A functionally gradient material for guided periodontal hard and soft tissue regeneration includes a 3D printed scaffold layer and an electrospun fibrous membrane layer. The content of hydroxyapatite in the 3D printed scaffold layer is higher than the content of hydroxyapatite in the electrospun fibrous membrane layer. The pore size of the 3D printed scaffold layer is larger than the pore size of the electrospun fibrous membrane layer. The pore size of the 3D printed scaffold layer is 100-1000 μm, and the fiber diameter of the electrospun fibrous membrane layer is 300-5000 nm. The electrospun fibrous membrane layer is in a random distribution or an oriented arrangement or has a mesh structure. The thickness of the electrospun fibrous membrane layer is 0.08-1 mm.

Provided herein is a hierarchical superhydrophobic surface comprising an array of first geometrical features disposed on a substrate comprising a first material and a terminal level disposed on the second features, wherein the terminal level comprises a second material, the second material being different from the first material. The second material has a hydrophilicity different from the hydrophilicity of at least one of 1) the hydrophilicity of the second material and 2) hydrophilicity induced by the hierarchical structure. The present disclosure further includes methods of preparing hierarchical superhydrophobic surfaces and medical devices comprising the hierarchical superhydrophobic surfaces.

Techniques to fabricate and use a nanocomposite coating that includes one or more nanotubes such as carbon nanotubes are disclosed. In some examples, a guidewire may include the nanocomposite material. The guidewire is immune to electromagnetic interference, is thermally robust, and is capable of accommodating inactive markers and active electronics.

Provided is a cardiovascular implant based on in-situ regulation of immune response and a method for making the same, belonging to the technical field of biomedicine. The cardiovascular implant includes a cardiovascular implant body and H4000-CD25/dcas9 sustained-release nanoparticles modified on the cardiovascular implant body; the H4000-CD25/dcas9 sustained-release nanoparticles include an H4000 plasmid nanocarrier (Engreen), an anti-CD25 antibody, and a dcas9 plasmid sequence; a method for preparing the cardiovascular implant includes: constructing a cardiovascular implant body, preparing an H4000-CD25 nanotransfection vector, preparing H4000-CD25/dcas9 sustained-release nanoparticles, and conjugating the H4000-CD25/dcas9 sustained-release nanoparticles on the cardiovascular implant body. The present disclosure aims to construct a cardiovascular implant modified with the H4000-CD25/dcas9 sustained-release nanoparticles, which may induce nerve fiber ingrowth into engineered blood vessels; with the regulation ability of Treg cells on immune response, antithrombotic function of the cardiovascular implant is improved and in-situ regeneration of the cardiovascular implant is promoted.

Methods for forming micro- and/or nano-structures on the surfaces of a device and devices made thereby. The methods include exposing the surfaces of the device having an initial microstructure to an oxidizing environment at a first elevated temperature so as to form a first oxide scale on the device surfaces, exposing the first oxide scale to a reducing agent at a second elevated temperature so as to convert or partially convert the first oxide scale into a composite scale that includes a second oxide and a first metal, and exposing the composite scale to a dissolution agent that selectively dissolves part or all of the second oxide so as to yield a porous surface layer that includes the first metal.

A scaffold according to an embodiment of the present disclosure is for cartilage regeneration. The scaffold may include a plurality of linear nano-patterns aligned in one direction, and stem cells adhered to the plurality of linear nano-patterns. The scaffold may improve regeneration and maturity of the cartilage, thereby being effectively used in treatment of cartilage defects.

The invention provides a thermosensitive peptide hydrogel, which comprises water, a polyether/polyol polymer and a peptide molecule. The peptide molecule has a structure represented by the following chemical formula (1). Chemical Structure (1): ##STR00001##

An electrospinning apparatus and method for producing three-dimensional electrospun constructs is disclosed. Further, electrospinning apparatus and method 3D electrospun collagen based mineralized nanofibrous scaffold for alveolar ridge preservation prior to dental implant therapy are disclosed.

A hybrid composite and method for producing a polymer network are provided. The hybrid composite includes nanocrystalline hydroxyapatite (nHA) and polyurethane. The method for producing a polymer network includes reacting nanocrystalline hydroxyapatite (nHA) particles with lysine derived triisocyanate (LTI) to form a nHA/LTI hybrid prepolymer and reacting the prepolymer with a thioketal (TK) diol to form a nHA/poly(thioketal urethane) (PTKUR) hybrid polymer network.

Described herein is a three-dimensional platform delivery technology including a polymeric material.