A protection device for a syringe needle, having an elastomeric cap. The cap defining a housing receiving the distal portion of the body of a needle syringe. An end wall of the cap perforatable over a fraction of its thickness by the free end of the needle. The housing having a first segment of frustoconical or cylindrical shape; a cylindrical second segment for housing the distal portion of the syringe body that carries the needle, and a third segment that tapers from the second segment towards the end wall of the housing, the lateral wall provided with an annular bead arranged in the housing, at least one slot extending in a longitudinal direction across the annular bead. The second segment includes at least one axial groove that extends longitudinally over a fraction of the height of the second segment.

The present invention provides a needle unit (10, 310, 410, 510) having a proximal space (13, 513) adapted to accommodate a portion of a variable volume reservoir, the needle unit (10, 310, 410, 510) comprising: a needle carrier (15, 315, 415, 515), a needle tube (21, 121, 221, 321, 421, 521) being fixed to the needle carrier (15, 315, 415, 515) and comprising a distal needle end (23, 123, 223, 323, 423, 523) for providing fluid communication to an injection site, a needle shield (50, 350, 450, 550) carrying a sealed chamber (38, 138, 238, 338, 438, 538) for accommodating a distal portion of the needle tube (21, 121, 221, 321, 421, 521), the sealed chamber (38, 138, 238, 338, 438, 538) being sealed distally by a penetrable self-sealing septum (39, 139, 239, 339, 439, 539), and a flow channel (24, 124, 224, 324, 424, 524) for establishing fluid communication between the sealed chamber (38, 138, 238, 338, 438, 538) and the proximal space (13, 513), wherein the needle shield (50, 350, 450, 550) and the needle carrier (15, 315, 415, 515) are capable of relative motion between a first relative position in which the sealed chamber (38, 138, 238, 338, 438, 538) houses the distal needle end (23, 123, 223, 323, 423, 523), and a second relative position in which the distal needle end (23, 123, 223, 323, 423, 523) protrudes from the sealed chamber (38, 138, 238, 338, 438, 538) through the penetrable self-sealing septum (39, 139, 239, 339, 439, 539), and wherein the needle tube (21, 121, 221, 321, 421, 521) further comprises a side hole (25, 125, 225, 325, 425, 525), the side hole (25, 125, 225, 325, 425, 525) being in fluid communication with the flow channel (24, 124, 224, 324, 424, 524) and positioned within the sealed chamber (38, 138, 238, 338, 438, 538) when the needle shield (50, 350, 450, 550) and the needle carrier (15, 315, 415, 515) are in the second relative position.

A drug delivery system for injecting a medicament includes a housing defining a cavity, a container received within the cavity and configured to receive a medicament, the container comprising a stopper configured to move within the container and a closure, a drive assembly received within the cavity and configured to drive the stopper within the container, a needle actuator assembly received within the cavity and comprising a needle configured to be placed in fluid communication with the container, the needle moveable from a first position and a second position spaced from the first position, and a sterilizer received within the cavity and configured to sterilize at least one of the container, the drive assembly, and the needle actuator assembly upon activation of the drug delivery system.

A device for connection to a medical connector, the device includes a cap, a barrier wall, a first seal, a second seal, a first annular wall including a plurality of internal threads, and a second annular wall including a plurality of external threads. Also described is a device for connection to a medical connector, the device includes a cap, a first seal, a second seal, a first annular wall including a plurality of internal threads, and a second annular wall including a plurality of external threads. The cap configured to define a first chamber to contain an absorbent material and disinfectant or antimicrobial agent and a second chamber to contain an absorbent material and disinfectant or antimicrobial agent. The cap includes one or more internal threads adapted to engage with a female luer connector. The cap also includes one or more external threads adapted to engage with a male luer connector. The first seal and the second seal prevent the disinfectant or the antimicrobial agent from exiting the first chamber and the second chamber.

A method for sterilizing a drug delivery device may comprise disposing a liquid drug container, a needle conduit and a cap in a sterilization enclosure so that a mouth portion of the liquid drug container is registered with, and spaced apart from, a circumferential lip of the cap; disposing a cover over the liquid drug container, the needle conduit, and the cap, sealing the sterilization enclosure; subjecting the interior of the sterilization enclosure to a sterilization process in which the liquid drug container, the needle conduit, and the cap are exposed to the sterilization fluid and are sterilized; and applying a downward force to the liquid drug container to move the mouth portion into engagement with the circumferential lip of the cap and to snap the cap onto the liquid drug container to seal the cap and needle conduit to the liquid drug container in an assembled configuration.

A container includes an upper opening portion, a holder, which is placed in the container, for holding at least one medical device, and a gas non-permeable film for sealing the opening portion. The holder includes a basal plate portion having a plate shape, a plurality of tubular portions protruding downwardly from the basal plate portion, a plurality of stays formed around each of the plurality of tubular portions and connecting another of the plurality of tubular portions, and a support rod protruding downwardly from the basal plate portion and having a length longer than the plurality of tubular portions. The support rod is arranged such that a medical device housed in each of the plurality of tubular portions is not adapted to contact a bottom surface of the container, or another holder adjacent to the holder when the holder and the another holder are stacked.

An on-body injector system includes a drug container assembly including a container, a seal member, and a sealing interface between the seal member and the container. The container includes an opening and the seal member at least partially covers the opening in the container. A fluid pathway assembly is coupled to the drug container assembly and includes a needle that is movable between a storage position, in which a point of the needle is spaced from the seal member, and a delivery position, in which the point of the needle is disposed at least partially through the seal member. A radiation generator is configured to emit rays of radiation to sterilize and/or disinfect the sealing interface. A barrier is disposed adjacent to the sealing interface and has an opening. At least a portion of the drug container assembly is positioned adjacent to the opening in the barrier.

A drug delivery system for injecting a medicament includes a housing defining a cavity, a container received within the cavity and configured to receive a medicament, the container comprising a stopper configured to move within the container and a closure, a drive assembly received within the cavity and configured to drive the stopper within the container, a needle actuator assembly received within the cavity and comprising a needle configured to be placed in fluid communication with the container, the needle moveable from a first position and a second position spaced from the first position, and a sterilizer received within the cavity and configured to sterilize at least one of the container, the drive assembly, and the needle actuator assembly upon activation of the drug delivery system.

An injection device is provided, including a syringe having a barrel and a flange and a backstop configured to be coupled with the syringe adjacent to the flange. The backstop includes an inner surface generally extending around at least a portion of the syringe, wherein the inner surface includes at least one protrusion extending away from the inner surface and configured to engage the flange and/or the barrel to permit or promote airflow through a space between the inner surface and the syringe.

Apparatus and a method are presented, including disinfecting a disinfection chamber (34) that is defined between (i) a prefilled therapeutic substance reservoir (32) and (ii) a sterile fluid path (22) disposed within a therapeutic substance delivery device (20). The sterile fluid path includes a needle (26) at an upstream end (24) of the sterile fluid path and an injection assembly (30) at a downstream end (28) of the sterile fluid path. Subsequently to disinfecting the disinfection chamber, the disinfection chamber and then the reservoir are penetrated with the needle. Other applications are also described.