Systems and methods are provided for separating blood into two or more components. A blood separation system includes a blood separation device and a fluid flow circuit configured to be mounted to the blood separation device. The blood separation device includes a centrifugal separator and a spinning membrane separator drive unit incorporated into a common case, which allows for fluid separation by two different methods. Depending on the separation procedure to be carried out, the fluid flow circuit paired with the blood separation device may include only one separation chamber configured to be mounted to the centrifugal separator or spinning membrane separator drive unit or two separation chambers, with one being mounted to the centrifugal separator and the other to the spinning membrane separator drive unit. The system may be used to separate and collect any combination of red blood cells, plasma, and platelets.

A device for aseptic delivery of biological material from a vial includes a tubular barrel, a filter assembly, and a dispersion funnel assembly. The tubular barrel includes a receiving end to accept at least a portion of the vial within the tubular barrel, and a dispensing end opposite the receiving end. The filter assembly is fluidly connected to the dispensing end of the tubular barrel. The dispersion funnel assembly is configured to connect to the vial, and to be disposed at least partially within the tubular barrel. The dispersion funnel assembly has an open configuration to disperse the biological material from the vial into the tubular barrel between the dispersion funnel assembly and the filter assembly, and a closed configuration to force the dispersed biological material through the filter assembly when the dispersion funnel assembly is moved toward the dispensing end of the tubular barrel.

A blood component separation device for separating a plurality of blood components from blood sampled from a blood donor, and collecting platelets, includes: an operation unit that calculates a predicted platelet recovery rate from a hematocrit value of the blood and a platelet concentration of the blood, and calculates a recommended processing amount of the blood recommended for collecting a target number of units of platelets on the basis of the calculated predicted platelet recovery rate, wherein the operating unit sets the predicted platelet recovery rate calculated from any the hematocrit value and any the platelet concentration to be smaller by a predetermined value a when the blood donor is female than that when the blood donor is male.

A blood treatment filter comprising a filter element, an inlet-side flexible container and an outlet-side flexible container, an inlet port, and a tubular outlet port, further comprises: an outlet-side frame sheet disposed between the filter element and the outlet-side flexible container; a first seal portion provided by sealing at least the filter element and the outlet-side frame sheet in a belt-shaped manner; and an annular second seal portion provided to surround the first seal portion, wherein on an outlet side of the filter element, a valley portion is formed at the first seal portion, the outlet port includes a protruding portion that protrudes to an inside of the container, and the protruding portion is provided with an opening at least a part of which overlaps with the first seal portion and which can communicate with a gap region formed by the valley portion.

Process and system for acellular therapy in a human subject are provided. The process and system relate to an acellular therapy using therapeutic extracellular vehicles fused to biological material obtained from the subject, via transfusion by extracorporeal systems. The process for acellular therapy is in a subject in need of such therapy.

The invention relates to a system for platelet release from a fluid comprising in particular megakaryocytic cells comprising cytoplasmic extensions.

The system allows to reproduce the pipetting process performed manually by means of a pipette, thereby permitting a continuous and automatic release of platelets.

This is performed on a large scale since the geometry of the system according to the invention allows to treat large volumes of fluid with a high flow rate (of the order of a plurality of liters per hour), thereby making it particularly suitable for use on an industrial scale.

The invention also relates to a method for platelet release from a fluid comprising in particular megakaryocytic cells comprising cytoplasmic extensions, said method being implemented by means of the abovementioned system.

A blood separation system is provided with a data entry device, a blood separator, a pump system, and a controller. The controller compares data regarding a blood source that is received by the data entry device and/or calculated values derived from the data to a target range, a maximum value, and/or a minimum value. The controller requests reentry or confirmation of at least a portion of the data when the data or calculated value is outside of the target range, less than the minimum value, and/or greater than the maximum value. The controller instead proceeds with a blood separation procedure when the data or calculated value is not outside of the target range, less than the minimum value, and/or greater than the maximum value or after determining that there have been no data entry errors.

Methods and systems for transfusing reduced-volume blood components are disclosed. Previously collected blood components are introduced into a fluid circuit associated with an apparatus that further separates the component into a reduced volume component and supernatant. The reduced-volume blood component is transfused to the patient in need of the component without the risk of circulatory overload.

Provided is a blood component sampling cassette which can be efficiently manufactured at low cost compared to a conventional cassette, a method for manufacturing the blood component sampling cassette, a blood sampling circuit set and a blood component sampling system. The blood component sampling cassette includes a cassette main body having a plurality of flow paths including an introduction line, a blood component transfer line and a retransfusion line. The cassette main body includes a first sheet and a second sheet which are formed of a soft material compatible with autoclave sterilization. The first sheet and the second sheet are overlaid in a thickness direction and bonded to each other. A plurality of flow paths is formed between the first sheet and the second sheet.

Apparatus and methods for concentrating platelet-rich plasma is described herein. One variation may generally comprise a tube having a length and defining a channel within and one or more ports located at a proximal end of the tube and in fluid communication with the channel. A plunger may slidably translatable within the channel while forming a seal against an inner surface of the channel and a float may have a pre-selected density and defining a concave interface surface, wherein the float is slidably contained within the channel such that the concave interface surface is in apposition to the one or more ports.