A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body either in a pre-locked state or in a final-locked state. The material of the body and the cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer that covers the hard-shell capsule in the pre-locked state. The coating layer contains one or more (meth)acrylate copolymers, where the coating layer is present in an amount of about 1 to 5.8 mg/cm.sup.2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.

An apparatus for coating or encapsulating articles, having a drum with a perforated wall rotatably assembled in a wrap-around chamber and suitable for containing and stirring a batch of articles to be coated; a dispenser group with one or more nozzles for spraying a coating product; a gas inlet to direct clean drying gas against the perforated wall and a gas outlet to extract from the chamber dirty drying gas. An adjustable closure system is interposed between the drum and the gas outlet of the chamber, defining a passage for the dirty drying gas smaller than the passage by the gas outlet and further displaced or concentrated coinciding with the area of the wall of the drum that is effectively covered by the batch of articles. An automated adjustment of the locking system is envisaged, taking into account the position of the nozzles within the drum.

This disclosure generally relates to systems and methods for detecting, monitoring, and responding to abnormalities in an infant's breathing. One or more sensing devices may collect infant breathing related data, which may be filtered and converted to a frequency signal. The frequency signal may be monitored for irregularity or stoppage, and a processing module may determine whether the irregularity or stoppage is caused by an actual stoppage or irregularity in infant breathing. If infant breathing is determined to have stopped, a corrective action may be performed.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

Problem to be Solved

Provided is a method for manufacturing a pharmaceutical preparation, which safely and simply enables uniformization of contents of a small amount of a drug.

[Solution]

The method for manufacturing the pharmaceutical preparation includes: using a liquid for dispensing, the liquid containing a drug; and a first application step of applying the drug to a surface of a tablet or a capsule by a dispensing method. In addition, a pharmaceutical preparation according to the present invention includes: a base; and a drug which is applied to a surface of the base by a dispensing method, and the base is a tablet or a capsule.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

The invention is directed to a method and a device for the dosing of active substances for the preparation of medicaments. In the context of the dosing method, one or more active substances dissolved in a liquid are stored in a storage container, and, in order to permit dosing, a number of drops corresponding to the desired amount of active substance are forced actively through a nozzle onto a substrate or into a collecting vessel; the device used for this purpose comprises at least one storage container for storage of a liquid, and one or more active substances dissolved therein, and also a nozzle through which a number of drops corresponding to the desired amount of active substance are forced out onto a substrate or into a collecting vessel.

A dry powder coating apparatus for coating pharmaceutical solid dosage forms includes a housing; a drum coater; a powder coating system; a liquid spray system; a ventilation system; a heating system; a touch screen control panel; and an operation box. The drum coater may have a truncated cone on both sides, in which one side is opened and another side is closed. The drum coater is horizontally placed inside the operation box along its axis and fixed on a rotatable shaft and a motor drives the rotatable shaft and rotates the drum coater about its own axis.