Compositions that are suitable for use as a disinfectant are disclosed. Methods of making and using compositions that are suitable for use as a disinfectant are also disclosed.

A composition comprising a wound-closure material physically or chemically associated with an agent that reduces scarring and improves the integrity of skin and underlying tissue in a mammalian subject. Methods for reducing or eliminating scarring or improving mammalian skin integrity comprise closing a wound with a composition, such as a suture material associated with a PHD inhibitor molecule, e.g., 1,4-DPCA.

In various embodiments, a tissue thickness compensator can comprise one or more capsules and/or pockets comprising at least one medicament therein. In at least one embodiment, staples can be fired through the tissue thickness compensator to rupture the capsules. In certain embodiments, a firing member, or knife, can be advanced through the tissue thickness compensator to rupture the capsules.

A high-strength hyaluronate fiber, suitable for use in a surgical suture, a lifting thread, a tissue-engineering scaffold, etc., and a manufacturing method thereof are proposed. The method includes (a) controlling a water content of a hyaluronate having a weight average molecular weight of 100-3,000 kDa to 50-95 wt % to prepare a hyaluronate paste, (b) melting the hyaluronate paste having a controlled water content at a temperature ranging from room temperature to 100° C., and then extruding the hyaluronate paste through a nozzle, and (c) drying the extruded spinning fluid to form a fiber. The hyaluronate fiber has the water content of 5-25 wt %, the tensile strength of 3 to 15 kg/mm.sup.2, and a smooth surface with small cracks, so that the hyaluronate fiber can be used for a surgical suture, a lifting thread, a filler for cosmetic surgery, a tissue-engineering scaffold, etc.

A composition of Poly(e-caprolactone)—PLC—and Graphene Oxide (GO) for use in killing bacteria that cause infections in patients implanted with medical devices, for example Staphylococcus epidermidis and Escherichia coli. Also disclosed is a method for constructing PLC/GO fibers and fibrous scaffolds by additive manufacturing and wet spinning, employing the composition and for example 3D printing. The method and compositions can be developed to produce a fibrous scaffold in which fiber diameter and PLC/GO concentrations are such that GO sheets are incorporated but at the same time exposed at the polymer surface, coffering bactericidal properties to the material, while keeping biocompatibility. Also disclosed is a fibrous PLC/GO bactericidal scaffold and the implanted medical devices having such scaffold. The composition, method, scaffold and medical devices may be used to achieve PLC/GO scaffolds and medical devices with bactericidal properties that have reduced risk of implant-associated infections.

Disclosed are devices and methods for improving healing of an enthesis. An effective amount of a composition comprising one or more sex steroids and/or sex steroid equivalents is locally administered at the site of a repaired enthesis. The composition causes upregulation of one or more chondrogenic, angiogenic, and/or tendon modulation genes, resulting in improved healing of the enthesis. The improved enthesis healing occurs even where the subject has normal levels of sex hormones.

A composition comprising a plurality of electrospun fiber fragments comprising at least one polymer, a plurality of electrospun fiber fragment clusters comprising at least one polymer, and, optionally, a carrier medium, is disclosed. Also disclosed is a kit comprising a first component of a plurality of electrospun fiber fragments, and a second component of a carrier medium. Also disclosed is a composition comprising a plurality of micronized electrospun fiber fragments, a carrier medium, and, optionally, a plurality of cells. Also disclosed is a biocompatible textile comprising a plurality of micronized electrospun fiber fragments. Also disclosed is a biocompatible suture comprising at least one electrospun fiber. Also disclosed is a method for making a biocompatible suture, comprising electrospinning a polymer solution onto a receiving surface, forming one or more non-overlapping nanofiber threads, removing the nanofiber threads from the receiving surface, and cutting the nanofiber threads into one or more biocompatible sutures.

A topical copper ion treatment in basic form comprises a copper ion-containing solution composed of a biocompatible solution containing copper ions obtained by leaching of the copper ions from copper metal into the solution. The copper ion-containing solution can be combined with various carriers to form various forms of the copper ion treatment including creams, gels, lotions, foams, pastes, tampons, solutions, suppositories, body wipes, wound dressings, skin patches, and suture material. A method of making the copper ion-containing solution involves placing solid copper metal in a quantity of a biocompatible solution and maintaining the solution at a specified temperature for a predetermined period of time during which copper ions leach from the copper metal into the solution, and thereafter separating the solution from the solid copper metal.

Disclosed are compositions comprising Rhamnus prinoides (GESHO) extract or fragments thereof and methods of using Gesho extract for the inhibition of biofilm formation.

The present disclosure provides a coating apparatus and method for applying a coating of a therapeutic agent, comprising an openable and sealable device compartment, a therapeutic agent positioned in communication with the device compartment, a thermal source for vaporizing the therapeutic agent, and a vacuum source in fluid communication with the device compartment.