A hard package assembly is disclosed having a cam mechanism for ejecting a syringe from a hard package container with the use of a single hand. The cam mechanism including a push button and a button retainer, the push button having a trapezoidal body having a button face, a distal face adjacent and distal to the button face and a sloped face opposite the button face, the button retainer having a proximal portion, a distal portion in contact with the sloped face of the push button and a distal hook in contact with a bottom surface of the barrel flange. A method of use and a method of assembly are also disclosed.

A prepackaged injectable pharmaceutical composition includes a sealed outer package made of a material having a low oxygen transmission rate and an inner package disposed within the sealed outer package. The inner package is configured to provide an indication that the inner package has been opened after being closed. A prefilled syringe is disposed within the inner package. The syringe includes a barrel comprising a polymeric material and a dose of the injectable pharmaceutical composition.

Methods, assays, compositions and kits for the ligation of short polynucleotides are presented herein. The short polynucleotides are optionally no more than 7 nucleotides in length, and can be as short as 3 or 4 nucleotides in length. The ligation is optionally performed by CV ligase.

The invention relates to an auto injector, by which a fixed dose of a medicament can be injected as self-treatment, and by which needle exposure to an accessible position, injection of the medicament and retraction of the needle to an inaccessible position is automatically performed as a continuous sequence, after the auto injector is triggered. The invention provides solutions to improve the functionality of the retraction of the needle and the general experience of the use.

A liquid formulation of an ophthalmic drug in a pharmaceutical package, for example a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer.

Aspects and embodiments of the present invention generally include a device for patient self-administration of a prescribed medication. The device makes available for administration the precise quantity of medication constituting a dose at times designated by a health care provider (HCP). Preferably, the device also detects and transmits information to a remote management system accessible to the HCP, including detected attempts to tamper with the device. Advantageously, HCPs may render oversight and control over the device and its use to mitigate risks associated with patients self-administering medication without in-person supervision. This control may include establishing prerequisites the patient must meet prior to a dose being made available, or remote deactivation of the device. This oversight by the HCP may include patient-specific and aggregate data analysis for optimization of treatment or evaluation of the safety and efficacy of a treatment. Furthermore, this oversight may be conducted via a web-based interface.

The disclosure relates to a drug delivery device including: a housing configured to contain a drug container with a needle, a needle shroud that is telescopically connected to the housing, and a cap that is configured to be releasably connected to the housing before use of the device. At least one of the cap and the needle shroud is adapted to unreleasably lock the cap onto the housing after reapplying the cap onto the housing after the drug delivery device is used.

A pen needle (30) for a delivery device includes a hub (32) supporting a needle (54) and a distal needle shield (70) that can retract to expose the needle during injection and return to the extended position after use and lock in the extended position to cover the needle. A proximal needle shield (0.102) moves from a retracted position to an extended position with respect to the hub to shield or cover a proximal end of the needle when the needle hub is separated from the delivery device. A spring (130) extends between the distal needle shield and the proximal needle shield to bias each needle shield to the respective extended position. The distal needle shield (70) is coupled to the proximal needle shield (102) in an initial position to retain the spring (130) in a compressed state. The distal needle shield (70) is depressed to disengage the distal needle shield from the proximal needle shield (102) so that the spring expands to an extended state and moves the shields to the extended positions. A locking member (142, 156) can be provided to lock the proximal needle shield (70) and distal needle shield (102) in the extended position.

A pen needle (30) for a delivery device includes a hub (32) supporting a needle (54) and a distal needle shield (70) that can retract to expose the needle during injection and return to the extended position after use and lock in the extended position to cover the needle. A proximal needle shield (0.102) moves from a retracted position to an extended position with respect to the hub to shield or cover a proximal end of the needle when the needle hub is separated from the delivery device. A spring (130) extends between the distal needle shield and the proximal needle shield to bias each needle shield to the respective extended position. The distal needle shield (70) is coupled to the proximal needle shield (102) in an initial position to retain the spring (130) in a compressed state. The distal needle shield (70) is depressed to disengage the distal needle shield from the proximal needle shield (102) so that the spring expands to an extended state and moves the shields to the extended positions. A locking member (142, 156) can be provided to lock the proximal needle shield (70) and distal needle shield (102) in the extended position.

To prevent accidental needle stick injuries, a syringe has a plunger configured to pull the syringe into the syringe barrel after clinical use. The syringe has an additional safety feature that restricts subsequent movement of the plunger. After the needle has been retracted in its entirety within the barrel of the syringe, movement of the plunger is restricted by a two-part locking mechanism, a notch on the plunger and a T-shaped slot on the barrel with a one-way catch section to prevent the needle tip from being pushed accidentally through the barrel wall.