The present invention concerns a complex comprising an active agent, a polymer and an iron oxide nanoparticle. The complex may also comprise an active agent. Also described are methods of releasing an active agent from the complex, for instance by irradiating the complex with radio waves. Also described are compositions and articles comprising the complex. Also described are methods of therapy and particularly methods of treatment of cancer involving the complex described herein. In addition, the invention concerns a polymer which is particularly useful in preparing the complex described herein. The polymer is capable of undergoing a phase change at a predetermined temperature, such as 39-42° C. In one embodiment, the polymer is a copolymer of N-isopropylacrylamide, acrylic acid and acrolein. In another embodiment, the polymer is a copolymer of N-isopropylacrylamide acrylamide and allyl mercaptan.

The invention pertains to a lipid-based microbubble stably binding a plurality of nucleic acids, and a method of delivering the microbubble and nucleic acids to a specific target site using ultrasound. The delivered nucleic acids create transgenic cells (i.e., for example, a transgenic tumor cell), wherein the transgenic cell expresses the proteins encoded by the delivered nucleic acids. This technology provides a significant improvement for microbubble-drug delivery platforms as known microbubble do not efficiently bind nucleic acids. The improvements described herein include but are not limited to identifying proper lipid proportionality ratios and/or cationic surfactant layers that provide an optimum mechanical index compatible with ultrasonics. Microbubble perfusion and/or nucleic acid delivery may be performed by a combination of imaging and ultrasound/microbubble targeted delivery to simultaneously perform low power two-dimensional imaging and high power microbubble destruction. Such systems are useful in therapeutics and/or diagnostics. For example, the data disclosed herein shows proof of principle in conjunction with the delivery of therapeutic siRNA molecules to slow tumor growth.

The present invention relates to a sonosensitive liposome and a method for preparing same, and the sonosensitive liposome, according to the present invention, increases the delivery efficiency of an encapsulated drug and, by being used in combination with sonication, is expected to exhibit various functions in the field of cancer treatment and drug delivery carriers through an improved drug delivery effect by means of targeting cancer cells.

Described herein are compositions featuring TRPA1 polypeptides and polynucleotides, methods for expressing such polypeptides and polynucleotides in a cell type of interest, and methods for inducing the activation of the TRPA1 polypeptide in neurons and other cell types using ultrasound.

The present invention provides acoustically activated liposome compositions for use as drug delivery vehicles, and to methods for drug release and drug delivery for therapeutic applications including Parkinson's disease and epilepsy.

The present invention concerns a thermosensitive polymeric hydrogel comprising at least one thermosensitive copolymer, one aqueous solution, and a mucoadhesive excipient, wherein said thermosensitive polymeric hydrogel further comprises at least one immunostimulatory adjuvant and/or at least one cytokine and/or at least one chemokine and/or atleast one heat shockprotein. Another object of the invention is a thermosensitive polymeric hydrogel according to the invention for use in the treatment of tumors or metastasis in a subject having a cancer, preferably a metastatic cancer.

Three-dimensional printed antibiotic scaffolds are provided as well as methods of use thereof and methods of making.

The method for eliminating microorganisms, allows to selectively neutralize pathogens. The method includes a first step which includes measuring the frequencies of pathogens within a human body which are at high population present, resulting in further illnesses or symptoms. The different sized pathogens are then applied a resonant frequency band to pre-damage/crack/weaken the hulls of the microorganisms evenly. The method further includes a second step rupturing the damaged hulls of the pathogens or oxidation of the ARN/ADN in case of a virus with a safe dose of an external oxidation product together with internal produced eNOS-expression (ROS/RNS). The external product may include chlorine dioxide in a watery solution of 0.75 ppm, vitamins, minerals and amino acids to start eNOS-expression. The method further includes a third step to deliberately terminating the activated oxidation processes. A fourth step strengthens the immune system by filling depleted levels of vitamins, minerals and amino acids.

The field of the disclosure relates generally to cancer cell destruction and, more specifically, to cancer cell destruction by photo-magnetic irradiation mediated multimodal therapy using smart nanostructures.

The present invention provides a core-shell microparticle comprising a biodegradable polymer with at least two or more surface cavities for use in the treatment of vascular disease, wherein the shell further comprises one or more drugs. The present invention further provides a core-shell microparticle which can be used for such treatments, the microparticle comprising a biodegradable polymer with at least two or more surface cavities, wherein the shell further comprises one or more drugs, wherein the one or more drugs are selected from anti-inflammatory drugs, immunosuppressants, anti-proliferative drugs, anti-coagulants and combinations thereof.