An implantable tissue stabilizing structure for regenerating damaged muscle in situ by enabling mass migration of muscle precursor cells into the damaged muscle. The structure is formed by a plurality of singular monofilament thread sections, which are separated by a plurality of void spaces that define linear distances between the threads. The maximal diameter of the threads is proportional to the linear distance, such that for linear distance less than 1 millimeter the maximal threads diameter is 40 microns, for linear distance from 1 to 2 millimeters the maximal diameter is 120 microns, for linear distance from 2 to 5 millimeters the maximal diameter is 400 microns, for linear distance from 10 to 20 millimeters the maximal diameter is 2.5 millimeters, and for linear distance of 40 millimeters and greater the thread sections maximal diameter is 10 millimeters.

The present disclosure provides matrix compositions comprising bioactive glass and methods for treating a defect in tissue demonstrating volumetric tissue loss arising from injury or congenital defect.

Disclosed herein are systems for promoting healing of a wound or surgical incision at a medical device site (e.g., implanted medical device) in a subject, by administering a microporous gel to the medical implant site. Also disclosed are systems for the treatment and prevention of infection at a medical implant site in a subject, by administering a microporous gel to the medical implant site. The microporous gel may be fluidic during application and annealed or crosslinked after application. The microporous gels may contain various therapeutic agents, including antibiotics and analgesics, throughout the gel.

The invention relates to a method for preparing a polymer scaffold that comprises the steps of providing a piece of a fabric of filaments of a first biodegradable or biocompatible polymer, applying a coating of a second polymer to said arrangement of filaments, and stretching the piece along its axis of longitudinal extension, thereby obtaining an aligned microfibrillar scaffold. The invention further relates to a method for providing an artificial tissue, and to a microfibrillar scaffold of aligned filaments obtained by the method of the invention.

The present invention relates to a composite membrane (10) comprising a fibrous fabric (1) of nanofibres (11), wherein the thickness of the fabric (1) is between 10 nm and 50 m and said fabric is impregnated with a wetting liquid (A). According to the invention, the composite membrane is immersed in a second fluid (B) which is immiscible with the wetting liquid (A), forming an A/B interface between the wetting liquid (A) and the immiscible fluid (B), and the composite membrane is capable of remaining tensioned when it is compressed from its resting state until reaching dimensions corresponding to 5% of its dimensions in the resting state, and when it is stretched from its compressed state until reaching dimensions corresponding to 2000% of the length in the compressed state. The present invention also relates to a process for manufacturing such a membrane.

There are provided tissue repair laminates containing at least two biodegradable polyurethane foam layers and a polyurethane structural layer. The biodegradable polyurethane is derived from biodegradable polyols. The laminates resist shrinkage under in vivo conditions and possess desirable mechanical properties such as high tensile strength. The laminates find use in, for example, the repair of tissue or muscle wall defects.

Provided herein are inks including decellularized extracellular matrix (dECM) particles and scaffolds made from the inks. Also provided are methods of making the scaffolds and applications for the scaffolds. In an embodiment, a porous scaffold comprises dECM particles and an elastomer, wherein the scaffold is planar having a thickness of about 100 ?m or greater, the scaffold comprises irregularly shaped pores having a random orientation and distribution throughout the scaffold, and the scaffold is free of crosslinking between the molecular components of the scaffold.

An engineered vocal fold mucosa, including an engineered lamina propria layer and an engineered squamous epithelium layer, is disclosed. The engineered lamina propria is made by seeding and culturing human vocal fold fibroblasts within a polymerized collagen scaffold, and the engineered squamous epithelium is made by culturing human vocal fold epithelial cells on the scaffold surface. The resulting engineered vocal fold mucosa is not immunogenic, and is capable of exhibiting the vibratory function and acoustic output of a native vocal fold mucosa. Accordingly, the engineered vocal fold mucosa may be implanted into the larynx to treat voice impairment.

The present invention relates to a biomaterial fabrication process for the manufacture of a collagen based fabric for an aligned collagen fiber network.

A composition comprising Polyhydroxyurethanes, Glycosaminoglycans, hydrolysed glycosaminoglycans, glycosamines of glycosaminoglycans, chemically modified or not and a Protein or a peptide; said protein being collagen, elastin, keratin, fibronectin, actin, myosin, laminin, a peptide or a blend of those proteins or peptides, fibrillated, hydrolysed, chemically modified or not. This homogenous composition is obtained by the polymerisation or the covalent bounding of two preparations containing cyclic polycarbonates, polyamines, glycosaminoglycans, hydrolysed glycosaminoglycans, glycosamines, chemically modified or not and proteins or peptides or a blend of those proteins or peptides, fibrillated, hydrolysed, chemically modified or not.