Disclosed is an isolated peptide including the consensus amino acid sequence SEQ ID NO: 1:

TABLE-US-00001 (SEQ ID NO: 1) HGEGSFX7SDX10 SX12X13LDKLAARDFVNWLLQTK wherein X7 is any amino acid residue, X10 is any amino acid residue, X12 is any amino acid residue and X13 is any amino acid residue. Also disclosed are methods of using such peptide in the treatment of bone disorders.

A human amniotic fluid formulation has been developed for administration into a joint or associated soft tissue such as a tendon or ligament for treatment of pain, degeneration or injury. The formulation is a sterile de-cellularized human amniotic fluid (D-HAF), devoid of amniotic stem cells and elements of micronized membrane or chorion particles, which has not been heat treated or treated with ethidium bromide. The formulation is optionally diluted, or concentrated, depending on he severity of the disorder or injury. Examples demonstrate efficacy in treatment of pain, disease, disorder, degeneration or injury of a joint or associated soft.

The present patent application is directed to compositions and shaped structures implantable into mammalian bodies, the compositions and shaped structures having localized bioactive surfaces.

Compounds, pharmaceutical compositions, and a method of treating hard tissue diseases and disorders are disclosed. The compounds may be a peptide and is structured to bind integrin α.sub.vβ.sub.3 expressed by osteocytes and by selective binding to the cell surface integrin on hard tissue forming cells regulate three-dimensional bone shape, cartilage formation and repair.

The present invention provides a prosthetic device including a pad-shaped spacer (100) including expandable layers (30) having a structure that expands in response to the introduction of moisture because the expandable layers (30) are made of a hydrogel material, so that in a surgery or treatment process, water is absorbed into the expandable layers (30) and fill a space inside a muscle or joint (J) tissue in a state in which the spacer (100) is implanted inside the space inside the muscle or joint (J) tissue until a new tissue grows inside the muscle or joint (J) tissue for a predetermined period of time, and the expandable layers (30) degrade gradually at a rate corresponding to a rate at which the tissue grows, with the result that the muscle or joint (J) tissue can be used during a recovery period.

To provide a bioimplant capable of controlling a rate of an antibacterial agent and an antibiotic to be eluted from the coating film. An evanescent coating film made of a calcium phosphate-based material having crystallinity of 10% to 90% is formed at a predetermined area of the bioimplant and an antibacterial agent or an antibiotic is contained in the coating film to suppress adhesion of bacteria.

A joint spacer, in particular a knee spacer and a hip spacer is provided which is long-lasting and is sufficiently cushioned and abrasion-resistant and which can also support locally very high loads. A method for treating osteoarthritis by inserting a disk-shaped member into a joint of a patient is also disclosed.

A ligament-derived graft is provided which comprises a portion of a ligament sample recovered from a mammalian donor and which has been cut approximately in half lengthwise, where the ligament derived graft has dimensions suitable for use in a surgical procedure to repair small to mid-sized, or less load bearing joints. Small joints for which the ligament-derived grafts may be used to repair, include, interphalangeal, metacarpophalangeal joint, scapholunate joint, and other joints. In some embodiments, the dimensions of the ligament-derived graft include a length of from about 50 mm to about 150 mm, and a width of from about 3 mm to about 20 mm. In some embodiments, ligament samples used to make the ligament-derived grafts are lateral or medial collateral ligaments. Methods of using such ligament-derived grafts include attaching one or more ligaments, at their ends, to bones on opposite sides of the joint being repaired, so that the ligament(s) extend across the joint. When two grafts are used, they may extend across the joint, either on the same or opposite lateral sides of the joint.

Methods, compositions, and kits for adhering polymers and other materials to another material, and in particular to bone or bone-like structures or surfaces. A composition of matter includes a urethane dimethacrylate-methyl methacrylate copolymer with a plurality of first polymer regions based on urethane dimethacrylate and a plurality of second polymer regions based on methyl methacrylate. The method includes placing an orthopedic joint implant having an attachment surface in a joint space, applying a first non-urethane-containing precursor, a second urethane-containing precursor, and a initiator to the attachment surface; contacting the first and second precursors and the initiator with the joint surface; and copolymerizing the first and second precursors and forming an adhesive copolymer and attaching the implant to the joint.

The invention relates to a method of producing an implantable collagen-containing medical device comprising the step of coating said collagen-containing medical device with metal microparticles and/or metal nanoparticles, wherein said step of coating said collagen-containing medical device is by sonication such that the collagen-containing medical device has anti-bacterial and anti-inflammatory properties on implantation compared to the medical device not coated with metal microparticles and/or metal nanoparticles.