A tamperproof dosage form for oral administration comprising: a caplet comprising first and second ends, a middle region extending between said first and second ends, parallel and oppositely disposed top and bottom faces, and a land interposed between the top and bottom faces and extending along a perimeter of the caplet on a plane parallel to a caplet length axis; and first and second shells, each comprising an open end and a closed dome-shaped end, each fitted over at least a portion of the caplet, the portion comprising at least the first and/or second ends of the caplet and at least part of the middle region. An adhesive substance being arranged between the caplet and the shells at least over a portion of the top and/or bottom faces proximal to the first and second ends of the caplet and a corresponding portion of an inner surface of the closed dome-shaped end of the shells to fixedly join the shells to the caplet.

The present Invention relates to a pellet comprising melatonin and methods of treating insomnia.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.

The disclosure encompasses systems and methods for performing high temperature and high humidity curing of tablets using air flow delivered from a recirculating air handler to a pan coater of a tablet coating device. The recirculating air handler may be integrated into a preexisting tablet coating device so that the air flow may be delivered by the preexisting air handler or by the recirculating air handler as desired.

The invention relates to a coated famotidine particle having at least a core and a coating layer, wherein the particle core comprises famotidine, a first filler and a first binder; and wherein the coating layer is substantially free from famotidine and comprises a second filler and a second binder. The invention also relates to solid dosage forms comprising said coated famotidine particle, and the use of the coated famotidine particle for treating a subject suffering from a disease or disorder in the gastrointestinal tract.

A coating apparatus having a rotatable drum with at least one moveable separating element arranged on an end side, and granular bodies can be transferred into the drum and/or out of the drum by a movement that leads to release. A separating element can be moved from a closed position into an open position by rotation about an axis of rotation. In the closed position, a subregion lies with its underside against an inner wall of the drum or has a small gap there. In the open position, the subregion on the underside is spaced apart from the inner wall of the drum and there is an opening there through which granular bodies can pass. On the end sides of the drum there are stop elements with which a drum of at least one further module is connectable in order to form a coating apparatus and/or a closure element.

Pharmaceutical tablet properties, including surface roughness, gloss and temperature, are determined in real-time using Raman spectroscopy. A plurality of coated pharmaceutical tablets are provided having a distribution of known values of a surface property to be modeled. The Raman spectrum of each coated tablet is acquired to generate a distribution of Raman spectra. A correlative model is then developed based upon the distribution of the acquired Raman spectra relative to the distribution of the known values of the measured property. The Raman spectrum of a pharmaceutical tablet is then acquired during and/or after a coating process, and the value of the surface property of the tablet is determined using the correlative model. The steps associated with model development are carried out off-line, whereas the step or steps associated with acquiring the Raman spectra of the pharmaceutical tablet during (preferable) or after online coating process(es) are carried out on-line using a remote, fiber-coupled probe.

A particulate material coating device, comprising a vertical central column, a supply conduit for supplying the device with particulate material to be coated and a discharge conduit for discharging coated particulate material, a conveying ramp connected to the central column and a plurality of sprayers for spraying a coating agent. The supply means is arranged at the top of the device and the discharge conduit is arranged at the base of the device. The conveying ramp comprises a plurality of ramp sections arranged one above the other so as to define, between two successive sections, a drop zone for the particulate material to fall between each of the successive sections. The device aims to ensure that the particulate material is transported without areas of accumulation as well as a homogeneous coating.