This invention provides a measure that makes it possible to prevent more effectively, in comparison with the prior art, the invasion of germs from the gap between a dental prosthesis and the gingiva when the dental prosthesis is used in an oral cavity as well as the infection and inflammation associated therewith.

There is a dental prosthesis or a component thereof, characterized in that: the dental prosthesis or the component thereof has hydroxyapatite fine particles on a surface of the dental prosthesis or the component thereof; the hydroxyapatite fine particles are sintered bodies; and the hydroxyapatite fine particles have a mean particle size of 10 to 1,000 nm.

Pharmaceutical compositions comprising amphiphilic peptides are provided. The pharmaceutical compositions are useful in treating or preventing various orthopedic and dental-related infectious and/or inflammatory conditions.

A customized resorbable three-dimensional scaffold for oral and maxillofacial bone grafting involves merging two sets of three-dimensional information obtained from a patient, the first set includes three-dimensional bone information and the second set includes three-dimensional teeth and tissue information. The merged information is used to generate a three-dimensional shape of the bone to be regenerated, a three-dimensional position of the missing tooth/teeth, and a three-dimensional model of the customized resorbable three-dimensional scaffold for oral and maxillofacial bone grafting. The three-dimensional model is used to generate the customized resorbable three-dimensional scaffold and resorbable connectors for the customized resorbable three-dimensional scaffold.

A personalized medical device intended for correction of defects, in particular in the orofacial area is multicomposite and comprises a hard tissue replacement and a soft tissue replacement. The hard tissue replacement is a hard core of biocompatible thermoplastic material and the soft tissue replacement is a biocompatible elastic substance. Preparation of personalized medical device even in the prenatal period using CT, MRI and 3D/4D electronic USG imaging and “additive manufacturing” technology.

A dried implant composition for preparing an injectable aqueous implant formulation that is extrudable through a tapering system and a gauge 18 cannula, including a mixture of nanocrystalline hydroxyapatite particles derived from natural bone having a size of 50 to 200 μm and fragments of naturally crosslinked fibrous collagen material that pass through a 0.5 mm sieve; an injectable aqueous implant formulation, wherein the injectable aqueous implant formulation is obtainable by hydration and homogeneous mixing; a process for preparing the injectable aqueous implant formulation; and a kit for preparing the injectable aqueous implant formulation.

An autologous bone graft substitute composition for inducing new bone formation, promoting bone growth and treating bone defects, a method of preparation thereof, and a method of inducing or promoting bone growth by treatment of a bone with an autologous bone graft substitute composition. The composition includes autologous blood; one or more analogs of an osteogenic bone morphogenetic protein selected from BMP-6, BMP-2, BMP-7, BMP-4, BMP-5, BMP-8, BMP-9, BMP-12, and BMP-13, and combinations thereof; and a compression resistant matrix selected from the group consisting of a bone autograft, bone allograft, hydroxyapatite, tri-calcium phosphate, and combinations thereof. The autologous blood forms a coagulum gel comprising a fibrin-meshwork reinforced with the compression resistant matrix and containing the osteogenic bone morphogenetic protein which is released over a sustained period.

Delivery and/or injection systems, preferably for medical applications. Especially, a kit of parts for providing a dental composition able to self-hardening. The kit of parts includes a first waterproof container including an anhydrous calcium silicate phase; and a second container including an aqueous phase. The kit of parts may be used in delivery and/or injection systems so that it delivers a homogenous calcium silicate-based composition having a volume ratio between the calcium silicate phase and the aqueous phase ranging from 1 to 3. Also, the hardened material obtained from the kits of parts, the delivery and/or injection system.

The present invention relates to a platelet lysate foam obtained from blood derivative (allogenic or autologous) which retains the biological properties of the platelet lysate and has optimal properties, in particular mechanical but also storage, which allow sale thereof and make handling thereof easier.

The present invention also relates to the use of a platelet lysate foam for therapeutic purposes, cell culture and cell therapy.

The present invention also relates to a process for getting a platelet lysate foam by a process of drying in a supercritical CO.sub.2 atmosphere.

Provided is an alveolar bone augmentation scaffold system. The scaffold system includes the following structures: a porous augmentation scaffold fabricated by 3D printing using composite materials for filling alveolar bone defects; a mechanical separating plate, wrapped around the porous augmentation scaffold with a biomimetic structure for restoring alveolar bone defects; the augmentation scaffold is provided with a first region close to dental pulp, a second region away from the dental pulp, and a third region surrounding the second region, wherein pore diameters of three-dimensional porous structure of the above three regions are R1, R2, and R3 respectively, and they satisfy R1≥R2>R3.

The present invention relates to the field of medical titanium alloy materials, and in particular, to a narrow-diameter high-strength implant-specific medical titanium alloy achieving immediate implant placement and a preparation method for the implant-specific medical titanium alloy. The medical titanium alloy is prepared from the following chemical components (by weight percentage), 14%-17% of Zr, 3.0%-10% of Cu, and the balance of Ti. The preparation method for the medical titanium alloy comprises: after cogging and forging and before rolling, performing heat preservation for 0.5-6 h at the temperature of 900-1200° C., and water cooling to the room temperature; and rolling at the temperature of 720-850° C., a strain rate being larger than 0.1 s-1, and a barstock obtained after rolling being used for subsequent implant processing. According to the narrow-diameter high-strength implant-specific medical titanium alloy achieving immediate implant placement provided in the present invention, immediate implant placement can be achieved without any surface treatment, and a firm combination of the implant and a bone tissue is achieved. According to the preparation method for the medical titanium alloy provided in the present invention, the implant having a narrow diameter (3.0-3.5 mm) can be prepared and is high in strength, and the purpose of firm implanting on a narrow teethridge missing a tooth is achieved.