Implantable matrices and methods are provided. The matrices are configured to fit at or near a target tissue site, the matrices comprise biodegradable materials and ligands bound to the matrices and are configured to bind receptors and allow influx of cells into the implantable matrices, wherein the ratio of ligands to receptors is from about 1.5 to about 0.5.

A dental implant and a method for manufacturing same which assure early stability and fixation power of an implant by suppressing early osteolysis after an implant procedure, and allowing better bone coherence of the implant surface during an osteogenic period by controlling the speed of bone remodeling.

A sheet structure formed from an extracellular matrix (ECM) composition that includes acellular ECM derived from small intestine submucosa (SIS) tissue, gentamicin and vancomycin. The sheet structure is configured to modulate inflammation of damaged biological tissue and induce cell and tissue proliferation, bioremodeling of the damaged biological tissue, and regeneration of new tissue and tissue structures with site-specific structural and functional properties, when the tissue structure is delivered to the damaged biological tissue.

Fibrous structures, for example sanitary tissue products, such as toilet tissue, containing one or more sensates, more particularly one or more TRPM8 receptor triggering agents, a sensate composition, for example surface softening composition, comprising one or more TRPM8 receptor triggering agents, and methods for making same are provided.

Described herein are surgical or wound dressings comprising a sheet of gellan gum and an antifibrotic agent.

Methods for producing dressings comprising gellan gums and biologically active agents are also described.

The invention relates to hardenable ceramic bone substitute compositions having improved setting, powders for such compositions and methods for their manufacture and use in medical treatment. More specifically the invention relates to hardenable bone substitute powder and hardenable bone substitute paste with improved setting properties, comprising calcium sulfate and heat-treated hydroxyapatite (passivated HA), which bone substitute is suitable for treatment of disorders of supportive tissue such as bone loss, bone fracture, bone trauma and osteomyelitis.

A CO.sub.2 processed sheet structure comprising ECM derived from mammalian submucosa tissue, which can be formed into a pouch configured to encase a medical device.

Vascular grafts for treating, reconstructing and replacing damaged or diseased cardiovascular vessels that are formed from decellularized extracellular matrix (ECM). The vascular grafts include structural reinforcement means, such as a strand of wound biodegradable polymeric material disposed proximate the outer surface of the graft.

The present disclosure relates to the field of endovascular treatment. More particularly, the present invention discloses a tool designed to implement an endovascular treatment capable of delivering medicine, such as amorphous hydrogel to wounds proximate to injury caused by endovascular treatment. Said hydrogel is affixed to an endovascular device.

The present disclosure relates to the field of medical treatment. More particularly, the current invention delivers medication via a coating via a hydrogel infused with pharmaceutical compounds into the bloodstream to promote the supply to the distal vascular bed beyond the stent. The present invention uses in a preferred embodiment a stent with a thin coating of biodegradable or non-biodegradable hydrogel designed to ameliorate or eliminate vasospasms or thromboses, or to treat cancer, which hydrogel may optionally be impregnated with pharmaceutical compounds. The present invention also teaches the use of thin hydrogel coatings to ameliorate treatment related difficulties.