The present invention provides a method for producing condensation aerosols for the treatment of disease and/or chronic, intermittent or acute conditions. These condensation aerosols are produced from drugs including temperature sensitive drugs and small molecule drugs that are coated onto a foil substrate which is heated via electrical resistance heating at precisely controlled temperature profiles with controllable ramp-up and heating rates to vaporize the coated drug which subsequently condenses to form aerosol particles. These condensation aerosols have little or no degradation products. Kits comprising a drug and a device for producing a condensation aerosol are also provided. Also disclosed, are methods for using these aerosols and kits and methods of making the aerosols.

An atomization apparatus includes: an atomization sheet for atomizing a drug and having a rated voltage; and a voltage control element, electrically connected to the atomization sheet, for providing a operating voltage for the atomization sheet, wherein the operating voltage is not less than 70 V, and the operating voltage is 60% to 150% of the rated voltage of the atomization sheet, or the ratio of the operating voltage to the rated voltage of the atomization sheet is greater than 100% and not greater than 150%. A quick atomization method includes: providing an operating voltage to an atomization sheet, wherein the operating voltage is not less than 70 V, and the operating voltage is 60% to 150% of a rated voltage of the atomization sheet, or the ratio of the operating voltage to the rated voltage of the atomization sheet is greater than 100% and not greater than 150%.

A pulmonary delivery apparatus (10) comprising: a first chamber (15) adapted to thermally vaporise a quantity of a first liquid to form a relatively warm first vapour (B) and a second chamber (16) adapted to atomize a quantity of a second liquid without heating of the second liquid to form a mist of a relatively cold second vapour (A), and an outlet (30) via which, in use, a user can inhale a mixture of the first and second vapours. An active ingredient such as nicotine is provided in the second chamber and an inert liquid in the first chamber.

An assembly for a spray device is presented where the assembly has a cartridge containing a liquid to be pressurised, and a micro nozzle configured to produce an aerosol from the pressurised liquid, wherein the micro nozzle is permanently attached to the cartridge.

This application relates to an injector in which when a solution containing biomolecules is injected into an injection target, a proportion of biomolecules that function in the injection target with respect to the injected biomolecules is large. This application also relates to a method of injecting a solution containing biomolecules into an injection target using the injector. In one aspect, the injector injects the solution containing biomolecules into the injection target from an injector main body without performing injection through a given structure in a state where the given structure is inserted into the injection target. The injector may include an accommodation unit and a nozzle unit, wherein the injector satisfies a given condition.

A device for generating a condensation aerosol includes (a) vaporization chamber having an upstream first inlet and a downstream outlet; (b) a heater element in the vaporization chamber between the upstream first inlet and the downstream outlet; (c) an airflow path in fluid communication with the vaporization chamber, wherein the airflow path comprises a second inlet configured to permit a substantially laminar flow of air into the airflow path, wherein the second inlet is downstream of the heater element; and (d) the device having components or apparatus on or in the device for changing air flow in the vaporization chamber. Changing the air flow in the vaporization chamber may be used to change the particle size of a condensation aerosol produced in the vaporization chamber, and/or to change the amount of visible vapor emitted from the device.

The present invention provides a method and apparatus for controlling a patient's body temperature and in particular for inducing therapeutic hypothermia. Various embodiments of the system are described. The system includes: a source of breathing gas, which may be in the form of a compressed breathing gas mixture; a heat exchanger or other heating and/or cooling device; and a breathing interface, such as a breathing mask or tracheal tube. Optionally, the system may include additional features, such as a mechanical respirator, a nebulizer for introducing medication into the breathing gas, a body temperature probe and a feedback controller. The system can use air or a specialized breathing gas mixture, such as He/O.sub.2 or SF/O.sub.2 to increase the heat transfer rate. In addition, the system may include an ice particle generator for introducing fine ice particles into the flow of breathing gas to further increase the heat transfer rate.

The invention relates to a spray device having a spray nozzle unit and at least one further spray nozzle unit. Each spray nozzle unit has at least one spray nozzle body, wherein said at least one spray nozzle body comprises a chamber for receiving a pressurized fluid. Said chamber is bounded by a spray wall having at least one spray orifice that extends through said spray wall and opens to an external environment. Each of said at least one orifice in a spray wall has a substantially identical predetermined size lying in a predetermined range and releases a mono disperse spray jet of the pressurized fluid fed from the associated reservoir. Said range within said first spray nozzle unit differs from said range within said at least one further spray nozzle unit, particularly said ranges do not overlap.

The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to a fixture for a nebulizing nozzle to be used in such an inhalation device. A nozzle fixing assembly (1) for an inhalation device, comprising an elastically deformable seal element (2), having a continuous opening (3) capable of receiving a nozzle body (4), said seal element (2) and said nozzle body (4) each having a high pressure side (2A, 4A) and an outlet side (2B, 4B); and a pressure element (5) with a high pressure side (5A), said side being arranged to face the high pressure side (2A) of the seal element (2); wherein (i) the high pressure side (2A) of the seal element (2) is substantially flat, and (ii) the high pressure side (5A) of the pressure element (5) is chamfered in a way that, in the assembled state, the distance between these high pressure sides (2A, 5A) is higher in a central region (C) than in a peripheral region (P).

A disposable cartridge is disclosed for use with an electronic device for producing an aerosol for inhalation by a person. The cartridge comprises a liquid container containing a liquid which when aerosolized is intended for inhalation by a person; and a transducer that, when actuated, causes the liquid from the container to be aerosolized such that the aerosol may be inhaled by a person. In various embodiments, the liquid comprises: a liposomal carrier; a liquid mixture having an active agent entrapped by liposomes; and a liquid mixture comprising a nanodispersion. The liquid may include nicotine, tetrahydrocannabinol, cannabidiol, or nanoparticles formed by an oil droplet covered by a monolayer of phosphatidylcholine. The transducer preferably comprises a mesh material with the transducer and the mesh material forming a piezo mesh disk for aerosolizing the liquid.