Patent classifications
B04B1/12
Single use tubing set for making genetically modified donor cells for reinfusion into a patient
The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
Single use tubing set for making genetically modified donor cells for reinfusion into a patient
The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
Equipment and procedure for culturing, separating, and genetically modifying donor cells for reinfusion into a patient
The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
Equipment and procedure for culturing, separating, and genetically modifying donor cells for reinfusion into a patient
The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
Self-emptying separator for the gentle discharge of shear-sensitive products, and method for operating same
A self-emptying separator includes a rotatable drum with an inlet, a liquid outlet, outlet openings for solid material, and a control system. A flowable starting product is cleared of the solids in continuous operation in a centrifugal field in the rotating drum. A continuous discharge of a clear phase is performed. A solid phase is discharged via the outlet openings from a solids collecting space of the drum into an annular solids catcher. The solids catcher has a device for generating a fluid curtain against which the solids, issuing from the outlet openings for solid material, impact.
Self-emptying separator for the gentle discharge of shear-sensitive products, and method for operating same
A self-emptying separator includes a rotatable drum with an inlet, a liquid outlet, outlet openings for solid material, and a control system. A flowable starting product is cleared of the solids in continuous operation in a centrifugal field in the rotating drum. A continuous discharge of a clear phase is performed. A solid phase is discharged via the outlet openings from a solids collecting space of the drum into an annular solids catcher. The solids catcher has a device for generating a fluid curtain against which the solids, issuing from the outlet openings for solid material, impact.
SEPARATOR
A separator includes a housing that is stationary during operation and designed as a tank having at least two openings. A drum located inside the housing can be rotated about an axis of rotation, the drum having an axis of rotation and at least one opening. A gap is formed at least in sections or continuously between the drum and the housing. The separator also includes a support and drive device having at least two support and/or drive units, which keep the drum suspended inside the housing, supported, and/or set in rotation. One of the support and/or drive units is a first magnetic bearing that at least axially supports the drum and to keep it suspended. At least one other of the support and/or drive units is axially supports the drum.
SEPARATOR
A separator includes a housing that is stationary during operation and designed as a tank having at least two openings. A drum located inside the housing can be rotated about an axis of rotation, the drum having an axis of rotation and at least one opening. A gap is formed at least in sections or continuously between the drum and the housing. The separator also includes a support and drive device having at least two support and/or drive units, which keep the drum suspended inside the housing, supported, and/or set in rotation. One of the support and/or drive units is a first magnetic bearing that at least axially supports the drum and to keep it suspended. At least one other of the support and/or drive units is axially supports the drum.
Apparatus for producing potable water
The invention provides an apparatus for providing potable water, which apparatus comprises a plurality of components linked in series to provide a flow path through the apparatus, wherein the plurality of components comprises: (i) an inlet (4) for a stream of contaminated water requiring purification; (ii) a centrifugal separator (20) for separating the contaminated water stream into a partially purified water stream and a contaminant stream; (iii) a pre-filter pump (26); (iv) a pre-filter pressure sensor (30); (v) a first filter assembly (32) comprising one or more filter modules for removing particles of a predetermined size and/or removing organic contaminants from the partially purified water stream; (vi) a post-filter pressure sensor (38); (vii) a post-filter pump (40); (viii) a second filter assembly comprising one or more reverse osmosis filters (48); (ix) a UV steriliser unit (52); and (x) an outlet (6) for purified potable water; and wherein the apparatus further comprises an electronic controller (14) for controlling and monitoring the operation of the apparatus.
Apparatus for producing potable water
The invention provides an apparatus for providing potable water, which apparatus comprises a plurality of components linked in series to provide a flow path through the apparatus, wherein the plurality of components comprises: (i) an inlet (4) for a stream of contaminated water requiring purification; (ii) a centrifugal separator (20) for separating the contaminated water stream into a partially purified water stream and a contaminant stream; (iii) a pre-filter pump (26); (iv) a pre-filter pressure sensor (30); (v) a first filter assembly (32) comprising one or more filter modules for removing particles of a predetermined size and/or removing organic contaminants from the partially purified water stream; (vi) a post-filter pressure sensor (38); (vii) a post-filter pump (40); (viii) a second filter assembly comprising one or more reverse osmosis filters (48); (ix) a UV steriliser unit (52); and (x) an outlet (6) for purified potable water; and wherein the apparatus further comprises an electronic controller (14) for controlling and monitoring the operation of the apparatus.