A cardiovascular fibrous implant for rebuilding elastin and the use of such an implant, wherein the implant is comprised of fibers forming a network, and wherein the fibers comprised in said network have a fiber diameter of 150 μm or less.

Methods of manufacturing and implanting corneal inlays, such as small diameter corneal inlays, are provided. The methods include manufacturing an implant body to have a meniscus shape with a small diameter and an index of refraction, and implanting the implant body in a corneal bed of a cornea. The inlays cause a change in an anterior surface of the cornea after implantation due to the implant body.

Methods of manufacturing and implanting corneal inlays, such as small diameter corneal inlays, are provided. The methods include manufacturing an implant body to have a meniscus shape with a small diameter and an index of refraction, and implanting the implant body in a corneal bed of a cornea. The inlays cause a change in an anterior surface of the cornea after implantation due to the implant body.

The invention relates to methods for treatment of bone fractures and defects, in particular to method that accelerate fracture healing, and to compositions, injectable in situ depot forming formulations and patches comprising at least one biodegradable polymer, an androgen receptor agonist and a bisphosphonate or pharmaceutically acceptable salt thereof for use in such methods.

The invention relates to methods for treatment of bone fractures and defects, in particular to method that accelerate fracture healing, and to compositions, injectable in situ depot forming formulations and patches comprising at least one biodegradable polymer, an androgen receptor agonist and a bisphosphonate or pharmaceutically acceptable salt thereof for use in such methods.

A biocompatible structure includes a scaffold obtained from a 3D structure. The 3D structure includes base layered structures, each of which includes at least a first layer and a second layer surrounded by the first layer. The first layer includes at least one of first, second and third media. The second layer includes at least another of the first, second and third media. The first medium comprises bone particles. The second medium comprises a polymer dissolvable in a first solvent. The third medium comprises solid particulates dissolvable in a second solvent different than the first solvent. The 3D structure is treated with the second solvent to dissolve the solid particulates so as to form pores at positions of the solid particulates therein, thereby resulting in the scaffold having a porosity adjustable by sizes of the solid particulates and concentration of the solid particulates in the 3D structure.

A suture thread for use in a lifting procedure according to the present invention is characterized by comprising: fixed portions composed of non-stretchable medical thread, wherein the medical thread is formed on both sides thereof and is fixed to the skin; and a variable portion that is positioned between the fixed portions and imparts structural elasticity, wherein the fixed portions and the variable portions are connected continuously, without a separate connecting structure, to form a single integrated medical thread.

Materials and methods related to elastomers are disclosed. The disclosed elastomers are useful in implants mimicking soft tissue. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

A three dimensional scaffold for generating cell or protein assemblies. This degradable scaffold can be applied to various types of cells. Also disclosed are methods of treating a condition by implanting the protein or cell assembly prepared according to the method described herein.

A three dimensional scaffold for generating cell or protein assemblies. This degradable scaffold can be applied to various types of cells. Also disclosed are methods of treating a condition by implanting the protein or cell assembly prepared according to the method described herein.