The subject matter of the present invention is a device for guiding cell migration comprising a substrate having a textured surface intended to be brought into contact with cells, said textured surface having an anisotropic three-dimensional structure consisting of a network of projections inclined relative to the normal to the plane formed by said textured structure, in the direction imparted by said anisotropic structure. The invention also concerns, according to another aspect, a method for guiding cell migration including the bringing into contact of cells with a substrate having a textured surface and an anisotropic three-dimensional structure, said structure consisting of projections inclined as previously described. The device or method according to the invention can in particular be applied in the fields of dermatology, implantology and tissue engineering.

The subject matter of the present invention is a device for guiding cell migration comprising a substrate having a textured surface intended to be brought into contact with cells, said textured surface having an anisotropic three-dimensional structure consisting of a network of projections inclined relative to the normal to the plane formed by said textured structure, in the direction imparted by said anisotropic structure. The invention also concerns, according to another aspect, a method for guiding cell migration including the bringing into contact of cells with a substrate having a textured surface and an anisotropic three-dimensional structure, said structure consisting of projections inclined as previously described. The device or method according to the invention can in particular be applied in the fields of dermatology, implantology and tissue engineering.

A composite material molding method is provided for forming a composite material. The molding includes disposing carbon fiber in a cavity inside an openable and closable mold, injecting resin into the cavity in a state in which a clamping pressure is exerted on the mold and curing the resin. When a threshold value of the pressure inside the cavity is set to a pressure that is lower than the clamping pressure and the resin is injected into the cavity while exerting an injection pressure that is equal to or greater than the clamping pressure on the resin until the pressure inside the cavity reaches the threshold value. Then, after the pressure inside the cavity has reached the threshold value, the inside of the cavity is suctioned.

A composite material molding method is provided for forming a composite material. The molding includes disposing carbon fiber in a cavity inside an openable and closable mold, injecting resin into the cavity in a state in which a clamping pressure is exerted on the mold and curing the resin. When a threshold value of the pressure inside the cavity is set to a pressure that is lower than the clamping pressure and the resin is injected into the cavity while exerting an injection pressure that is equal to or greater than the clamping pressure on the resin until the pressure inside the cavity reaches the threshold value. Then, after the pressure inside the cavity has reached the threshold value, the inside of the cavity is suctioned.

An additive manufacturing method includes removing material from a sheet to create a plurality of individual layer segments formed, placing at least two first layer segments adjacent to each other at the same height to form a first layer having a hollow interior, the at least two first layer segments defining a first portion of an exterior of a part, and placing at least one second layer segment above the at least two first layer segments to form a second layer having a hollow interior, the at least one second layer segment defining a second portion of the exterior of the part. The method includes attaching the first layer to the second layer and removing material from the first layer and from the second layer to form the part having a continuous surface that extends along the first layer and the second layer.

Systems and methods for creating microneedle arrays capable of delivering a suitable drug dosages to subjects are provided. In one aspect, a method comprises creating at least one forming mold using laser ablation in a cross-over line pattern. The method further comprises casting a first material onto the at least one forming mold to create at least one microneedle mold. The method further comprises casting a second material onto the at least one microneedle mold to create at least one hollow microneedle.

A flat-pressing manufacturing method of a bionic adhesive structure based on a micro through-hole nickel-based mold is disclosed. The method includes the following steps: preparing a nickel-based mold with a micro through-hole array; placing the nickel-based mold on an elastic pad in a magnetic mold closing system; coating a liquid prepolymer uniformly on a backing, and placing a side of the backing coated with the liquid prepolymer on the nickel-based mold, covering a sealing diaphragm on the backing to separate a cavity into an upper chamber and a lower chamber, and performing a vacuum treatment on the lower chamber and an inflation treatment on the upper chamber to apply a uniform pressure on the backing layer and achieve a full filling of prepolymers with different viscosities; and after the filling is completed, curing and demolding to obtain the bionic adhesive structure.

A method for manufacturing a molded product with fine structure includes steps of, in a temperature-controlled stamper mold provided with a fine structure including a concavo-convex pattern having a width of 10 nm to 1 μm, forming a thermoplastic molten polymer layer to be in contact with the fine structure 20 of the stamper mold having been kept at a predetermined temperature and holding the thermoplastic molten polymer layer for a predetermined time so as to transfer the fine structure of the stamper mold to the thermoplastic molten polymer layer under gravity.

A method for manufacturing a molded product with fine structure includes steps of, in a temperature-controlled stamper mold provided with a fine structure including a concavo-convex pattern having a width of 10 nm to 1 μm, forming a thermoplastic molten polymer layer to be in contact with the fine structure 20 of the stamper mold having been kept at a predetermined temperature and holding the thermoplastic molten polymer layer for a predetermined time so as to transfer the fine structure of the stamper mold to the thermoplastic molten polymer layer under gravity.

Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.