A pharmaceutical drug delivery device and method of using the pharmaceutical drug delivery device. The pharmaceutical drug delivery device includes a cartridge body; a fluid outlet nozzle attached to the cartridge body; and a fluid jet ejection cartridge disposed in the cartridge body, wherein the cartridge contains a liquid pharmaceutical drug and a fluid ejection head containing a plurality of fluid ejection nozzles and associated fluid ejectors. A processor disposed on a logic board or fluid ejection head is provided for executing a control algorithm to control the ejection head to modify plume characteristics of fluid ejected from the ejection head by controlling one or more of fluid jet firing frequency, burst length, and fluid jet firing burst delay.

Provided herein is a method of pulmonary delivering to a subject at least one pharmacologically active agent being in a plant material, which is effected by pulmonary delivering the agent to the subject using a metered dose inhaler device that is configured to vaporize at least one pre-determined vaporized amount of the agent upon controllably heating the plant material, wherein the pre-determined vaporized amount is selected so as to achieve at least one pre-determined pharmacokinetic effect and/or at least one pre-determined pharmacodynamic effect induced by the agent in the subject.

Substance supply apparatus, systems and methods are provided herein. In some aspects, a substance supply apparatus comprises a tank assembly coupled to a manifold. The tank assembly can comprise a cavity housing one or more electrical components, a set of heating elements electrically coupled to the electrical components, and wherein each heating element is configured to couple with a cartridge configured to house a substance to be heated. The manifold can comprise a plurality of delivery ports, wherein each delivery port is configured to couple with a cartridge that is also coupled to the heating element. In some aspects, a system comprises one or more supply apparatus, as well as one or more inhalation chambers, actuator devices, supply paths from the apparatus to an inlet port of the chambers, and one or more controllers.

A pharmaceutical drug delivery device and method of preventing drying out and drooling of an ejection head for the drug delivery device. The device includes a drug delivery device body; a fluid outlet nozzle attached to the drug delivery device body; and a fluid jet ejection cartridge containing a liquid pharmaceutical drug disposed in the drug delivery device body. A fluid ejection head is attached to the fluid jet ejection cartridge and the fluid ejection head is in fluid flow communication with the fluid outlet nozzle. An elongate, serpentine air flow path is provided between and outer surface of the fluid jet ejection cartridge and an inner surface of the fluid outlet nozzle. The elongate, serpentine air flow path provides a reduced pressure differential adjacent to a surface of the fluid ejection head upon use of the drug delivery device and provides a humidification zone.

A dose unit including at least one isolated bioactive agent applied on a carrier material in thermal contact with an electrically heating element configured to vaporize a pre-determined amount of the agent for pulmonary delivery thereof is provided herein, as well as devices for effecting vaporization and pulmonary delivery of the isolated agent, and methods for preparing the dose unit, controllably releasing the agent therefrom, methods for pulmonary delivery thereof and methods of treatment of medical conditions treatable by pulmonary delivery of the isolated bioactive agent.

An aerosol-generating system is provided, including: an aerosol-generating device including a power source; and a cartridge removably coupled to the aerosol-generating device, the cartridge including: a liquid storage portion including a housing having an open end and containing a liquid aerosol-forming substrate, a heater assembly at the open end of the housing and including a planar electrical heating element to heat the liquid aerosol-forming substrate to form an aerosol, and a capillary material in contact with the planar electrical heating element and being configured to convey the liquid aerosol-forming substrate to the planar electrical heating element, the liquid storage portion being at a first side of the heater assembly and an airflow channel being at a second side of the heater assembly, and the power source of the aerosol-generating device is to supply power to the heater assembly.

A unit dose container for holding a single dose of a given liquid, the container comprising: a chamber (8) in which, in use, the given liquid is stored, the chamber having a wall through which, in use, the liquid is to be supplied; a release mechanism (7), at least part of which is internal to, or forms part of the wall of the chamber, the release mechanism being movable relative to the chamber between first and second positions; and means for allowing the release mechanism (7) to move from the first to the second positions, thereby opening a passage through the wall so that the liquid can exit the chamber (8), the means including at least one flexible wall portion.

An inhaler system suitable for providing nicotine particles includes a mouthpiece portion removably coupled to a distal end portion. The mouthpiece portion includes a capsule cavity and a mouthpiece air channel extending from the mouthpiece end to the capsule cavity. The distal end portion includes a piercing element coupled to the distal end portion and a resealable membrane configured to seal the capsule cavity when the mouthpiece portion is coupled to the distal end portion. The resealable membrane is configured to reseal when the piercing element moves out of the resealable membrane.

A cartridge for housing an aerosol-forming substrate includes a body with one or more walls having a wall opening; a cavity in the body in fluid communication with the at least one wall opening; and a cap rotatably connected to the body, where the cap is movable between a first position, in which the wall opening is exposed, and a second position, in which the wall opening is closed by the cap. The cap includes electrical connection points to selectively heat a portion of the contents of the cartridge.

A cartridge for housing an aerosol-forming substrate includes a body with one or more walls and a body opening. A cavity in the body is in fluid communication with the body opening. A cap may be removably and replaceably engaged with the body and may extend across the body opening. The cap may have a cap opening. A removable layer may be removably attached to the body and disposed between the body and the cap. A cartridge for housing an aerosol-forming substrate may include a body with one or more walls having a wall opening. A cavity in the body is in fluid communication with the at least one wall opening. A cap may be removably and replaceably engaged with the body and cover the wall opening.