The present disclosure relates to a bone graft composition, and more particularly, to a bone graft composition including: a bone graft material; a thickener having an adhesive property; and hydroxypropyl methylcellulose as a crosslinker that forms a bond with each of the bone graft material and the thickener.

A bioabsorbable implant for non-luminal region comprising: a core structure including a magnesium alloy having a predetermined shape; a first corrosion-resistant layer containing a magnesium fluoride layer as a main component formed on the core structure via fluorination of a surface of the magnesium alloy; and a second corrosion-resistant layer containing a parylene formed on the magnesium fluoride layer.

A method of making a bone graft composition is described wherein material including decalcified bone elongated particulate bone is dried in a constraining device or under pressure to produce a solid construct having dimensions corresponding to the constraining device or space to which the material occupied under pressure.

A body made of titanium or a titanium alloy having a topography for improved blood coagulation and/or cell attachment. The body is obtainable by a process that includes the subsequent steps of: a) etching at least a portion of the surface of the body with a first etching solution including a mineral acid, and b) etching the surface etched under a) with a second etching solution different than the first etching solution, the second etching solution including hydrofluoric acid.

Embodiments of the disclosure include means of treating a variety of periodontal and dental diseases using fibroblasts, modified fibroblasts, and derivatives thereof. In one embodiment, the disclosure encompasses the utilization of fibroblasts for treatment of gum disease. In another embodiment, disclosed are means of utilizing fibroblasts and modifications thereof, for preparing gum tissue for placement of an artificial tooth. In another embodiment, fibroblasts are utilized to increase efficacy of bone grafts. In other embodiments, fibroblasts are utilized to generate artificial teeth through utilization of various scaffolding and/or 3 dimensional printing means.

A regenerative material in the connective tissues (such as bone, dentin or pulp) regeneration field. More precisely, a connective tissue regenerative material, preferably a bone, dentin or pulp regenerative material, including: a porous polymer matrix having interconnected pores; and non-hydrated calcium silicate particles; wherein: the polymer matrix is anhydrous; the non-hydrated calcium silicate particles have a d.sub.50granulometry, preferably ranging from 0.05 μm to less than the average diameter size of the pores of the matrix; and the non-hydrated calcium silicate particles being coated on the inside walls of the pores of the matrix. Also, a method for preparing the connective tissue regenerative material and uses of the regenerative materials, such as in the dental field; especially, for providing regenerative materials with improved biomechanical and osteoinductive properties (i.e. good migration, adhesion and proliferation of cells; enhanced mechanical properties; and optimal and controlled biodegradability).

A method for making a ceramic body comprised of a ceramic material having an inhibitory effect on bacterial growth is provided. A dental prosthesis may be made of a ceramic material that comprises a molybdenum-containing component on a portion of the prosthesis that contacts the gingival surface of a patient. In one method, a porous zirconia ceramic structure is shaped in the form of a dental prosthesis, and then infiltrated with a molybdenum-containing composition, before sintering to densify the ceramic structure.

The invention relates to a biocompatible, flexible, bone-adhesive sheet that may suitably be applied in the treatment of bone defects, said bone-adhesive sheet comprising: a cohesive fibrous carrier structure comprising a three-dimensional interconnected interstitial space; distributed within the interstitial space, (i) a plurality of polymer particles comprising a water-soluble calcium-binding polymer, said water-soluble calcium-binding polymer carrying at least one calcium binding group or (ii) a plurality of reactive particles comprising an electrophilically activated water-soluble polymer and a plurality of bisphosphonate particles comprising nitrogenous bisphosphonate.

The present invention generally relates to osseointegrated implants. In particular, embodiments of the present invention relate to extraosseous implants, for example, supra crestal implants, that are configured to substantially continuously cover the 3D topography of a top and a lateral surface of a bone, for example, a crestal and a lateral surface of the jaw. For example, the implants may be used on partially or completely edentulous jaws. Also, embodiments of the present invention relate to such implants made from biocompatible material of suitable porosity and elastic modulus. Specifically, embodiments of the present invention relate to improved implants suitable for implantation to bone deficient in quantity or quality, such as severely resorbed jaw bone. Further embodiments relate to a unique composite material comprising PEEK, bioglass and PMMA, and formed using triacrylate.

The invention relates to a method for manufacturing a calcified tissue substitute, the method comprising: reacting ground nacre, monocalcium phosphate, and water to produce brushite; grinding the brushite; reacting ground nacre with the ground brushite in disodium hydrogenphosphate solution. The invention also relates to a calcified tissue substitute manufactured by the method, use of the calcified tissue substitute for repairing a calcified tissue, and a delivery device for delivering the calcified tissue.