Systems and methods for creating microneedle arrays capable of delivering a suitable drug dosages to subjects are provided. In one aspect, a method comprises creating at least one forming mold using laser ablation in a cross-over line pattern. The method further comprises casting a first material onto the at least one forming mold to create at least one microneedle mold. The method further comprises casting a second material onto the at least one microneedle mold to create at least one hollow microneedle.

Methods for fabricating composite tools and composite tools are provided. In an exemplary embodiment, a method for fabricating a composite tool includes providing a master mold and forming a low temperature cured resin laminate overlying the master mold. The low temperature cured resin laminate is heated and compressed to form a cured low temperature cured resin laminate, the low temperature cured resin laminate heated to a first temperature. The cured low temperature cured resin laminate is removed from the master mold and a high temperature cured resin laminate is formed overlying the cured low temperature cured resin laminate. The high temperature cured resin laminate is heated and compressed to form a cured high temperature cured resin laminate. The high temperature cured resin laminate is heated to a second temperature, wherein the second temperature is higher than the first temperature.

A system and method for the manufacture of wind turbine blade moulds and wind turbine blade mould plugs is described. The method comprises dividing a blade mould geometry (70) or plug geometry into separate geometrical slices or segments. The separate slices can then be used to control a cutting of blank elements (78) to form separate cut surfaces (82). The cut surfaces are used to form a consolidated wind turbine mould surface.

A system and method for the manufacture of wind turbine blade moulds and wind turbine blade mould plugs is described. The method comprises dividing a blade mould geometry (70) or plug geometry into separate geometrical slices or segments. The separate slices can then be used to control a cutting of blank elements (78) to form separate cut surfaces (82). The cut surfaces are used to form a consolidated wind turbine mould surface.

The present invention relates to a method for fabricating a composite construction element using a mould fabricated by a computer-controlled apparatus. The method comprises the steps of fabricating the mould having one or more receiving portions dimensioned to receive one or more respective objects responsive to computer instructions relating to the mould geometry, positioning the one or more objects in respective receiving portions, covering at least a portion of the mould and the one or more objects with settable material, and at least partially curing the settable material, thereby forming the composite construction element having the one or more objects embedded therein.

The present invention relates to a method for fabricating a composite construction element using a mould fabricated by a computer-controlled apparatus. The method comprises the steps of fabricating the mould having one or more receiving portions dimensioned to receive one or more respective objects responsive to computer instructions relating to the mould geometry, positioning the one or more objects in respective receiving portions, covering at least a portion of the mould and the one or more objects with settable material, and at least partially curing the settable material, thereby forming the composite construction element having the one or more objects embedded therein.

Methods for mass production of new microfluidic devices are described. The microfluidic devices may include an array of micro-needles with open channels in fluid communication with multiple reservoirs located within a substrate that supports the micro-needles. The micro-needles are configured so as to sufficiently penetrate the skin in order to collect or sample bodily fluids and transfer the fluids to the reservoirs. The micro-needles may also deliver medicaments into or below the skin.

Methods for mass production of new microfluidic devices are described. The microfluidic devices may include an array of micro-needles with open channels in fluid communication with multiple reservoirs located within a substrate that supports the micro-needles. The micro-needles are configured so as to sufficiently penetrate the skin in order to collect or sample bodily fluids and transfer the fluids to the reservoirs. The micro-needles may also deliver medicaments into or below the skin.

A tool including a tool body, the tool body including a substrate having a tool-side surface, an intermediate layer positioned over the tool-side surface, and an outer layer positioned over the intermediate layer, the outer layer including a metallic material.

A tool including a tool body, the tool body including a substrate having a tool-side surface, an intermediate layer positioned over the tool-side surface, and an outer layer positioned over the intermediate layer, the outer layer including a metallic material.