A biocompatible adhesive is disclosed. The biocompatible adhesive includes a substrate and a plurality of micro-scale elements extending from a surface of the substrate having a length selected to puncture a layer of a target tissue or target material. At least some of the micro-scale elements include at least one protrusion dimensioned to anchor the biocompatible adhesive to the target tissue or target material. A medical device assembly is also disclosed. The medical device assembly includes the biocompatible adhesive coupled to a surface of a component of the medical device assembly and positioned to attach the medical device assembly to the target tissue or target material. A method of facilitating attachment of a medical device assembly to a target tissue is also disclosed. A method of facilitating treatment of a wound is also disclosed.

A biocompatible adhesive is disclosed. The biocompatible adhesive includes a substrate and a plurality of micro-scale elements extending from a surface of the substrate having a length selected to puncture a layer of a target tissue or target material. At least some of the micro-scale elements include at least one protrusion dimensioned to anchor the biocompatible adhesive to the target tissue or target material. A medical device assembly is also disclosed. The medical device assembly includes the biocompatible adhesive coupled to a surface of a component of the medical device assembly and positioned to attach the medical device assembly to the target tissue or target material. A method of facilitating attachment of a medical device assembly to a target tissue is also disclosed. A method of facilitating treatment of a wound is also disclosed.

The invention provides a method for lubricating one or more surfaces, comprising applying gel-phase liposomes onto said one or more surfaces, wherein the temperature of said surface(s) at the time of lubrication is below the phase transition temperature T.sub.m of said liposomes. The method can be used for lubricating non-biological surfaces, and also for lubricating the surfaces of a biological tissue in a mammalian subject, e.g., for treating joint dysfunction.

The invention provides a method for lubricating one or more surfaces, comprising applying gel-phase liposomes onto said one or more surfaces, wherein the temperature of said surface(s) at the time of lubrication is below the phase transition temperature T.sub.m of said liposomes. The method can be used for lubricating non-biological surfaces, and also for lubricating the surfaces of a biological tissue in a mammalian subject, e.g., for treating joint dysfunction.

It has been established that optimizing cell seeding onto tissue engineering vascular grafts (TEVG) is associated with reduced inflammatory responses and reduced post-operative stenosis of TEVG. Cell seeding increased TEVG patency in a dose dependent manner, and TEVG patency improved when more cells were seeded, however duration of incubation time showed minimal effect on TEVG patency. Methods of engineering patient specific TEVG including optimal numbers of cells to maintain graft patency and reduce post-operative stenosis are provided. Closed, single-use customizable systems for seeding TEVG are also provided. Preferably the systems are custom-designed based on morphology of the patient specific graft, to enhance the efficacy of cell seeding.

A medical polymer material in which a phosphate group having a C—O—P chemical bond including elemental C in a main chain of a structural formula is present on a surface of a polymer material substantially free of phosphate and hydroxy groups except for ends in the structural formula.

A medical polymer material in which a phosphate group having a C—O—P chemical bond including elemental C in a main chain of a structural formula is present on a surface of a polymer material substantially free of phosphate and hydroxy groups except for ends in the structural formula.

Disclosed methods include formulating azobenzene-based polymer networks to induce a modulus change in a highly crosslinked polymer, in vivo, with no external heat requirement and using a benign light as the source of stimuli. A modulus change can be achieved via a coating on the substrate and within the bulk of the substrate via photoexposure. The azobenzene-based polymer network can be formed as a coating or in the bulk of a material from either a glassy composition comprising methyl methacrylate (MMA), poly (methyl methacrylate) (PMMA), and triethylene glycol dimethacrylate (TEGDMA) or a soft material comprising of long-chain difunctional acrylates. The disclosed technology also includes methods of biofilm disruption and removal from the surface of a substrate, and includes methods of inhibiting biofilm growth and cell attachment to a substrate.

Devices are disclosed for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance element for implantation across the mitral valve and an edge to edge device. Methods are disclose for reducing mitral valve regurgitation at low left ventricle pressure and high left ventricle pressure during the cardiac cycle. Devices are disclosed for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance element for implantation across the mitral valve with an adaptive coaptation element.

Devices are disclosed for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance element for implantation across the mitral valve and an edge to edge device. Methods are disclose for reducing mitral valve regurgitation at low left ventricle pressure and high left ventricle pressure during the cardiac cycle. Devices are disclosed for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance element for implantation across the mitral valve with an adaptive coaptation element.