Subject matter of the invention are prosthetic mouldings, which have, at least area by area, at least one layer of biomimetic apatite selected from fluorapatite, hydroxylapatite or their mixtures on their surface, wherein the surface of the mouldings has micromechanical anchoring positions at least in this area to improve mechanical connection of apatite to the surface. Another subject matter of the invention are mouldings for use in dental, prosthetic treatment for tooth loss, in particular for cellular attachment of cells to prosthetic mouldings. Moreover, subject matter of the invention is the method for the production of the prosthetic mouldings.

Shapeable porous metal implants and methods for use in various procedures are disclosed. The implants can comprise a shell according to some examples. According to one example, the method can include providing a sheet of highly porous metal material having a porosity of between 55% and 90%, and wrapping the sheet of highly porous metal material around at least a first bone of the patient. Further examples can form the sheet intra-operatively to a desired shape. In an example, the porous metal sheet can be formed of tantalum or tantalum alloys.

Provided herein are biocompatible scaffolds engineered to convey growth stimulatory light to cells and augment their growth on the scaffolds both in vitro and in vivo. Also provide are methods of modifying biocompatible transparent waveguides to control delivery of light from the waveguide material.

Described herein are hydrogels attached to a base with the strength and fatigue comparable to that of cartilage on bone and methods of forming them. The methods and apparatuses described herein may achieve an attachment strength between a hydrogel and a substrate equivalent to the osteochondral junction. In some examples the hydrogel may be a triple-network hydrogel (such as BC-PVA-PAMPS) that is attached to a porous substrate (e.g., a titanium base) with the shear strength and fatigue strength equivalent to that of the osteochondral junction.

A medication impregnated bone cement (MIBC) coated intramedullary (IM) nail for fixation of a long bone fracture comprising an IM nail base and medication impregnated bone cement. The bone cement encapsulates at least a portion of the IM nail base and forms an interface between the adjacent surfaces of the IM nail base and the bone cement. The interface between the encapsulating bone cement and the encapsulated IM nail base being enhanced to increase the adhesion of the encapsulating bone cement to the encapsulated IM nail base. The increase in adhesion being sufficient to ensure that the encapsulating bone cement remains adhered to the encapsulated IM nail base when the medication impregnated bone cement coated intramedullary nail is removed from the long bone.

An osteotomy implant includes a first surface extending generally in a first plane and a second surface extending generally in a second plane, oblique to the first plane. The first surface has a perimeter having a first linear edge, a first curve edge connected to the first linear edge, a second linear edge connected to the first curved edge, and a second curved edge connected to the second liner edge.

Disclosed is a fixing bone plate, which comprises a plate body. The plate body is provided with a plate main part and a locking portion passing through the plate body. The plate main part is connected to the locking portion at the corresponding two ends of the plate body. The fixing bone plate also comprises an attachment portion. The attachment portion is provided with a bone attachment surface. The attachment portion is disposed on the other side of the locking portion. The plate body can be manufactured by using a metal laser additive manufacturing technique or a 3D metal printing technique. The fixing bone plate can be accurately positioned and stably combined with a human bone according to morphological characteristics of bones.

Compositions and methods are described for a polymer hydrogel created by a cycloaddition reaction between an azide and an alkyne that proceeds rapidly without catalyst to produce the polymer hydrogel in less than ninety seconds. The polymer hydrogel can be used in in vivo applications for the localized delivery of therapeutic agent in aqueous solutions. An example of therapeutic delivery of a protein in a mouse model is demonstrated.

The present invention relates to shaped, bone fiber-based products and methods to make the same.

A composition including, (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid, is provided. Moreover, a kit which includes: a syringe, a mineral particle covered with endothelial cells and mesenchymal cells organized in 2 or more cell layers attached to the mineral particle, and hyaluronic acid, is also provided. Last, a method for filling a gap in a bone of a subject in need thereof, including contacting the gap with a composition of: (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid is provided.