A method is provided that includes intranasally dispensing nasal wash fluid into a nasal cavity of a subject such that the nasal wash fluid washes biological material into an oropharynx of the subject from (a) the nasal cavity, (b) a nasopharynx of the subject, or (c) the nasal cavity and the nasopharynx. The method further includes, thereafter, collecting a specimen sample that passed out of an anterior opening of an oral cavity of the subject and contains at least a portion of the biological material washed into the oropharynx by the nasal wash fluid. Thereafter, information is derived from extracellular vesicles present in the specimen sample. Other embodiments are also described.

A device for ocular surgery includes a surgical handpiece including a power cord and an aspiration needle for removing ocular material from an eye, and co-extruded tubing. The tubing includes an aspiration tube for receiving the ocular material removed from the eye by the surgical handpiece, an irrigation tube integrally formed with the aspiration tube for supplying irrigation fluid to the surgical handpiece, and a ridge defined along at least a majority of a length of the co-extruded tubing, the ridge defining a groove for receiving the power cord of the surgical handpiece.

A tissue resecting instrument includes a housing, a shaft rotatable relative to the housing and defining a proximal end portion disposed within the housing and a distal end portion distally-spaced from the housing, a cutting member operably associated with the distal end portion of the shaft, a turbine disposed within the housing and operably associated with the proximal end portion of the shaft, and a fluid outflow tube operably associated with the housing. The fluid outflow tube is adapted to connect to a suction source to enable the suctioning of fluid and resected tissue proximally through a lumen of the shaft, an interior of the housing, and into the fluid outflow tube. The turbine is configured such that proximal fluid flow across the plurality of fins of the turbine urges the turbine to rotate, thereby rotating the shaft relative to the housing to enable tissue resection with the cutting member.

A peristaltic pump includes a first motor shaft, a second motor shaft, a first pump head, a second pump head, and a motor. The first pump head is operably coupled to the first motor shaft such that the first pump head is rotated in response to rotation of the first motor shaft. The second pump head is operably coupled to the second motor shaft such that the second pump head is rotated in response to rotation of the second motor shaft. The motor is configured to rotate the first and second motor shafts. The pump head has a first mode in which the first pump head is rotated and the second pump head is idle and a second mode in which the first pump head is idle and the second pump head is rotated.

A surgical cassette for an ophthalmic surgical system comprises an irrigation system and an aspiration system. The irrigation system is in fluid communication with a handpiece and carries fluid toward a surgical site. The aspiration system is in fluid communication with the handpiece via an aspiration conduit, and carries fluid away from the surgical site. The aspiration system comprises a chamber that expands to store fluid, and collapses to move the fluid to meet a volume demand in the aspiration conduit to mitigate a post-occlusion break surge.

Ablation systems and methods of the present disclosure include a catheter including one or more image sensors. The one or more image sensors can facilitate, for example, positioning an ablation electrode at a treatment site of an anatomic structure and, additionally or alternatively, can facilitate controlling delivery of therapeutic energy to a treatment site of an anatomic structure.

A nozzle (10) for a container for the intranasal administration of a liquid formulation comprises a nozzle body (12) with an upper end (18) and a lower end (16), a channel (40) traversing the nozzle body (12) and ending with an orifice (17) in the upper end (18), and a nozzle cover (14) covering an area of the outer surface of the nozzle body (12) which is designed to be introduced into a user's nostril, wherein the nozzle body (12) is made out of a first material and the nozzle cover (14) is made out of a second material, said first material being a rigid plastic material, and said second material being an elastic plastic material, and wherein the nozzle cover (14) is not in contact with the orifice (17). A packaging for a liquid formulation for intranasal administration comprises a container and such nozzle (10). A product comprises such a packaging and a liquid formulation in said packaging.

A peristaltic pump comprises a rotor with rollers and first and second tracks mounted on opposites sides of the rotor. Each track is moveable between a first position adjacent the rotor and a second position spaced from the rotor. The tracks may be linked and moveable together so that as one track moves towards the rotor, the other moves away from the rotor and vice versa. In this way, a single pump can be used to provide two different modes of operation, e.g. pumping liquid when one track is adjacent the rotor and applying suction when the other track is adjacent the rotor.

The presently disclosed embodiments relate to insufflation and irrigation conduits for vessel harvesting systems and methods of their use. In particular, the present disclosure relates to a system having a combined cabling for providing gases, liquids, and/or electrical power to an attached medical device and method of use.

The presently disclosed embodiments relate to insufflation and irrigation conduits for vessel harvesting systems and methods of their use. In particular, the present disclosure relates to a system having a combined cabling for providing gases, liquids, and/or electrical power to an attached medical device and method of use.