Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm.sup.3 and about 0.15 g/cm.sup.3, and/or a specific surface area (SSA) of at least 18 m.sup.2/g, 20 m.sup.2/g, 25 m.sup.2/g, 30 m.sup.2/g, 32 m.sup.2/g, 34 m.sup.2/g, or 35 m.sup.2/g. Methods for making and using such compositions are also provided.

Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm.sup.3 and about 0.15 g/cm.sup.3, and/or a specific surface area (SSA) of at least 18 m.sup.2/g, 20 m.sup.2/g, 25 m.sup.2/g, 30 m.sup.2/g, 32 m.sup.2/g, 34 m.sup.2/g, or 35 m.sup.2/g. Methods for making and using such compositions are also provided.

The present invention relates to methods for producing nanoparticle and microparticle powders of a biologically active material which have improved powder handling properties making the powders suitable for commercial use using dry milling processes as well as compositions comprising such materials, medicaments produced using said biologically active materials in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of said biologically active materials administered by way of said medicaments.

The present invention relates to methods for producing nanoparticle and microparticle powders of a biologically active material which have improved powder handling properties making the powders suitable for commercial use using dry milling processes as well as compositions comprising such materials, medicaments produced using said biologically active materials in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of said biologically active materials administered by way of said medicaments.

The present invention relates to an efficient production method of a medicament-containing particle. According to the present invention, it is possible to provide a method for producing a hollow particle composed of a shell and a hollow, wherein the shell contains a medicament and a polymer, the method including a step of adding a polymer and a solvent capable of dissolving the polymer to a powder containing a medicament while rotating a container and a stirring blade by using a rotating mixing pan, and granulating the mixture by rotating the container and the stirring blade of the rotating mixing pan, wherein the polymer used as a starting material has an average particle size of not less than 5-fold that of the medicament used as a starting material.

The present invention relates to an efficient production method of a medicament-containing particle. According to the present invention, it is possible to provide a method for producing a hollow particle composed of a shell and a hollow, wherein the shell contains a medicament and a polymer, the method including a step of adding a polymer and a solvent capable of dissolving the polymer to a powder containing a medicament while rotating a container and a stirring blade by using a rotating mixing pan, and granulating the mixture by rotating the container and the stirring blade of the rotating mixing pan, wherein the polymer used as a starting material has an average particle size of not less than 5-fold that of the medicament used as a starting material.

In one or more embodiments, the present invention provide a novel drug loaded amino acid based poly(ester urea) polymers for use in drug delivery having shape memory properties and without the shortcomings of the polymers for drug delivery known in the art, as well as related methods for their synthesis and use.

In one or more embodiments, the present invention provide a novel drug loaded amino acid based poly(ester urea) polymers for use in drug delivery having shape memory properties and without the shortcomings of the polymers for drug delivery known in the art, as well as related methods for their synthesis and use.

A process for preparing granules is disclosed. The process comprises the steps of feeding the input material for granulation in a processor using one or more powder feeders, introducing steam as a granulation activating agent in the processor, granulating the input material in presence of the steam to form granules, and collecting the granules from a discharge zone of the processor. A co-rotating twin-screw processor for preparing granules is also disclosed.

A process for preparing granules is disclosed. The process comprises the steps of feeding the input material for granulation in a processor using one or more powder feeders, introducing steam as a granulation activating agent in the processor, granulating the input material in presence of the steam to form granules, and collecting the granules from a discharge zone of the processor. A co-rotating twin-screw processor for preparing granules is also disclosed.