The invention relates to a new method for the formulation of oily substances, and to powders and solid dosage forms obtainable thereof. The process comprises a step of spray-drying of an oil-in-water emulsion comprising an octenyl succinate starch and a maltodextrin.

A medication compounding system is described that is capable of receiving one or more medications and diluents and that includes an array of moveable transfer cartridges to access a medication container and to transfer medication. The transferred medication may be joined with a diluent to form a compounded medication. The resulting compounded medication may then be directed to a filling port where a compounded medication container may be coupled. A second medication container may align with a second transfer cartridge to transfer a second medication. Because the device may comprise one or more medications and diluents, a series of compounded medications may be created using an individual transfer cartridge for each medication.

The present disclosure relates to a process for preparing granules from an input material or a powder material. The process comprises feeding the input material for granulation in the processor using one or more powder feeders, introducing steam as a granulation activating agent in the processor, granulating the input material in presence of the steam to form granules, and optionally collecting the granules from a discharge zone of the processor, wherein feed rate of the steam into the processor is determined based on feed rate of the input material into the processor. A co-rotating twin-screw processor for preparing granules is also disclosed.

The present disclosure relates to a process for preparing granules from an input material or a powder material. The process comprises feeding the input material for granulation in the processor using one or more powder feeders, introducing steam as a granulation activating agent in the processor, granulating the input material in presence of the steam to form granules, and optionally collecting the granules from a discharge zone of the processor, wherein feed rate of the steam into the processor is determined based on feed rate of the input material into the processor. A co-rotating twin-screw processor for preparing granules is also disclosed.

Drug products in the form of modified release formulations comprising the drug substance ()-(3aR,4S,7aR)-4-Hydroxy-4m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester (AFQ056), as well as processes for making such drug products are provided. The drug products are useful in treating patients with Parkinson's disease and exhibiting L-dopa induced dyskinesia.

Drug products in the form of modified release formulations comprising the drug substance ()-(3aR,4S,7aR)-4-Hydroxy-4m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester (AFQ056), as well as processes for making such drug products are provided. The drug products are useful in treating patients with Parkinson's disease and exhibiting L-dopa induced dyskinesia.

A method of processing an active pharmaceutical ingredient, the method comprising passing a precursor composition comprising the active pharmaceutical ingredient and a solvent through a twin screw extruder wherein the twin screw extruder is heated at ambient pressure.

A method of processing an active pharmaceutical ingredient, the method comprising passing a precursor composition comprising the active pharmaceutical ingredient and a solvent through a twin screw extruder wherein the twin screw extruder is heated at ambient pressure.

Embodiments disclosed herein relate to a package comprising a plurality of chambers, each of the plurality of chambers comprising a solid unit dosage comprising an active ingredient, wherein the package is configured to provide an individualized delivery of the active ingredient in different concentrations of the active ingredient to a human or an animal. The effective amount of active ingredient is adjusted in the solid unit dosage according to the size or weight of solid unit dosage. The manufacture of the solid unit dosage comprises mixing of the active substance with pharmaceutically acceptable additives, followed by hot or cold extrusion and spheronization. The solid unit dosages can be manufactured without the use of a tablet press, lyophilization or molding. Solid unit dosages with various drug loads or many drug strengths simultaneously are produced in one batch without further processing.

A co-rotating twin screw processor for preparing dry granules including an input zone having one or more powder feeders for feeding an input material into the processor, a steam feeder configured to introduce steam as a granulation activating agent in to the processor, a granulation zone for granulating the input material in the presence of steam to form granules, a controller configured to control operation and feed rate of at least one of the powder feeder or the steam feeder such that 2.5 to 5 percent w/w of the steam with respect to the input material is available for granulation, and a discharge zone haring a non-extruding opening for collecting dry granules.