A multi-use needle assembly (200) for an injection device (50), wherein the injection device (50) comprises: a housing (52) and a cartridge (54) for storing a liquid drug for multiple injections, the multi-use needle assembly comprises: a support structure (201), needle cannula (210), a movable shield assembly comprising a movable shield (220) and an actuation member (222) fixed to the shield (220), and a cleaning assembly (230) adapted to change configuration by deformation. The shield (220) is adapted to be in a locked distal position, an unlocked distal position and an unlocked proximal position, and the cleaning assembly (230) is adapted to be configured in (i) an open configuration, wherein a gap is provided between an outer surface of the cannula (210) and the cleaning assembly (230) to allow adjustment of the relative axial position between the cleaning assembly and the cannula, (ii) a closed configuration, wherein the cleaning assembly (230) is configured to provide contact with the outer surface of the cannula to enable cleaning of the cannula. The actuation member (222) is adapted to deform and thereby operate the cleaning assembly (230) between the open and the closed configuration, in response to turning the shield between the unlocked and the locked configuration. The needle assembly (200) is adapted to enable cleaning of the cannula (210), when the shield (220) is in the locked distal position, and to allow exposure of the cannula (210), when the shield (220) is in the unlocked distal position.

The invention relates to an injection device for injecting doses of a liquid drug, which comprises an immobilization mechanism such that the further use of the injection device is immobilized in response to the needle cannula (20) being exposed to an axial force above a predetermined value: the immobilization mechanism comprises a flexible arm (50) which apply a radial force onto the needle cannula at least during injection.

Impedance is detected between electrodes coupled to an indwelling medical device to monitor bacteria growth and/or formation of a bacterial biofilm in an in vivo environment. When an antimicrobial agent is present in the in vivo environment, the same voltage that enables impedance detection also generates a bioelectric effect, which decreases a size of the bacterial biofilm or inhibits growth of the bacterial biofilm. In some embodiments, the impedance detected between the electrodes can also be used as a feedback mechanism. When detection indicates that a bacterial biofilm has formed, the system can take remedial measures, such as introducing an antimicrobial agent to the in vivo environment and/or delivering a voltage higher than detecting voltage to deliver a greater bioelectric effect. In some embodiments, the electrodes can be formed on a flexible substrate that is mounted on and conforms to a non-flat surface of the indwelling medical device.

The invention relates to a medical assembly, preferably a sterilized one, comprising a medical article (5) and a package containing said article, said package comprising a hollow support element (2) inside which said article (5) is free, a first protective element (3), called a stopper, which can be coupled to the support element (2) of said article, such that the support element (2) has a grip part (20) that protrudes from said stopper (3), and a second hollow protective element (4), called a cover. Said cover can be coupled to the stopper (3) in such a way as to delimit, in cooperation with said stopper (3), a chamber (8) inside which there extends said grip part (20) of the support element, and, in the state when the cover is coupled to the stopper, a part of the stopper (3) protrudes from the cover (4).

The present invention relates to a pre-filled disposable injection device and a needle cannula in combination. The prefilled disposable injection device (1) is made from a housing (2) containing a non-exchangeable cartridge (10) for storing a liquid drug sufficient for a number of injections. The proximal end of the pre-filled injection device (1) carries the dose setting button (3) and the distal end carries the needle cannula (20) having a lumen (21) through which the settable dose is expelled. The distal end (23) of the needle cannula (20) is covered by a telescopic needle covering shield (30) which shield (30) can operate between a first position covering the tip (24) of the needle cannula (20) and a second retracted position allowing an injection to be performed. The shield (30) carries a cleaner (50) which cleans at least the tip (24) of the needle cannula (20) between successive injections such that the prefilled injection device can be used without changing the needle cannula (20) during its life cycle.

The invention relates to an injection device for injecting a liquid drug. The injection device comprises a housing assembly supporting a non-removable cartridge having an interior chamber containing the liquid drug to be injected and a reusable needle cannula connected to the cartridge. A needle shield assembly provided with a cleaning chamber containing a volume of a cleaning agent for cleaning at least the distal tip of the needle cannula between subsequent injections is further provided. The needle shield assembly is axially movable in a proximal direction in relation to the housing assembly from a first position to a second position upon rotation of at least a part of the needle shield assembly, wherein the first position is a position in which the distal tip of the needle cannula is located inside the cleaning chamber thereby cleansing the distal tip of the needle cannula, and the second position is a position in which the distal tip of the needle cannula is located outside and distal to the cleaning chamber for equalizing the pressure in the cartridge.

The present invention concerns a medical injection device for apportioning set doses of a preservative containing liquid drug. The injection device comprises a housing supporting a cartridge containing the preservative containing liquid drug and a needle cannula for transferring the liquid drug from the cartridge and through the skin of a user. Further, a needle shield which is axially movable in relation to the housing is also present. The axially movable shield carries a cleaning reservoir for cleaning at least the tip of the needle cannula between subsequent injections and the cleaning reservoir is preferably filled with preservative containing liquid drug directly from the cartridge upon initiation of the injection device. In order to eliminate any overpressure being built up inside the cleaning reservoir during the filling process, the cleaning reservoir is provided with an outlet configured to be permanently sealed by a user activated operation.

Flush syringe assemblies are described herein. Such flush syringe assembly may include a collapsible syringe barrel including a corrugated side wall defining a chamber, a closed proximal end, a distal end having a distal wall with an elongate tip extending distally therefrom having a passageway therethrough in fluid communication with said chamber, a pre-selected amount of sterile fluid in the chamber, and a locking element. A collar may be disposed on the distal wall of the barrel and surrounding the elongate tip. An absorbent material and disinfectant or antimicrobial agent may be disposed in a compartment of the collar.

Injection systems and methods of using the same are described herein. Each injection system may include one, two, or more needles, with each needle being configured to move needle between an injection position and a retracted position to deliver an inoculant. The injection needles may rotate about a carriage axis that extends through the injection axis along which each needle moves when moving between their injection and retracted positions. The injection needles in systems that include two or more injection needles may be advanced from the retracted position to the injection position at the same or different times.

The present disclosure relates generally to the field of drug delivery. In particular, the present disclosure relates to a drug delivery system that includes a sealed and sterile fluid path attached to a drug-loaded container. The disclosure further relates to methods for sterilizing a portion of the drug delivery system without exposing the drug-loaded container to harmful sterilization parameters.