Various methods and apparatuses are presented for an ingestible capsule that includes a digital, ingestible sensor component—or ingestible sensor—embedded into the capsule. The ingestible sensor component may be configured to activate upon coming into contact with conductive fluid, such as a body's stomach fluid. Once activated, the ingestible sensor component may be configured to perform various tasks, such as transmitting one or more signals and obtaining biometric data about the body that ingested the capsule.

Drug products in the form of modified release formulations comprising the drug substance (-)-(3aR,45,7aR)-4-Hydroxy-4m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester (AFQ056), as well as processes for making such drug products are provided. The drug products are useful in treating patients with Parkinson's disease and exhibiting L-dopa induced dyskinesia.

Drug products in the form of modified release formulations comprising the drug substance (-)-(3aR,45,7aR)-4-Hydroxy-4m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester (AFQ056), as well as processes for making such drug products are provided. The drug products are useful in treating patients with Parkinson's disease and exhibiting L-dopa induced dyskinesia.

An internal substance supplier includes a conveying mechanism including a conveying member configured to capture and convey an internal substance, and a supply mechanism including a scraping member disposed to cross a conveyance route of the substance by the conveying member in the conveying mechanism and configured to collide with the substance conveyed by the conveying member, a gliding member including a recessed groove configured to guide the substance colliding with the scraping member and scraped from the conveying member, to be adjacent to a position vertically above a die bore in a table in a compression-molding machine, and a push transfer member including a projection configured to come into contact with the substance, push the substance to a start edge of the recessed groove in the gliding member, and move along the recessed groove to transfer the substance to an end edge of the recessed groove.

An internal substance supplier includes a conveying mechanism including a conveying member configured to capture and convey an internal substance, and a supply mechanism including a scraping member disposed to cross a conveyance route of the substance by the conveying member in the conveying mechanism and configured to collide with the substance conveyed by the conveying member, a gliding member including a recessed groove configured to guide the substance colliding with the scraping member and scraped from the conveying member, to be adjacent to a position vertically above a die bore in a table in a compression-molding machine, and a push transfer member including a projection configured to come into contact with the substance, push the substance to a start edge of the recessed groove in the gliding member, and move along the recessed groove to transfer the substance to an end edge of the recessed groove.

Embodiments provide methods and apparatus for manufacturing a microtablet from a precursor material such as a pharmaceutical powder. Various embodiments provide a method which includes compressing the powder to form a compressed mass of a selected density and repeatedly compacting the compressed mass to increase the density of the compressed mass and form a microtablet. Related methods and apparatus are provided.

Embodiments provide methods and apparatus for manufacturing a microtablet from a precursor material such as a pharmaceutical powder. Various embodiments provide a method which includes compressing the powder to form a compressed mass of a selected density and repeatedly compacting the compressed mass to increase the density of the compressed mass and form a microtablet. Related methods and apparatus are provided.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

A device for leveling the feeder platform relative to the die table of a tablet compression machine where the device has a base having top surface, a die table engaging surface and a proximate feeder platform surface. The die table surface and the proximate feeder surface are essentially flat and level or parallel with each other. The surfaces are sized such that when mounted on a tablet compression machine, the die table engaging surface is level with and parallel to the die table and the proximate feeder platform surface is approximately parallel to the feeder platform. The proximate feeder platform surface has three or more adjustable sensors attached so that the sensors are in a non-linear arrangement and are level with and parallel to the die table.