Glycotargeting therapeutics are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent.

The present disclosure describes a method for detecting the presence of Mycobacterium tuberculosis in a bodily fluid sample. The method utilizes CRISPR effector proteins along with a guide RNA and a reporter molecule, such that when the guide RNA hybridizes with a target nucleotide fragment, the CRISPR effector protein cleaves the reporter molecule, resulting in a detectable signal.

The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.

The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.

A wireless wideband transceiver may be able to communicate with multiple frequency-hopped spread-spectrum (FHSS) devices concurrently over multiple frequencies over a short range by including a plurality of digital chains corresponding to the FHSS physical channels, individually and dynamically compensated for in-phase/quadrature imbalance in the transmit and/or receive portion. To further improve communications the transceiver may also mitigate cross interference between adjacent channel signals that are received and/or transmitted simultaneously, avoid false reception and/or transmission of co-channel signals, delay respective FHSS channels transmissions relative to other channels transmissions, speed up connection to FHSS devices and coordinate Time Division Duplexing (TDD) operation according to application dependent TX/RX binary pattern. A device that includes such a transceiver (FHSS-hotspot) may enable the concurrent usage of multiple commercially available FHSS peripheral devices without the need for additional personal host devices to be carried along with them, and in addition enable the concurrent usage of multiple commercially available FHSS personal data devices while reducing their radiation and/or latency and/or usage cost and/or power, to establish a localized multi-device multimedia session, and/or to interface with a communications network to communicate with remote parties, and/or to interface with broadcast devices to stream contents.

A wireless wideband transceiver may be able to communicate with multiple frequency-hopped spread-spectrum (FHSS) devices concurrently over multiple frequencies over a short range by including a plurality of digital chains corresponding to the FHSS physical channels, individually and dynamically compensated for in-phase/quadrature imbalance in the transmit and/or receive portion. To further improve communications the transceiver may also mitigate cross interference between adjacent channel signals that are received and/or transmitted simultaneously, avoid false reception and/or transmission of co-channel signals, delay respective FHSS channels transmissions relative to other channels transmissions, speed up connection to FHSS devices and coordinate Time Division Duplexing (TDD) operation according to application dependent TX/RX binary pattern. A device that includes such a transceiver (FHSS-hotspot) may enable the concurrent usage of multiple commercially available FHSS peripheral devices without the need for additional personal host devices to be carried along with them, and in addition enable the concurrent usage of multiple commercially available FHSS personal data devices while reducing their radiation and/or latency and/or usage cost and/or power, to establish a localized multi-device multimedia session, and/or to interface with a communications network to communicate with remote parties, and/or to interface with broadcast devices to stream contents.

Compositions and methods for the treatment of allergic disease include treating a subject in need thereof with a dosage of an allergen, wherein the allergen is administered to the subject's oral vestibular space. In a preferred embodiment, the allergen is administered at night, thereby exploiting circadian rhythms in the subject's immune response and enhancing the effectiveness of the treatment.

Compositions and methods for the treatment of allergic disease include treating a subject in need thereof with a dosage of an allergen, wherein the allergen is administered to the subject's oral vestibular space. In a preferred embodiment, the allergen is administered at night, thereby exploiting circadian rhythms in the subject's immune response and enhancing the effectiveness of the treatment.

Provided is an immunogenic composition which contains a self-assembling peptide as an adjuvant and can increase the immunogenicity of various antigens. The present invention provides an immunogenic composition including: a peptide hydrogel containing a positively or negatively charged self-assembling peptide and an aqueous medium; and an antigen, in which the self-assembling peptide is not covalently bonded to the antigen.

The present application relates to a method for managing the development and manufacturing process of a therapeutically effective formulation. Peanut proteins are characterized from peanut flour and encapsulated formulations made using the peanut flour for oral immunotherapy of peanut allergies.