Provided are a sliding elastic body capable of imparting excellent sliding properties and resistance to protein adsorption and, at the same time, maintaining sealing properties; and a syringe gasket, a catheter, and a tire which include the sliding elastic body. The present invention relates to a sliding elastic body including an elastic body whose surface is fully or partially laminated with a fluororesin film, the laminated elastic body being treated with a fluorinated oil.

Described herein are medical devices and medical implements with high lubricity to flesh (or biological fluid) and/or inhibited nucleation on its surface. The device has a surface comprising an impregnating liquid and a plurality of micro-scale and/or nano-scale solid features spaced sufficiently close to stably contain the impregnating liquid therebetween. The impregnating liquid fills spaces between said solid features, the surface stably contains the impregnating liquid between the solid features, and the impregnating liquid is substantially held in place between the plurality of solid features regardless of orientation of the surface.

The present disclosure provides a coating applicator operable to apply a coating of a therapeutic agent upon an object comprising an openable and sealable device compartment, a therapeutic agent positioned in communication with the device compartment, an atomizer operable to atomize the therapeutic agent, and a source of vacuum in communication with the device compartment. The coating applicator may further comprise a drier, and the drier may comprise an arrangement to operate the source of vacuum for a time sufficient to promote drying of applied therapeutic agent. Deposition of the atomized therapeutic agent may be promoted by contacting the atomized therapeutic agent while the object is in a chilled condition and by contacting the object with atomized therapeutic agent while the atomized therapeutic agent is in a heated condition. Related methods are also disclosed.

A lubricious coating for use on an implantable medical device includes a heterochelic component, a homotelechelic polymer and biocompatible initiator. Methods of forming such lubricious coatings are also provided.

The disclosure relates to a coating composition comprising a polymerizable compound of formula [1], wherein G is a residue of a hydrophobic hydroxy-functional oligomer, n is 1-10, each R1 independently is a residue of a C.sub.6-C.sub.20 aliphatic, cycloaliphatic, or aromatic hydrocarbon compound, and Z is a moiety having a polymerizable group; Formula [1] a hydrophilic polymer; a photo-initiator; optionally one or more further components, and a solvent. The polymerizable compound of formula [1] is typically present in an amount of 2.0-30 mass % based on total dry mass of the composition. Such coating composition can be made into a well-adhering single-layer hydrophilic coating on a surface of polymer substrates without providing a primer layer or chemically modifying the surface of the substrate. Upon wetting, the coating shows excellent lubricity and durability. In further aspects, the disclosure provides a method of applying a hydrophilic and optionally lubricious coating to an article; and an article like a medical device having on at least part of its surface a single-layer, hydrophilic and optionally lubricious coating, like a catheter, guidewire, or a delivery device for an implant.

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An implant comprises a substrate and a coating on a surface of the substrate, and the coating comprises silicon nitride and has a thickness of from about 1 to about 15 micrometer. A method of providing the implant comprises coating a surface of the implant substrate with the coating comprising silicon nitride and having a thickness of from about 1 to about 15 micrometer by physical vapour deposition.

A package or container for a catheter having a catheter tube with a proximal end provided with a catheter outlet and a distal opening at a distal end thereof. A gel receptacle is provided with a cavity for holding an amount of a lubricating agent, and the catheter tube extends therethrough. The gel receptacle is configured such that as the catheter is withdrawn from a stored position therein, a leading tip of the catheter is immersed in the lubricating agent, thus automatically coating the leading tip. The gel receptacle may be held within a rigid body or may be a standalone item packaged in a sterile bag solely with the catheter. A side wall of the gel receptacle is deformable so that as the catheter is withdrawn proximally the side wall is collapsed inward to displace the lubricating agent gel and coat an exterior surface of the catheter tube.

Absorbent product includes a nonwoven material arranged to be in contact with skin of a user during use of the absorbent product. The nonwoven material includes non-absorbent and/or absorbent fibres. The fibres, at least on a surface arranged to be in contact with skin of a user during use of the absorbent product, have a coarseness of from 0.1 to 10 dtex, or from 0.5 to 7 dtex. The fibres and/or the nonwoven material is coated with a lubricating coating composition suitable for use in absorbent and/or hygiene products at least on a surface arranged to be in contact with skin of a user during use of the absorbent product. By the product including the nonwoven, wet friction can be reduced between the nonwoven and the skin of the user.

Embodiments of the present disclosure provide for lubricious structures (also referred to simply as “structure”), methods of making lubricious structures, methods of using lubricious structures, and the like.

Rapid setting high strength calcium phosphate cements and methods of using the same are provided. Aspects of the cements include fine and coarse calcium phosphate particulate reactants and a cyclodextrin which, upon combination with a setting fluid, produce a flowable composition that rapidly sets into a high strength product. The flowable compositions find use in a variety of different applications, including the repair of hard tissue defects, e.g., bone defects such as fractures.