A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.

A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.

A nebulizer device includes an air intake port positioned downstream of a nebulizer element, and a mouthpiece positioned upstream of the nebulizer element. A flow sensor is coupled to a controller. The controller is configured to integrate an inhaled air flow signal received from the flow sensor for determining an inhaled air volume. The controller is also configured to turn on the nebulizer element when the inhaled air volume reaches a first predetermined threshold, and turn off the nebulizer element when the inhaled air volume reaches a second predetermined threshold. A method for targeted delivery of aerosolized particles to the lungs is also disclosed.

An ultrasonic nebulizer is provided that has a liquid chamber to receive a liquid. A piezoceramic transducer is attached to one end of the liquid chamber. The piezoceramic has an orifice to allow the liquid inside the chamber to exit. A plunger movably and sealbly is inserted into the liquid chamber from its other end, which is moved by a moving mechanism to push the liquid out of the liquid chamber. The plunger forms a small liquid droplet on the surface of the piezoceramic. Oscillation of the piezoceramic at megahertz frequencies results in atomization and formation of small droplets from the surface of the sessile droplet. The present nebulizer is a total consumption nebulizer, since all its droplets are substantially within 2 to 5 microns, which is the size range to penetrate into the lunges of a user.

An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.

A nebulizer is provided to atomize a liquid medication for rapid delivery of an aerosol spray to a user via inhalation. The nebulizer includes a jar having a compressed gas passage. A jet cooperates with the jar and has a jet orifice through which the liquid medication and the compressed gas are discharged to form an aerosol flow. The cap is connected to the jar to define an inner chamber. The cap includes an entrainment port for ambient room air, and a chimney in fluid communication with the entrainment port and the inner chamber. A deflector base having an impingement member is located adjacent to the entrainment chimney and is spaced below an opening thereof by a predetermined distance to provide a flow of the ambient room air to be entrained in the aerosol flow in order to enhance nebulization speed while maintaining a desired aerosol particle size.

Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.

An ultrasonic nebulizer is provided that has a liquid chamber to receive a liquid. A piezoceramic transducer is attached to one end of the liquid chamber. The piezoceramic has an orifice to allow the liquid inside the chamber to exit. A plunger movably and sealbly is inserted into the liquid chamber from its other end, which is moved by a moving mechanism to push the liquid out of the liquid chamber. The plunger forms a small liquid droplet on the surface of the piezoceramic. Oscillation of the piezoceramic at megahertz frequencies results in atomization and formation of small droplets from the surface of the sessile droplet. The present nebulizer is a total consumption nebulizer, since all its droplets are substantially within 2 to 5 microns, which is the size range to penetrate into the lunges of a user.

Methods and devices for delivering one or more substances within at least one body cavity are provided. The device includes at least one nosepiece including at least one capsule having a volume V.sub.sub of the substances; at least one base in communication with the nosepiece, the base including at least one chamber configured to confine pressurized fluid at volume V.sub.PF and pressure P.sub.PF; and at least one hollow puncturing member. The hollow puncturing member includes at least one end in fluid communication with the nosepiece and a second end in fluid communication with the base. The first and second ends are fluidly interconnected by a hollow tube. The fluid inlet port of the capsule is configured in terms of size and shape to interface in a sealable manner with the one end of the at least one puncturing member.

A nebulizer has an aperture plate, a mounting, an actuator, and an aperture plate drive circuit (2-4). A controller measures an electrical drive parameter at each of a plurality of measuring points, each measuring point having a drive frequency; and based on the values of the parameter at the measuring points makes a determination of optimum drive frequency and also an end-of-dose prediction. The controller performs a short scan at regular sub-second intervals at which drive current is measured at two measuring points with different drive frequencies. According to drive parameter measurements at these points the controller determines if a full scan sweeping across a larger number of measuring points should be performed. The full scan provides the optimum drive frequency for the device and also an end of dose indication.