The present invention relates to pre-formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent;
wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The preformulations are suitable for generating parenteral, non-parenteral and topical depot compositions for sustained release of active agents. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.

Topical delivery systems are described. The topical delivery systems include at least one skin care active and nanocellulose in a cosmetic composition. It has been surprisingly found that the presence of nanocellulose in a cosmetic composition enhances or regulates the penetration of skin care actives. The present application further describes a cosmetic composition comprising a skin care active and nanocellulose and use thereof.

Disclosed herein are photoisomerized compositions comprising anthocyanins and methods of making an use thereof. For example, disclosed herein are methods of photoisomerizing a composition, the methods comprising: irradiating a composition comprising an anthocyanin dissolved in a solvent solution with UV light; wherein at least a portion of the anthocyanin is present as a trans isomer before the irradiation; wherein the solvent solution comprises ethanol and water in a ratio of ethanol to water (volume/volume) of 99:1 to 70:30; thereby converting at least a portion of trans isomer to a cis isomer via photoisomerization to produce a photoisomerized composition. In some examples, the photoisomerized composition has a more intense and stable blue color at pH 8 relative to the composition before irradiation.

An enzymatic process for the preparation of C16 alkyl polyglycosides and/or C18 alkyl polyglycosides by reacting C16 alkyl glycoside and/or C18 alkyl glycoside with a glycosyl donor containing monosaccharide residues to form an alkyl polyglycoside intermediate which can be fractionated to form an alkyl polyglycoside product, wherein the mole-average degree of polymerization mean DP) of the glycoside chains is greater than or equal to 3.0 units and the molar concentration of alkyl triglycoside (DP3) is greater than alkyl monoglycoside (DPI). The C16/C18 alkyl polyglycoside product is particularly useful in health care formulations, especially in combination with and/or as a solubilizer for active pharmaceutical ingredients (APIs).

A process for the preparation of C4 to C24 alkyl polyglycosides by the use of an enzyme to react C4 to C24 alkyl glycoside with a glycosyl donor containing monosaccharide residues, wherein the C4 to C24 alkyl polyglycosides have a mole-average degree of polymerization (mean DP) of the glycoside chains of greater than 1.5 units. The C4 to C24 alkyl polyglycosides are particularly useful in personal care formulations.

Milk fat globule membrane (MFGM) phospholipid compositions, methods of preparing and using the MFGM phospholipid compositions, liposomes comprising the MFGM phospholipid compositions, and methods of preparing and using the liposomes comprising the MFGM phospholipid compositions. In various examples, a MFGM phospholipid composition is formed by sequential supercritical carbon dioxide (SC—CO.sub.2) extraction of a milk product and extraction of the remaining milk product with a polar compound-modified SC—CO.sub.2 extraction, where the extract is the MFGM. In various examples, the MFGM is used to prepare liposomes. In various examples, the liposomes are prepared by expansion of a supercritical solution comprising the MFGM composition. In various examples, the liposomes are used to administer a cargo, such as, for example, hydrophilic compound(s), hydrophobic compound(s), amphiphilic compound(s), or the like, any one or all of which may be therapeutic agent(s), nutrient(s), bioagent(s), or the like, or any combination thereof to a subject.

The present invention relates to profragrance compounds and their preparation. Also disclosed are delivery systems and consumer products containing the profragrance compounds.

Evaporation of water from an aqueous dispersion of a solid peroxide such as benzoyl peroxide is retarded by the incorporation of carboxylic acid salt. The carboxylic acid salt renders the aqueous dispersion less susceptible to explosive decomposition when exposed to external triggering events such as impact, heat, friction or contamination, yet does not interfere with the ability to achieve and maintain a stable, small particle size dispersion having desirable viscosity and flow properties.

The present invention provides formulations comprising a suspension of nanocellulose (NC) elements and a drying/dispersal additive selected from the group consisting of temperature-responsive polymers, small molecule additives in volatile systems, and blocking agents and methods of preparing such formulations, and further provides NC-containing materials, composite materials and useful articles of manufacture made therefrom.

The present invention relates to ophthalmic and non-ophthalmic systems with blue light filtering and Yellowness Index ranges. UV and IR filtering are also included. Industrial applications are also outlined in the invention.