Methods of using serum glucocorticoid induced kinase 1 (SGK1) inhibitors for reducing the development of diseases related to salt and water balance, and in particular, hydrocephalus and/or hypertension, are disclosed herein. Particularly, the present disclosure is directed to the use of SGK1 inhibitors to inhibit transepithelial ion transport, such as in one embodiment, in the choroid plexus of a subject, thereby reducing cerebrospinal fluid (CSF) production or, alternatively, in another embodiment, to inhibit transepithelial sodium transport in the kidney collecting duct thereby reducing sodium reabsorption into the blood.

Methods of using serum glucocorticoid induced kinase 1 (SGK1) inhibitors for reducing the development of diseases related to salt and water balance, and in particular, hydrocephalus and/or hypertension, are disclosed herein. Particularly, the present disclosure is directed to the use of SGK1 inhibitors to inhibit transepithelial ion transport, such as in one embodiment, in the choroid plexus of a subject, thereby reducing cerebrospinal fluid (CSF) production or, alternatively, in another embodiment, to inhibit transepithelial sodium transport in the kidney collecting duct thereby reducing sodium reabsorption into the blood.

An orally ingestible contraceptive composition for a pig or rodent is provided. The exemplary composition comprises 0.005 to 1.4 wt. % free gossypol and non-free-gossypol matter. The non-free-gossypol matter comprises a bulk feed component, a pig attractant, a flavored component, or any combination thereof. An assembly may include an orally ingestible contraceptive composition for a pig or rodent and a package. A system for delivering an orally ingestible contraceptive composition to a pig or rodent may include the composition and an apparatus configured to permit pigs or rodents to eat the composition and inhibit other animals from eating the composition. A method for delivering an orally ingestible contraceptive composition to a pig or rodent includes making the composition available to the pig.

An orally ingestible contraceptive composition for a pig or rodent is provided. The exemplary composition comprises 0.005 to 1.4 wt. % free gossypol and non-free-gossypol matter. The non-free-gossypol matter comprises a bulk feed component, a pig attractant, a flavored component, or any combination thereof. An assembly may include an orally ingestible contraceptive composition for a pig or rodent and a package. A system for delivering an orally ingestible contraceptive composition to a pig or rodent may include the composition and an apparatus configured to permit pigs or rodents to eat the composition and inhibit other animals from eating the composition. A method for delivering an orally ingestible contraceptive composition to a pig or rodent includes making the composition available to the pig.

Oral compositions comprising cinnamaldehyde, and methods or improving circulation and improving circulation by administering such compositions, are described. Methods and uses are describe that include the administration of an effective amount of the oral compositions to improve circulation and increasing nerve sensitization, while also resulting in improved balance, and reduced pain, numbness, and/or tingling in the hands and feet, as well as reduced restlessness, fatigue, and tiredness of the legs.

Oral compositions comprising cinnamaldehyde, and methods or improving circulation and improving circulation by administering such compositions, are described. Methods and uses are describe that include the administration of an effective amount of the oral compositions to improve circulation and increasing nerve sensitization, while also resulting in improved balance, and reduced pain, numbness, and/or tingling in the hands and feet, as well as reduced restlessness, fatigue, and tiredness of the legs.

Oral compositions comprising cinnamaldehyde, and methods or improving circulation and improving circulation by administering such compositions, are described. Methods and uses are describe that include the administration of an effective amount of the oral compositions to improve circulation and increasing nerve sensitization, while also resulting in improved balance, and reduced pain, numbness, and/or tingling in the hands and feet, as well as reduced restlessness, fatigue, and tiredness of the legs.

The present invention relates to the combination of a retinoid and an extract of Silybum marianum (L.) Gaertn., the dermatological and dermocosmetic compositions containing such a combination, as well as their uses as a medicinal product, in particular in the treatment of acne, seborrhea, seborrhoeic dermatitis and/or rosacea.

The present invention relates to the combination of a retinoid and an extract of Silybum marianum (L.) Gaertn., the dermatological and dermocosmetic compositions containing such a combination, as well as their uses as a medicinal product, in particular in the treatment of acne, seborrhea, seborrhoeic dermatitis and/or rosacea.

The present invention relates to the combination of a retinoid and an extract of Silybum marianum (L.) Gaertn., the dermatological and dermocosmetic compositions containing such a combination, as well as their uses as a medicinal product, in particular in the treatment of acne, seborrhea, seborrhoeic dermatitis and/or rosacea.