The present disclosure relates generally to bilayer tablets comprising a combination of two active pharmaceutical ingredients, and more specifically to bilayer tablets comprising acetylsalicylic acid, pseudoephedrine, and a dissolution aid. The bilayer tablets utilize a combination of granulated and non-granulated acetylsalicylic acid along with a unique distribution of sodium carbonate as a dissolution aid that provide acetylsalicylic acid and pseudoephedrine in a single dosage form having rapid dissolution and long-term storage stability (low degradation). The present disclosure also provides methods of preparing and of using the bilayer tablets.

The present disclosure relates generally to bilayer tablets comprising a combination of two active pharmaceutical ingredients, and more specifically to bilayer tablets comprising acetylsalicylic acid, pseudoephedrine, and a dissolution aid. The bilayer tablets utilize a combination of granulated and non-granulated acetylsalicylic acid along with a unique distribution of sodium carbonate as a dissolution aid that provide acetylsalicylic acid and pseudoephedrine in a single dosage form having rapid dissolution and long-term storage stability (low degradation). The present disclosure also provides methods of preparing and of using the bilayer tablets.

The invention presented is a die filling apparatus that includes a unique powder feed assembly that includes a novel plurality of vertically stacked drive gear-feed gear pairs that move filling powder through a series of sieves into a die used for compressing powder into a tablet. At least the bottom feed gear includes a plurality of logarithmic vanes or blades with an offset axis of rotation. Also presented is a method to fabricate pellets from powder using an apparatus to form a pellet.

The invention presented is a die filling apparatus that includes a unique powder feed assembly that includes a novel plurality of vertically stacked drive gear-feed gear pairs that move filling powder through a series of sieves into a die used for compressing powder into a tablet. At least the bottom feed gear includes a plurality of logarithmic vanes or blades with an offset axis of rotation. Also presented is a method to fabricate pellets from powder using an apparatus to form a pellet.

The application relates to an applicator (1) for oral administration of a swallowable object (2), in particular a solid dosage form, to a patient, wherein the applicator comprises a housing (3) having a first opening (4) and a second opening (5), the first opening of the housing being configured to be coupled with a liquid reservoir, in particular a drinking vessel, and the second opening of the housing being configured such that the patient can drink therefrom, and a holder (6) disposed within the housing and configured to accommodate the swallowable object, the holder being further configured to allow the swallowable object to be conveyed towards the second opening of the housing when liquid is flowing through the housing from the first opening to the second opening of the housing.

The application relates to an applicator (1) for oral administration of a swallowable object (2), in particular a solid dosage form, to a patient, wherein the applicator comprises a housing (3) having a first opening (4) and a second opening (5), the first opening of the housing being configured to be coupled with a liquid reservoir, in particular a drinking vessel, and the second opening of the housing being configured such that the patient can drink therefrom, and a holder (6) disposed within the housing and configured to accommodate the swallowable object, the holder being further configured to allow the swallowable object to be conveyed towards the second opening of the housing when liquid is flowing through the housing from the first opening to the second opening of the housing.

A method of producing a tablet in which an uncoated tablet is coated by a coating agent, the method including: a coating process of coating uncoated tablets with a coating agent by spray coating the coating agent onto tablets that are churned and tumbled inside a container, and drying the tablets inside the container by supplying drying air into the container and exhausting air from the container, wherein spray coating conditions, including air supply temperature, air supply rate, and spray speed, are controlled according to the weight of the coating agent with which the uncoated tablets are coated, such that the humidity of air exhausted during spray coating is within a range of from 14% RH to 30% RH.

The present invention relates to a process for the preparation of a solid pharmaceutical administration form using a 3D printing process as well. The process is a printing process that allows the production of solid pharmaceutical administration forms in a flexible manner and in conformity with the high quality standards required for the production of pharmaceuticals.

The present invention relates to a process for the preparation of a solid pharmaceutical administration form using a 3D printing process as well. The process is a printing process that allows the production of solid pharmaceutical administration forms in a flexible manner and in conformity with the high quality standards required for the production of pharmaceuticals.

Embodiments provide methods and apparatus for manufacturing a microtablet from a precursor material such as a pharmaceutical powder. Various embodiments provide a method which includes compressing the powder to form a compressed mass of a selected density and repeatedly compacting the compressed mass to increase the density of the compressed mass and form a microtablet. Related methods and apparatus are provided.