The present invention relates to a zinc-containing medical device, including a zinc-containing matrix and a polylactic acid coating arranged on the zinc-containing matrix. The polylactic acid coating has a thickness of x μm; and when x and the weight-average molecular weight Mn (kDa) of polylactic acid satisfied the following formula:

[00001]$\begin{array}{c}\left(-b+\sqrt{b^2-4ac}\right)\\ \end{array}/\begin{array}{c}\\ 2a\end{array}-2\le x\le \begin{array}{c}\left(-b+\sqrt{b^2-4ac}\right)\\ \end{array}/\begin{array}{c}\\ 2a\end{array}+2,$

the corrosion rate of zinc in the matrix is relatively small, sufficient mechanical properties can be maintained within the repair period, and the biological risk is relatively low. When the polylactic acid is poly-racemic lactic acid, a=0.0336 ln(Mn)−0.1449, b=−0.472 ln(Mn)+2.1524, and c=1.1604 ln(Mn)−5.7128; and when the polylactic acid is poly-L-lactic acid, a=−0.006 ln(Mn)+0.03441, b=0.0648 ln(Mn)−0.3662, and c=−0.162 ln(Mn)+0.7847.

Embodiments of methods and apparatuses for forming the metal oxide nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure that can include both titanium oxide and nickel oxide. The nanostructure can be formed on the surface(s) of an implantable medical device, such as a stent.

The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.

This invention provides for a radially expandable stent having superior strength and reduced foreshortening properties. The stents have a mixed configuration of straight and arcuate connector segments that serve to join annular segments that make up the body of the stent. Surprisingly the described mixed configuration provides superior resistance to flip deformation while maintaining desired flexibility.

An implantable medical device includes an elongate member having a cross-sectional dimension that is less than 0.00085 inch, wherein the elongate member is made from a material comprising a platinum-tungsten alloy having a percentage of tungsten that is at least 10% by weight or alternatively the implantable medical device includes an elongate member made from a material comprising an alloy containing rhenium.

Provided is an implant magnesium alloy having corrosion resistance, mechanical strength, ductility at the same time. In one aspect of the present invention, an implant magnesium alloy contains: x at % of Zn; a total of y at % of at least one element of Ca and Sr; and the balance of Mg and inevitable impurities. x and y satisfy formulae 1 and 2:

0.15≤x≤1.5  (Formula 1)

0.5≤y≤1.5.  (Formula 2)

A method of replacing an ACL with a graft. The method provides for the drilling bone tunnels in a femur and a tibia. A replacement graft is provided having first and second ends. A biodegradable composite screw is provided. The screw is made from a biodegradable polymer and a bioceramic or a bioglass. At least one end of the graft is secured in a bone tunnel using the biodegradable composite screw.

A bioabsorbable implant including an elongated metallic element having more than 50% by weight a metal and being substantially free of rare earth elements, the elongated metallic element defining at least a portion of the bioabsorbable implant and including a wire formed into a discrete bioabsorbable expandable metal ring; at least two biostable ring elements, each biostable ring element having a biostable and radio-opaque metallic alloy, the bioabsorbable expandable metal ring being disposed adjacent to at least one of the biostable ring elements; at least one flexible longitudinal connector including a bioabsorbable polymer, the connector being disposed between at least two adjacent rings; and a coating having at least one pharmaceutically active agent disposed over at least a portion of one ring.

A method of a forming a hollow, drug-eluting nitinol stent includes shaping a composite wire into a stent pattern, wherein the composite wire includes an inner member, a nitinol intermediate member, and an outer member. After the composite wire is shaped into the stent pattern, the composite wire is heat treated to set the nitinol intermediate member in the stent pattern. After heat treatment, the composite wire is processed to remove the outer member and the inner member without adversely affecting the intermediate member. Openings may be provided through the intermediate member and the lumen of the intermediate member may be filled with a substance to be eluted through the openings.

The present invention provides a biocompatible implant comprising one or more metal(s), metal alloy(s), metal oxide(s) or a combination thereof, wherein an antioxidant compound selected from the group of flavonoids or methoxytryptophols, an ester thereof, a pharmaceutically acceptable salt thereof or a combination thereof, is/are coated to at least a part of a metal, metal alloy or metal oxide surface of said biocompatible implant. This implant is useful for replace bone tissue in vertebrate animals, and furthermore restore the normal function of said tissue, mainly due to its ability of induce osseointegration and soft tissue attachment.