In one embodiment, a method for manufacturing an aperture plate includes depositing a releasable seed layer above a substrate, applying a first patterned photolithography mask above the releasable seed layer, the first patterned photolithography mask having a negative pattern to a desired aperture pattern, electroplating a first material above the exposed portions of the releasable seed layer and defined by the first mask, applying a second photolithography mask above the first material, the second photolithography mask having a negative pattern to a first cavity, electroplating a second material above the exposed portions of the first material and defined by the second mask, removing both masks, and etching the releasable seed layer to release the first material and the second material. The first and second material form an aperture plate for use in aerosolizing a liquid. Other aperture plates and methods of producing aperture plates are described according to other embodiments.

A drug solution tank of the present invention is a drug solution tank for an ultrasonic inhaler, including a drug solution reservoir portion having an upper edge that surrounds an opening and a bottom portion formed so as to protrude downward, a flange portion formed so as to extend outward from the upper edge of the drug solution reservoir portion, and a leg portion that is continuous with the outer perimeter or lower surface of the flange portion, is formed so as to surround the drug solution reservoir portion, and extends downward past the bottom portion of the drug solution reservoir portion.

A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.

Embodiments of the disclosure include a system for administering a dosage of an inhalable product to a user including a vaporizing device for converting an active pharmaceutical ingredient (API) into the inhalable product to treat an affliction. The vaporizing device includes a communication element to send/receive at least one piece of dosage data to/from a portable electronic device, the dosage data corresponding to one or more properties of the dosage. The system also includes at least one processor and a memory. Memory includes machine-readable instructions that, when executed by the at least one processor, cause the system to receive an indicator corresponding to the API utilized by the vaporizing device, to determine the dosage for the API utilized by the vaporizing device, to transmit, to the user, instructions for administering the dosage, and to request feedback from the user regarding the efficacy of the dosage.

An example aerosol delivery device includes a mouthpiece having an airflow outlet, and an airflow passage extending between an airflow inlet and the airflow outlet. The example aerosol delivery device further includes a housing configured to receive a cartridge that includes an aerosolizable substance and a vapor element configured to heat the aerosolizable substance, and an internal power source configured to provide electrical power. The example aerosol delivery device further includes a controller coupled to the internal power source to receive a portion of the electrical power and configured to, when the cartridge is installed at the housing, cause the vapor element of the cartridge to heat the aerosolizable substance to release an aerosol into the airflow passage during an inhalation through the airflow outlet, and a connector configured to receive power from an external source to recharge the internal power source.

An fluid sensor to activate and control various components of an inhalation device. The fluid sensor includes an acoustic element, such as a microphone, positioned within said inhalation device to detect fluid within the device and output signals representative of the frequency, direction and/or amplitude of the fluid. These signals control and activate an electrostatic plate and/or a high frequency vibrator.

A mobile inhaler is provided and a container for using therewith. The mobile inhaler comprises: a mouthpiece comprising at least one inhaling opening; a body element connected to the mouthpiece and comprising a housing for holding a DC power source; a power conversion unit comprising an inverter operative to convert a DC voltage provided by a DC power source, into a higher AC voltage; a nebulizer comprising an ultrasonic vibrator and a mesh, wherein the ultrasonic vibrator is activated by the AC voltage, and wherein the nebulizer is adapted to enable converting into aerosol droplets at least part of a liquid comprised in an enclosure, and the aerosol droplets to be directly inhaled from the mouthpiece; and an enclosure adapted to enable holding a liquid, and characterized in that it provides a connection to enable fluid transfer from the enclosure to the nebulizer.

A vibrating mesh nebuliser. The nebuliser (100, 400, 500) comprises a cartridge section (110, 420, 520) comprising a reservoir (180) containing a liquid to be nebulised (190), a mouthpiece comprising a conduit (160), wherein a flow path (210) is defined between the reservoir (180) and the conduit (160) and whereby a user may inhale nebulised liquid from the mouthpiece through the conduit (160). The nebuliser further comprises a body section (120, 410, 510), releasably connectable to the cartridge section (110, 420, 520) and a mesh section (530) comprising a vibratable mesh (250, 540), the vibratable mesh (250, 540) being disposable in the flow path (210), so as to nebulise liquid drawn from the reservoir to the conduit in the mouthpiece. Also provided are an apparatus and method for monitoring one or more physiological responses to material self-administered by a user.

Novel nebulizers and methods are provided for a nebulizer including a dialable negative pressure threshold valve that actuates in response to different negative pressures corresponding to different negative pressure threshold settings of actuation of the valve to influence inhalation effort, aerosol entrainment, and aerosol delivery.

A mesh type atomizer according to an embodiment includes a porous thin film having a multi-hole structure, a metal layer covering a remaining area except a nozzle area in which droplets are sprayed through the holes on a surface of the porous thin film, and an ultrasonic transducer to output ultrasonic waves to vibrate the porous thin film. According to an embodiment, it is possible to atomize a liquid into nanometer-level fine particles using the porous thin film including nanometer sized holes. It is possible to precisely adjust the sprayed droplet size by setting the shape, size and cycle of the nozzle in the manufacturing process, and it is possible to selectively increase the strength of the mesh by growing the metal material in the hole of the porous thin film through electroplating.