The present disclosure relates to tissue engineering, and more particularly to a method for treating or repairing rotator cuff or other tendon tears or damage using scaffold-free, 3-dimensional engineered tendon constructs.

A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/mL to about 1.0 mg/mL in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.

A ligament repair device and method is particularly suited to the demands of UCL repair using a scaffold device for surgical implantation across a torn ligament section. The implantable device includes an encapsulation of a therapeutic element for increasing cell proliferation and growth eluted through a controlled release storage element adapted to release the therapeutic agent over time as the cell growth progresses and the scaffold structure degrades or is absorbed in favor of the new cell growth for ligament repair. Reduced recovery time is afforded by the need for only an relatively small incision for implantation. The introduction of a physiologically relevant drug delivery scaffold encourages more rapid cell growth over passive, physical repairs to the connective tissue.

A kit and method for reconstructing an Achilles tendon may include a first anchor member, a first flexible member configured to engage the first anchor member, a second anchor member, a second flexible member configured to engage the second anchor member, a first adjustable anchor assembly including a first outer member and a first inner member configured to axially translate within a first lumen of the first outer member in response to rotation of the first inner member relative to the first outer member, a second adjustable anchor assembly include a second outer member and a second inner member configured to axially translate within a second lumen of the second outer member in response to rotation of the second inner member relative to the second outer member, and a collagen implant configured to engage a surface of the Achilles tendon.

Compositions and methods for making biocompatible articles are provided. A method includes preparing a 3D printable mixture and depositing successive layers of the mixture in a predetermined pattern to form a porous biocompatible article. The predetermined pattern has a porosity suitable for a bone or cartilage scaffold. Associated 3D printable compositions and porous articles made from the described methods are also described. The preparing a 3D printable mixture can comprise conjugating an alkyne-terminated polymer to a peptide to form a peptide-containing composite, or providing a mixture that comprises a ceramic material and a binder, and wherein the 3D printable mixture comprises from 50 wt. % to 80 wt. % of the ceramic material.

The present invention relates to a porous scaffold having excellent tissue engineering properties, and a method for manufacturing same. The scaffold of the present invention can be manufactured by a simple process, and exhibits high tensile strength and biocompatibility, as well as an excellent cell engraftment rate, and thus can be useful as a support composition for various of human transplantation, for example, as a support for artificial ligaments or abdominal wall reinforcement.

Devices, systems, and methods to improve both the reliability of soft tissue repair procedures and the speed at which the procedures are completed are provided. The devices and systems include one or more structured tissue augmentation constructs, which include constructs that are configured to increase a footprint across which suture applied force to tissue when the suture is tied down onto the tissue. The tissue augmentation constructs can be quickly and easily associated with the repair suture and can be useful in many different tissue repair procedures that are disclosed in the application. The present disclosure includes structured tissue augmentation blocks for tendon repair that have a flexible or semi-flexible skeleton integrated into the block. The skeleton can be bioabsorbable and can create both in-plane and out-of-plane curvature in the block.

The present invention relates to a method for fabrication of an extracellular matrix-induced self-assembly and to fabrication of an artificial tissue using same. The method for fabrication of an extracellular matrix-induced self-assembly comprise the steps of: (a) decellularizing and powdering a tissue-derived extracellular matrix (ECM); and (b) adding the decellularized extracellular matrix powder to cells and culturing the cells to form a cell-extracellular matrix powder self-assembly. Accordingly, the self-assembly has characteristics similar to those of extracellular matrix tissues and can be fabricated into three-dimensional artificial tissues 1 cm or greater in size, thus finding advantageous applications as a cell therapy product and an artificial tissue implant.

The invention relates to a method of producing a decellularized tissue scaffold. The invention also relates to a tissue scaffold produced by said method. In particular, porcine tissue scaffolds. The method comprises reduced levels of anionic detergent, and avoids the use of animal derived protease inhibitors to produce a tissue scaffold with favourable properties.

Pharmaceutical compositions, more specifically poloxamer copolymer-based compositions and hyaluronic acid-based compositions, containing amelogenin, are useful for promoting periodontal or orthopedic soft or hard tissue regeneration, wound closure, and skin regeneration and rejuvenation. The composition can contain a non-biodegradable thermosensitive pharmaceutically acceptable poloxamer copolymer in an amount of 18% to 30% by weight; amelogenin in an amount of 0.005% to 3% by weight; a disaccharide in an amount of 0.05% to 5% by weight; and an amino acid selected from alanine, glycine, isoleucine, leucine, proline, valine, and a mixture thereof in an amount of 0.05% to 5% by weight.