Methods for making a microstructured tool having interspersed topographies are disclosed, and the production of articles therefrom. The article has a major surface including first microstructural features and second microstructural features arranged in a pattern visible at least when viewed normal to the first major surface. The first and second microstructural features are different relative to each other, and are selected from the group consisting of cones, diffraction gratings, lenticulars, segments of a sphere, pyramids, cylinders, fresnels, and prisms.

The present invention relates to a microstructure including a biocompatible polymer or an adhesive and to a method for manufacturing the same. The present inventors optimized the aspect ratio according to the type of each microstructure, thereby ensuring the optimal tip angle and the diameter range for skin penetration. Especially, the B-type to D-type microstructures of the present invention minimize the penetration resistance due to skin elasticity at the time of skin attachment, thereby increasing the penetration rate of the structures (60% or higher) and the absorption rate of useful ingredients into the skin. In addition, the D-type microstructure of the present invention maximizes the mechanical strength of the structure by applying a triple structure, and thus can easily penetrate the skin. When the plurality of microstructures are arranged in a hexagonal arrangement type, a uniform pressure can be transmitted to the whole microstructures on the skin.

Disclosed herein is a microneedle array comprising a substrate and a plurality of microneedles extending therefrom, wherein the microneedles comprise a biodegradable polymer and an effective amount of an analgesic or an anti-inflammatory therapeutic agent. Methods of using and making the microneedle array are also disclosed.

Process and mold embodiments are described herein for creating polyurethane molds that allow for the production of manhole bases.

A therapeutic device and a method of making a therapeutic device. The therapeutic device has a body portion having a first end, a second end, a first end portion, a second end portion, and an intermediate portion interposed between the first and second end portions. Extending inward into at least a portion of the body portion of the therapeutic device from at least a portion of the first end of the therapeutic device is a receiving portion. At least a portion of a surface defining the receiving portion has a shape needed to apply a suction force onto another object needed to secure at least a portion of the object within the receiving portion of the therapeutic device.

Provided herein is a hierarchical superhydrophobic surface comprising an array of first geometrical features disposed on a substrate comprising a first material, and an array of second geometrical features disposed on the first features to form a hierarchical structure and a terminal level disposed on the second features, wherein the terminal level comprises a second material, the second material being different from the first material. The second material has a hydrophilicity different from the hydrophilicity of at least one of 1) the hydrophilicity of the second material and 2) hydrophilicity induced by the hierarchical structure. The present disclosure further methods of preparing hierarchical superhydrophobic surfaces and medical devices comprising the hierarchical superhydrophobic surfaces.

Disclosed are various embodiments for forming an odor control item and providing packaging for an odor control item. A method for forming at least one odor control item includes providing a resealable package comprising a first blister and a second blister, wherein the first blister comprises at least one cavity, performing a hot mold process whereby a liquid substance is poured into the at least one cavity, and curing the liquid substance while the liquid substance is in the at least one cavity to form the at least one odor control item.

The present disclosure relates to a method for producing microneedle arrays in a mold, including a plurality of receptacles that taper from an upper base surface to a lower tip surface, where a first component is fed into at least two receptacles through a feed opening that is spaced apart from the base surface, where the receptacles are filled with an additional component from above the feed opening, where the fillings of at least said two receptacles, which fillings are formed of at least the first component and the additional component, are connected to one another above the base surfaces, and where after the first component and the additional component have solidified, the microneedle array comprising the fillings that have solidified to form needles is removed from the mold.

A cryo formulation-based microneedle device for transdermal delivery of bioactive therapeutic agents. The microneedle device includes: one or more microneedle patches each including an array of miniaturized needles, wherein each miniaturized needle defining a base end and a tip; and a substrate to which the base end of the array of miniaturized needles is attached or integrated thereto; wherein the microneedle patch is in a cryo status; wherein each of the one or more microneedle patch is adapted to be applied on a skin surface, in which the miniaturized needles penetrates into skin; and wherein the miniaturized needles is further arranged to melt so as to release one or more bioactive therapeutic agents into the skin to achieve a targeted therapeutic effect.

A method of forming a polymer is disclosed. The method comprises: positioning a mould in relation to a bath containing a molten material to form a mould cavity between the mould and the molten material; adding a monomer within the mould cavity; and curing the monomer to form a polymer.