An oral care antimicrobial composition comprises about 0.1 to about 99.9 wt. % of at least one compound having the structure of

##STR00001##

Also disclosed is a process for preparing the composition and methods of use thereof.

The present invention relates to the fields of medicine, cell biology, molecular biology and genetics. In particular, the present invention provides methods to isolate and purify microvesicles from cell culture supernatants and biological fluids. The present invention also provides pharmaceutical compositions of microvesicles to promote or enhance wound healing, stimulate tissue regeneration, remodel scarred tissue, modulate immune reactions, alter neoplastic cell growth and/or mobility, or alter normal cell growth and/or mobility. The present invention also provides compositions of microvesicles to be used as diagnostic reagents, and methods to prepare the compositions of microvesicles.

Provided is at least one peptide of formula (I) and its use, where formula (I) is as follows: X-(Xaa.sub.1).sub.n-Pro*-(Xaa.sub.2).sub.m-Y (I). In formula (I), n=0 and m=1. At the N terminal end of the peptide, X is selected from H, —CO—R.sub.1 and —SO.sub.2—R.sub.1. At the C terminal end of the peptide, Y is selected from OH, OR.sub.1, NH.sub.2, NHR.sub.1 or NR.sub.1R.sub.2, R.sub.1 and R.sub.2 being independently selected from an alkyle, aryle, aralkyle, alkylaryl, alkoxy and aryloxy group, that can be linear, branched, cyclic, poly-cyclic, non-saturated, hydroxylated, carbonylated, phosphorylated and/or sulphured, with the possibility to have in said group skeleton a O, S and/or N heteroatom. Pro* corresponds to a Proline, an analogue or derivative thereof.

Novel isohexide esters and isohexide compositions are prepared and used in improving skin health and condition.

The present application provides an antimicrobial composition comprising: (a) about 0.01 to about 99.9 wt. % of at least one compound having a structure of formula (I) or formula (II):

##STR00001##

wherein R.sub.1 is hydrogen, alkyl, alkoxy or hydroxyl; R.sub.2 is hydrogen, alkyl or alkoxy; and (b) about 0.1 to about 95% wt. % of one or more antimicrobial compounds not being compounds of formula (I) and formula (II). Also disclosed is a process for preparing the compositions and method of use thereof.

N-Acyl sarcosines of Formula I, wherein, R═C.sub.7 alkyl and C.sub.10 alkenyl group with terminal double bond, are described as new antimicrobial preservatives for home and personal care products. ##STR00001## Lipidated sarcosines of this patent application preserve creams, lotions, emulsions, solutions or suspensions types of formulations of personal care industry. These are used in: leave-on ̆ (cold cream, sunscreen) as well as: rinse-off ̆ (facewash, body wash, shampoo) formulations either alone or in combination with other antimicrobials.

Cosmetic use of at least one salicylic acid derivative of following formula (I) in which L represents a linear or branched hydrocarbon radical comprising from 1 to 12 carbon atoms and having or not having one or more ethylenic unsaturations, and X represents a radical chosen from —OH and —CO.sub.2H, and also its cosmetically acceptable salts, its solvates, such as its hydrates, and its isomers, in a composition comprising a physiologically acceptable medium, as cosmetic agent intended to promote the desquamation of the skin and/or to stimulate epidermal renewal. ##STR00001##

The present invention provides a pharmaceutical composition having an excellent anti-inflammatory effect, thereby enabling effective prevention or treatment of inflammatory diseases such as reperfusion injury, periodontitis, arthritis, pressure sore inflammation, wound inflammation or dermatitis, and provides an anti-inflammatory cosmetic composition to be used as a raw material of cosmetic products that can be used for various inflammatory skin diseases.

The invention is a cosmetic or dermatological preparation and the use thereof, said preparation comprising a combination of a) glycoprotein 1, b) glycoprotein 2, ginseng extract and d) equisetum extract, to protect the skin against extrinsic skin aging.

The present disclosure relates to the technical field of sanitary cleaning products, and more specifically to a silver ion bacteriostatic hand sanitizer and preparation method and application thereof. The silver ion bacteriostatic hand sanitizer is provided, including: 0.01˜0.03 parts by weight of silver, 0.02˜0.08 parts by weight of silver sulfate, 1˜5 parts by weight of humectant, 10˜18 parts by weight of skin conditioning agent, 0.3˜0.8 parts by weight of preservative, 0.1˜0.5 parts by weight of sodium dodecyl benzene sulfonate, 0.8˜1.8 parts by weight of ethylhexylglycerol, 1˜5 parts by weight of propylene glycol, 3˜6 parts by weight of NONOXYNOL-14, 1˜6 parts by weight of PEG-50 castor oil, 0.01˜0.05 parts by weight of flavor and 80˜120 parts by weight of deionized water. The silver ion bacteriostatic hand sanitizer has the advantages of high-efficiency bacteriostasis, sterilization and itching relief, mild performance and no stimulation, and keeps the hands moisturized.