A system related to the reparation of damaged veins along with the suspension of venous stasis progression by minimizing the leak reflux flow and the protection of the valve functions of the vena saphena magna, parva, perforator veins by means of exovascular or external filling agent injection in the treatment of venous stasis (which is also called varicose vein or varicose treatment).

The present invention relates to electrochemically initiated bioadhesive compositions comprising biocompatible polymers containing derivatives of diazonium, arylsulfonium, or diaryliodonium in general, and to their use in tissue fixation, in particular.

The present invention relates to electrochemically initiated bioadhesive compositions comprising biocompatible polymers containing derivatives of diazonium, arylsulfonium, or diaryliodonium in general, and to their use in tissue fixation, in particular.

The present disclosure relates to a biocompatible composition comprising a solution of low molecular weight polymer and high molecular weight polymer. The present disclosure also relates to biocompatible compositions comprising poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG), and additionally including a suspension of silica particles and/or a therapeutic agent. The present disclosure is also directed to biocompatible polymer fiber constructs formed from the disclosed compositions, methods of fabrication thereof, and uses of such constructs and compositions.

Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

A condensation curable gel composition is the disclosed. The composition comprises: (i) at least one condensation curable silyl terminated polymer having at least one hydrolysable and/or hydroxyl functional group(s) per molecule; (ii) a cross-linker selected from the group of a silicone, an organic polymer, a monosilane or a disilane molecule which contains at least two hydrolysable groups per molecule; and (iii) a condensation catalyst selected from the group of titanates, zirconates or tin (II). The molar ratio of hydroxyl and/or hydrolysable group(s) in polymer (i) to hydrolysable groups from component (ii) is between 0.5:1 and 1:1 using a monosilane cross-linker or 0.75:1 to 3:1 using disilanes. The titanates and zirconates comprise M-OR functions where M is titanium or zirconium and R is an aliphatic hydrocarbon group. The molar ratio of M-OR or tin (II) functions to the hydroxyl and/or hydrolysable groups in polymer (i) is comprised between 0.01:1 and 0.5:1.

The present invention relates to a dispensing system (1) having at least two chambers (2,3) for a tissue adhesive system comprising at least two components, wherein first chamber (2) is designed as a hollow cylinder (H), which has a closed design on an end face (2a) and an open design on its opposite end face (2b) and second chamber (3) in a solid cylinder (V) is designed as an annular gap (4) and annular gap (4) extends from an end face (3a) facing hollow cylinder (H) to a mixing chamber (5) arranged on opposite end (3b) of solid cylinder (V) and hollow cylinder (H) is arranged on the side of its open end face (2b) in annular gap (4) of solid cylinder (V) so it can move in longitudinal direction (L), wherein at least one feed duct (6) is designed in solid cylinder (V), which extends on the inside of annular gap (4) from end face (3a) of solid cylinder (V) facing hollow cylinder (H) to mixing chamber (5), wherein a mixing tube (7) is provisioned in mixing chamber (5), which projects laterally from solid cylinder (V) and is arranged so it can move essentially transversely to the longitudinal expansion of solid cylinder (V) and closes the inside of mixing tube (7) off from feed duct (6) and annular gap (4) in a first position and unblocks it in a second position. The invention also relates to a kit consisting of a dispensing system, which is filled with tissue adhesive system comprising at least two components as well as a method for closing a wound using said kit.

The invention relates to a dispenser of a sealant for hemostasis comprising a container configured to receive a fibrinogen solution and an activation compartment being situated downstream of the container and comprising a functionalized support to which a coagulation factor, preferably thrombin, is immobilized, such that upon dispensing the fibrinogen solution it passes through the activation compartment, thereby generating and dispensing polymerizing fibrin as a sealant. The invention further relates to a support, exchangeable tip and a kit for the dispenser as well as to methods and uses of the dispenser or components thereof for dispensing a sealant to a desired site.

Provided is a thrombin-carrying hemostatic sheet that is suitable for hemostasis during surgery, in particular, for hemostasis during spine surgery, that is convenient without preparation before use, and that is bioabsorbable and can be embedded in the body as it is. The hemostatic sheet is composed of a gelatin sponge carrying an effective amount of thrombin, wherein (A) the density is 30 to 55 mg/cm.sup.3, and (B) the shape maintaining angle in wet conditions is 55 to 120°.

The invention primarily relates to fastening and stabilizing tissues, implants, and/or bondable materials, such as the fastening of a tissue and/or implant to a bondable material, the fastening of an implant to tissue, and/or the fastening of an implant to another implant. This may involve using an energy source to bond and/or mechanically to stabilize a tissue, an implant, a bondable material, and/or other biocompatible material. The invention may also relate to the use of an energy source to remove and/or install an implant and/or bondable material or to facilitate solidification and/or polymerization of bondable material.