid outputs that operably direct fluid to contact a plurality of laboratory consumables held by a rack in the washing device. A number of the plurality of liquid outputs being at least equal to a number of the plurality of laboratory consumables such that each liquid output of the plurality of liquid outputs operably directs the liquid at a corresponding laboratory consumable of the plurality of laboratory consumables.