The present disclosure relates to mesoporous glasses as well as uses of such glasses, for example, as hemostats

Disclosed are solid dressings for treating wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and a fibrinogen activator, wherein the haemostatic layer(s) is cast or formed from a single aqueous solution containing the fibrinogen component and the fibrinogen activator. Also disclosed are methods for treating wounded tissue using these dressings and frozen compositions useful for preparing the haemostatic layer(s) of these dressings.

The present disclosure is directed to an absorbent article including a closed cell foam matrix for delivering oxygen. The absorbent article includes a liquid permeable inner surface for facing the wearer, an outer surface for facing away from the wearer, an absorbent assembly disposed therebetween, and a closed-cell foam matrix material applied to a portion of the absorbent article. The closed cell foam matrix contains a superabsorbent material and oxygen entrapped within the superabsorbent material. To produce the closed cell foam matrix for delivering oxygen, an alkali hydroxide catalyst and oxygen precursor are both added to an aqueous superabsorbent material. The aqueous solution is applied to a nonwoven material. The nonwoven material is then heated to produce oxygen by reacting the alkali hydroxide catalyst and the oxygen precursor thereby entrapping the oxygen in the formed closed cell foam matrix.

An article. The article includes a nonwoven matrix; and bioactive glass particles enmeshed in the nonwoven matrix; wherein the article is a conformable wound dressing. A method of making the article includes flowing molten polymer through a plurality of orifices to form filaments; attenuating the filaments into fibers; directing a stream of bioactive glass particles amidst the filaments or fibers; and collecting a nonwoven matrix and bioactive glass particles enmeshed in the nonwoven matrix.

The present disclosure specifically relates to a liquid dressing for promoting wound healing. The liquid dressing comprises components of, in percentage by weight: 1% to 2% of monomeric silicic acid and 98% to 99% of distilled water. The liquid dressing also comprises aloe, vitamin C, fish oil, and curcumin. The components comprise, in percentage by weight: 1% to 2% of monomeric silicic acid, 3% to 5% of aloe, 5% to 7% of vitamin C, 1% to 3% of fish oil, 1% to 2% of curcumin, and the balance being the distilled water. The liquid dressing for promoting wound healing in the present disclosure has a great promotion effect on wound healing, particularly in accelerating healing of refractory wounds caused by hyperglycemia. Moreover, the liquid dressing for promoting wound healing in the present disclosure has a certain auxiliary effect on other refractory wounds that do not heal for a long time.

Methods for improving the antibacterial characteristics of biomedical implants and related implants manufactured according to such methods. In some implementations, a biomedical implant comprising a silicon nitride ceramic material may be subjected to a surface roughening treatment so as to increase a surface roughness of at least a portion of the biomedical implant to a roughness profile having an arithmetic average of at least about 500 nm Ra. In some implementations, a coating may be applied to a biomedical implant. Such a coating may comprise a silicon nitride ceramic material, and may be applied instead of, or in addition to, the surface roughening treatment process.

Post-operative infection in joint prostheses is a problem due to adverse consequences such as surgical debridement or implant removal. Embodiments create a coating that can be powered to release microbicidal agents to both ensure the prevention of infections, and avoid the development of antibiotic resistance. Silver ions have been well established for antimicrobial characteristics, and thus make an advantageous implant coating. Reverse electrolysis allows the ions to be released for a sustained period of time, and then collected back onto to the implant to avoid silver poisoning. A wireless reverse electrolysis system releases a sufficient amount of silver ions to break down biofilm surrounding a joint implant. By applying a modulated current waveform that has a net negative value to a conducting copper strip, the mirror current induced on the silver coating surface has a net positive flow, allowing ions to be released into surrounding tissue. Using this method, an average silver concentration of 32 ppb is created in surrounding medium after 12 hours, sufficient to eradicate bacteria directly around the silver. The ability to wirelessly induce electrolysis of silver ions to kill a significant quantity of bacteria can be used in surgical procedures to avoid post-operative infection in joint prostheses.

A part adapted for in vivo endosseous implantation made up of a material comprising a thermoplastic organic binder and a fiber charge. The fibers located in a surface layer of the part are mostly delaminated from the binder over all or part of their length. Also, a method for manufacturing such a part.

Disclosed are kits for preparing a reactive graft material and injecting the graft material into a patient. Kits may include a first syringe containing a first powdered component and a second syringe containing a second powdered component that is reactive with the first powdered component when the first and second powdered components are dispersed in a diluent solution. The kits may further include a vial sealed by a septum and containing the diluent solution. A syringe connector may be included that has a connector at each end configured to make a fluidic connection to, respectively, the first syringe and the second syringe, and also comprises a passageway adapted to allow fluid to pass between the syringes when the syringes are both fluidically connected to the syringe connector. A vial adapter comprising a connector adapted for fluidically connecting to at least one of the first syringe and the second syringe, a passageway adapted to allow fluid to pass from the vial into a syringe fluidically connected to the connector of the vial adapter, and a spike in fluidic communication with the passageway of the vial adapter may be included. The spike is adapted for piercing the septum of the vial. Certain kits also contain one or more needles for delivery of the graft material to a site within a body of a patient.

The present invention relates to an anti-aging antimicrobial wound healing polymer based hydrogel. In the study of the present invention, a wound healing gel formulation is developed by combining poloxamer polymers and boron component at adequate concentrations in a carbopol based gel. The said gel exhibits fast action on the damaged area and prevents scar formation.