Devices and systems for delivering an aerosolized reperfusion-injury-modifying drug (RIMD) to a patient are described. In an embodiment, the devices include an RIMD; an aerosolizer in fluid communication with the RIMD configured to aerosolize the RIMD to provide an RIMD aerosol; and an exit port configured to direct the RIMD aerosol for receipt by the patient. In an embodiment, the systems include a ventilator configured to generate airflow and coupled to the exit port. Methods for delivering an aerosol comprising an RIMD to a patient are also described. In an embodiment, the methods include aerosolizing an RIMD to provide an RIMD aerosol comprising RIMD droplets; and introducing the RIMD aerosol into an inhalation airflow of the patient.

In one embodiment, the electronic vaping device includes a cartridge and a battery section. The cartridge and the battery section are connectable so as to define an air inlet between a portion of the cartridge and a portion of the battery section.

An object of the present invention is to provide a powder preparation and the like suitable for selective administration to an olfactory region and the like. The object is achieved by a powder preparation for selectively administering an active ingredient to an olfactory region in a nasal cavity, the powder preparation comprising the active ingredient and having a bulk density of 0.1 to 0.5 g/cm.sup.3 and a Hausner ratio of 1.6 to 2.4.

Embodiments of the invention disclose a combined ultrasonic atomizer, an atomization method thereof and electronic cigarette. The combined ultrasonic atomizer comprises a tobacco tar bin, an air inlet passage, a tobacco tar smoke outlet passage and an atomization component; the atomization component comprises a micropore atomization piece used for performing first-stage oscillation atomization on tobacco tar and a high-frequency atomization piece used for performing second-stage oscillation atomization on the tobacco tar; the micropore atomization piece is communicated with a tobacco tar outlet of the tobacco tar bin by direct contact or through a tobacco tar guide structure, and an ejection end of the micropore atomization piece is aligned to an atomization surface of the high-frequency atomization piece; and the air inlet passage communicates with an atomization cavity located between the micropore atomization piece and the high-frequency atomization piece, and the atomization cavity communicates with the tobacco tar smoke outlet passage.

A system for treating or providing prophylaxus against a pulmonary infection is disclosed comprising: a) a pharmaceutical formulation comprising a mixture of free antiinfective and antiinfective encapsulated in a lipid-based composition, and b) an inhalation delivery device. A method for providing prophylaxis against a pulmonary infection in a patient and a method of reducing the loss of antiinfective encapsulated in a lipid-based composition upon nebulization comprising administering an aerosolized pharmaceutical formulation comprising a mixture of free antiinfective and antiinfective encapsulated in a lipid-based composition is also disclosed.

Described is a dry powder inhaler for inhalation of a dry powder composition. The inhaler includes an external housing that defines an internal passage. The inhaler also includes a mouthpiece, a compartment for holding a dry powder capsule or powder reservoir, and a powder fluidization and deagglomeration apparatus for directing airflow to the dry powder to generate airborne powder particles within the internal passage. When a user inhales through the mouthpiece, a first airflow pattern is generated that has a first airflow resistance, during which the fluidization and deagglomeration apparatus generates airborne dry powder particles within the internal passage. Upon reaching a threshold negative pressure value within the internal passage of the inhaler, a second airflow pattern is generated having a second airflow resistance that is lower than the first airflow resistance, which pulls the airborne dry powder into the user's lungs during the inhalation. Embodiments of elastomeric valves are also described.

A thermally modulating inhalable medicament delivery device may deliver an inhalable medicament as an aerosol, vapor, or partial aerosol and partial vapor mixture. The inhalable medicament may be delivered to a target in a subject. Described herein are devices, systems, and methods for delivering an inhalable medicament to a subject.

A method of delivering aerosolized surfactant to an infant that includes interfacing an aerosolization device with an airway of an infant and aerosolizing, using the aerosolization device, a volume of surfactant into particles having a mass mean aerodynamic diameter (MMAD) of less than about 3 m at a rate of at least 0.1 ml/min. The surfactant is aerosolized within about 1 to 8 cm from a patient interface. Aerosol is generated for up to approximately 80% or each inspiration. The method also includes delivering the aerosolized surfactant to the infant's airway.

An aerosolization system includes a respiration system having an inspiratory limb and an expiratory limb. The system includes an aerosol chamber coupled with the inspiratory limb via a fluid channel. The fluid channel is disposed such that the aerosol chamber is isolated from continuous flow passing through the respiratory system. The system includes a patient interface positioned at a first location of the aerosol chamber and an aerosolization device positioned at a second location of the aerosol chamber positioned opposite the first location. The aerosolization device includes a reservoir that receives a volume of liquid medicament for aerosolization by the aerosolization device. The aerosol chamber mixes aerosolized medicament from the aerosolization device with respiratory flow received from the respiration system via the fluid channel.

Liquid formulations of insulin that contain physically and chemically stable insulin but do not contain preservatives or stabilizers are provided. The formulations also lack surfactants. The formulations are useful for various modes of delivery including pulmonary delivery.