An implant, preferably for treating and/or reconstructing, in particular lining and/or sealing and/or relining and/or at least partially filling an acetabular defect, having at least one flat structure which contains a material that is at least partially decomposable or resorbable in vivo. The invention further relates to a surgical kit and the use of an unfinished flat structure for producing an implant.

There is provided a method for decreasing leakage of matter from an object to a surrounding, said object being coated with a coating at least partially applied on the object, said coating comprising an at least partially covering layer comprising silver, said object optionally comprising area(s) without said layer, said coating comprising metal particles applied on the layer and optionally on areas without said layer, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, niobium, neodymium and platinum and wherein the amount of the metal particles is in the interval 0.01-8 μg/cm.sup.2. Advantages include that leakage of matter such as latex allergens of metal ions can be reduced while the coating is both biocompatible and antimicrobial. Further, the blood clotting can be reduced.

Compositions including a decellularized and enzymatically solubilized amnionic membrane (AM) hydrogel, methods for making such compositions, and methods for their use are disclosed.

Antibacterial coatings and methods of making the antibacterial coatings are described herein. In particular, a method for forming an organocatalyzed polythioether coating is provided in which a first solution including a bis-silylated dithiol and a fluoroarene is prepared. A second solution including an organocatalyst is prepared. The first solution and the second solution are mixed to form a mixed solution. The mixed solution is applied to a substrate, and the substrate is cured.

A joint spacer is provided for treatment of a joint of a human subject, the joint spacer including a pouch having a wall including a dermal graft material. The joint spacer is configured to be inserted into a space of the joint, and is shaped, when the pouch is inserted into the space and filled, to provide mechanical support to the joint. Other embodiments are also described.

Described herein is a 3D-printed scaffold comprising a peptide-polymer conjugate, the peptide-polymer conjugate having the structure: X-Y-Z-Y-X, wherein X is a biologically active peptide, Y is a linker moiety, and Z is a biocompatible and biodegradable polymer.

Disclosed herein, in certain embodiments are methods of preparing a fetal support tissue product comprising: cryopulverizing or homogenizing a fetal support tissue, extracting the cryopulverized fetal support tissue in an excipient, and sterilizing the extract. Also disclosed herein are pharmaceutical compositions comprising said fetal support tissue product and methods of using said fetal support tissue product for treating wounds, spinal conditions, and arthritis.

A humeral implant configured for implantation at a distal end portion of a humerus. The humeral implant can be configured to articulate with a portion of an ulna. The humeral implant may include a body portion having a first end, a second end, and a side surface that extends between the first end and the second end, where the side surface includes a concave region that defines a first cross-sectional diameter that is a minimum cross-sectional diameter of the body portion.

Method to produce a single-piece prosthetic component (110, 210, 310, 410, 510, 610, 620, 710, 810, 910) that comprises making available a substrate (12) and making a coating layer (14) thereon.

An improved new method of making a multi-component implant comprising a solid hydrogel, a porous hydrogel, and a porous rigid base suitable for implantation into a mammal, to treat, repair or replace defects and/or injury biological tissue as well as the implant made from the improved method. The invention also includes an improved method for making devices, constructs, and materials comprising a hydrogel and a porous rigid material. The invention also includes a mold and kits for performing the methods.