Disclosed are a polyurethane condom (100) with an adhesive layer (20) and a preparation method therefor. The polyurethane condom (100) with the adhesive layer (20) comprises a first polyurethane film layer (10), the adhesive layer (20) on the first polyurethane film layer (10), and a second film layer (30) on the adhesive layer (20), wherein the adhesive layer (20) includes 0 to 100% by weight of a polar component, 0 to 100% by weight of a non-polar component, and 0 to 100% by weight of a material composed of a polar and non-polar hybrid component, and has a thickness of 0.1 to 30 μm.

An ultrasonic surgical blade includes a body having a proximal end, a distal end, and an outer surface. The distal end is movable relative to a longitudinal axis in accordance with ultrasonic vibrations applied to the proximal end. At least a portion of the outer surface of the body comprises a lubricious coating adhered thereto. The lubricious coating has a coefficient of friction that is less than the coefficient of friction of the outer surface of the body.

An embodiment includes a system comprising: a substrate of a medical device; an un-foamed polyurethane coating directly contacting the substrate and fixedly attached to the substrate; a thermoset polyurethane shape memory polymer (SMP) foam, having first and second states, which directly contacts the polyurethane coating and fixedly attaches to the polyurethane coating; wherein the polyurethane coating fixedly attaches the SMP foam to the substrate. Other embodiments are described herein.

An apparatus includes a support, including an outer surface and configured for insertion into a body of a subject. The apparatus further includes multiple atoms of a radionuclide, which radioactively decays to produce a daughter radionuclide, coupled to the outer surface, and a layer of a polymer, which covers the atoms so as to protect the atoms from being washed away, yet allows diffusion of the daughter radionuclide through the layer. Other embodiments are also described.

The present invention relates to stents made of a magnesium alloy degradable under physiological conditions having an inorganic coating comprising magnesium fluoride and having an organic coating. The stents according the invention can additionally be coated with at least one antiinflammatory, antiproliferative, antiangiogenic, antirestenotic, and/or antithrombogenic active agent.

Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems.

This application relates generally to the field of minimally invasive delivery of therapeutic agents. Specifically, the present invention provides for materials and methods directed to minimally invasive, targeted delivery of agents such as drugs, penetrants, blood barrier augmentation agents or other compounds to certain localized brain regions through the use of delivery balloon catheters.

Provided is a stent comprising: a stent skeleton; and a deposition layer containing a plurality of layers deposited on the stent skeleton; each layer of the deposition layer comprising crystalline cilostazol, at least one of the plurality of layers comprising a bioabsorbable polymer, wherein elution of not more than 5% by mass of the crystalline cilostazol occurs by 24 hours after the stent is brought into contact in vitro at 37° C. with an elution medium of a phosphate-buffered sodium chloride solution containing 0.25% by mass of sodium lauryl sulfate.

A medical balloon includes a base balloon layer and at least one cellulose fiber applied to the base balloon layer, such as by an adhesive. The cellulose fiber may include hydro-dynamically focused, cellulose nano fibers. The cellulose fiber may be a longitudinal fiber extending along the base balloon substantially parallel to the longitudinal axis, at least one hoop fiber over the at least one longitudinal fiber, or both, including possibly as a single continuous fiber. The at least one fiber may further include silk proteins, and at least one silk fiber may also be included. An outer layer, such as a polymer film or spray coating, may be applied over the at least one cellulose fiber. Related methods are also disclosed.

Disclosed is a new 3D bioprinting method of soft polymeric material such as a hydrogel or elastomer and/or cells for scaffolds or devices with structures. The method utilizes in one aspect extrusion based printing of polymer solutions, hydrogels and cells referred as direct ink writing (DIW) or BioPlotting that is modified to offer break-through advantages. The method may utilize sequential printing of a photocurable polymer solution or matrix material, and a functional hydrogel and/or cells. Printing within or inside of a viscous non-cured layer is accomplished by printing cells directly into the functional hydrogel. The viscous layer does not need to be shear thinning and thus allows use of a wide variety of bioinks never before allowed because of shear thinning and recovery requirement of commonly utilized extrusion based embedded bioprinting approach. Complex printing patterns never before allowed for bioinks are now possible utilizing this new printing method.