The present invention provides a scaffold for tissue regeneration and a method of manufacturing the same. The scaffold for tissue regeneration of the present invention includes grooves and ridges formed on one surface thereof, wherein the grooves or ridges have a plurality of nanopores formed thereon, thereby providing an environment suitable for attachment, differentiation, growth, and migration of cells. Therefore, the scaffold may be effectively used as a material for tissue regeneration.

Compositions and peptides for enhancing formation of cartilage in a site of a cartilage injury or defect, or joint condition, and methods of the use of the compositions and peptides in such treatments. Examples of the sites may include a knee, ankle, wrist, shoulder, elbow, patella, hip, vertebrae, femoral head, temporomandibular joint, glenoid of the scapula, jaw, and growth plate.

Described are fibrous materials comprising a plurality of fibers having a longitudinal alignment gradient and/or a longitudinal composition gradient. Also described are methods of preparing the fibrous materials thereof and methods of treating organ or tissue damage with the fibrous materials.

Described herein are hydrogels attached to a base with the strength and fatigue comparable to that of cartilage on bone and methods of forming them. The methods and apparatuses described herein may achieve an attachment strength between a hydrogel and a substrate equivalent to the osteochondral junction. In some examples the hydrogel may be a triple-network hydrogel (such as BC-PVA-PAMPS) that is attached to a porous substrate (e.g., a titanium base) with the shear strength and fatigue strength equivalent to that of the osteochondral junction.

The present invention is a multi-stage treatment that heals tissue or organ damage (e.g., linear defects, fissures, and fibrillations, as well as focal and large defects) in collagen-rich tissues and organs such as articular cartilage. The present invention includes methods 1) to prime tissues in preparation for treatment, which comprises “melting” the tissue matrix, 2) to add or fill the damaged area with a “melding” agent, comprising of endogenous or exogenous tissue matrix, with or without cells, with or without exogenous biomaterials, and with or without endogenous or exogenous enzymes, such that the melding agent enhances anchoring into the defect for the purpose of integration and/or tissue healing. The Melt-and-Meld process can also be applied in conjunction with any existing treatments of tissue or organ defects.

This invention provides coral-based scaffolds for cartilage repair, and instruments for insertion and utilization of same within a site of cartilage repair.

This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a bone graft composition comprising a growth factor such as BMP in a subject at a site of desired bone growth or enhancement in combination with a JAB1 blocker.

The present invention relates to a method of providing a graft scaffold for cartilage repair, particularly in a human patient. The method of the invention comprising the steps of providing particles and/or fibres; providing an aqueous solution of a gelling polysaccharide; providing mammalian cells; mixing said particles and/or fibres, said aqueous solution of a gelling polysaccharide and said mammalian cells to obtain a printing mix; and depositing said printing mix in a three-dimensional form. The invention further relates to graft scaffolds and grafts obtained by the method of the invention.

The present disclosure relates to modified polymers, compositions comprising the same, and methods for repairing damaged tissue in a subject, including cartilage tissue. The modified polymers, compositions comprising the same, and methods described comprise one or more tunable characteristics such that the modified polymers, compositions comprising the same, and methods form an integrated microenvironment comprising one or more of viable cells, a fibrous barrier, or a bioseal at a site of damaged tissue in a subject.

The present invention aims to provide a meniscus regeneration material having high meniscus regeneration ability. The present invention provides a meniscus regeneration material including a protein (A), wherein the protein (A) contains at least one of a polypeptide chain (Y) and a polypeptide chain (Y′); a total number of the polypeptide chain (Y) and the polypeptide chain (Y′) in the protein (A) is 1 to 100; the polypeptide chain (Y) includes 2 to 200 tandem repeats of at least one amino acid sequence (X) selected from the group consisting of an amino acid sequence VPGVG (1) set forth in SEQ ID No: 1, an amino acid sequence GVGVP (4) set forth in SEQ ID No: 4, an amino acid sequence GPP, an amino acid sequence GAP, and an amino acid sequence GAHGPAGPK (3) set forth in SEQ ID No: 3; the polypeptide chain (Y′) includes the polypeptide chain (Y) in which 5% or less of amino acid residues are replaced by at least one of a lysine residue and an arginine residue, and a total number of the lysine residue and the arginine residue is 1 to 100; the protein (A) has a total percentage of β-turns and random coils of 60 to 85% as determined by circular dichroism spectroscopy; and when the amino acid sequence (X) in which 60% or less of amino acid residues are replaced by at least one of a lysine residue and an arginine residue is denoted as an amino acid sequence (X′), a ratio of a total number of amino acid residues in the amino acid sequence (X) and the amino acid sequence (X′) in the protein (A) to the number of all amino acid residues in the protein (A) is 50 to 70%.