An actuator (100) for an inhaler includes a sleeve (106) having a first end (102) and a second end (104). The sleeve is substantially hollow and defines a longitudinal axis (110) along its length. A base (108) is formed at the first end of the sleeve. A mouthpiece (112) is joined to the sleeve and the base. The mouthpiece is substantially hollow and defines a delivery opening (114). The actuator includes a cover (116) removably attached to the mouthpiece for covering the delivery opening. The actuator further includes a retaining member for retaining the cover to the sleeve upon removal of the cover from the mouthpiece. The retaining member includes a ring (120) disposed around the sleeve. The ring is at least selectively rotatable about the longitudinal axis and slidable along the longitudinal axis relative to the sleeve. The retaining member further includes a strap (122) extending from the ring and attached to the cover.

A method for estimating an inhale dose when a drug is delivered to a person using an inhaler is disclosed. A predicted inhale dose (PID) of the drug is estimated based on at least one first-type parameter and at least one second-type parameter. The first-type parameter is related to a breath pattern of the person, and the second-type parameter is related to the inhaler.

This invention provides a dosage form dispenser, comprising a casing comprising a first portion adapted for insertion within an oral cavity of a subject and a second portion adapted to encase a dosage form dispensing mechanism located therewithin; at least one camera positioned on said second portion of said casing, further positioned to capture a field of view of a portion of a face of a subject, wherein said field of view comprises at least a portion of a base view of the nose of said subject; a dosage form dispensing mechanism; a microprocessor and associated memory for processing and storing user authentication information, comparing images relayed from said at least one camera to at least one stored user standard and providing authentication when a match is established; and an interface connected to said dispensing mechanism, which promotes dispensing said dosage form when said authentication has been obtained. Methods for dispensing a dosage form directly within an oral cavity of a subject in need thereof, using the dispensers are also described.

The present disclosure presents systems, apparatuses, and methods of evaluating air quality sensor data. In this regard, a method comprises receiving air quality sensor data from a plurality of portable smart air quality measurement system (SAQMS) communication devices from a plurality of citizens in a geographic location; receiving air quality sensor data from an air quality measurement and calibration (AQMC) station in the geographic location; determining a level of resolution for one or more sensors of a portable SAQMS communication device at a central evaluation and measurement service; correcting air quality data received from the portable SAQMS communication device to compensate for the determined level of resolution at the central evaluation and measurement service; and generating a map of air quality data based on at least the corrected air quality data of the portable SAQMS communication device and a plurality of other portable SAQMS communication devices.

Provided is a system (10) for determining a probability of an asthma exacerbation in a subject. The system comprises an inhaler (100) for delivering a rescue medicament to the subject. The inhaler has a use-detection system (12B) configured to determine a rescue inhalation performed by the subject using the first inhaler. A sensor system (12A) is configured to measure a parameter relating to airflow during the rescue inhalation. The system further comprises a processor (14) configured to determine a number of the rescue inhalations during a first time period, and receive the parameter measured for at least some of the rescue inhalations. The processor determines, using a weighted model, the probability of the asthma exacerbation based on the number of rescue inhalations and the parameters.

The model is weighted such that the number of rescue inhalations is more significant in the probability determination than the parameters.

An inhaler with a mixing channel (1) for producing an aerosol to be inhaled includes an outlet (9) at one end that can be inserted in the mouth of a person in order to inhale the aerosol that is produced; at least one inlet (3) at its other end for drawing air into the mixing channel (1); and at least one injection zone (6) that lies between the inlet (3) and the outlet (9) and forms part of the channel wall. The injection zone (6) has at least one nozzle orifice (10) for supplying a liquid, especially a liquid drug, wherein the inner surface of the injection zone (6) is largely flush at least with that portion of the mean surface curvature (22) of the inner surface of the channel wall (11) that is adjacent to it on the inlet end. A possible height difference (17) between the inner surface of the injection zone (6) and that portion of the mean surface curvature (22) of the inner surface of the channel wall (11) that is adjacent to it is less than 1 mm or at most 100 μm or at most 20 μm.

An apparatus includes a simulated medicament delivery device and an electronic circuit system coupled to the simulated medicament delivery device. The electronic circuit system is configured to output an electronic output associated with a use of the simulated medicament delivery device.

The present invention relates to a kit comprising: a) an ampoule; b) a material comprising a hemp plant or parts thereof; and c) a color indicator capable of reacting by contacting the hemp plant and/or at least a part thereof to change the color of the color indicator, wherein the material and the color indicator are disposed in the ampoule; and a method for qualitatively and/or quantitatively detecting one or more substance(s) contained in the hemp plant using the kit.

Apparatus, methods, and kits for treating symptoms associated with common ailments, such as headaches, rhinitis, asthma, epilepsy, nervous disorders and the like, are provided. The apparatus comprises dispensers for carbon dioxide other therapeutic gases. The methods comprise delivering small volumes of these gases to patients in a manner where the gas infuses into a body region in order to bathe the mucous membranes therein. It has been found that even very short exposure of patients to small volumes and high concentrations of such gases can provide significant relief from symptoms.

A nasal fluid-spray device having: a reservoir containing at least one dose (D) of fluid; and a dispenser system that, each time the device is actuated, sprays a dose (D) of fluid through a spray orifice, generating a spray that extends axially from the spray orifice. The device further includes a generator system for generating a secondary flow, which generator system is actuated simultaneously with the dispenser system, the secondary flow generator system having a secondary flow channel provided with an outlet orifice, the outlet orifice arranged downstream from the spray orifice, and the secondary flow extending from the outlet orifice along an axis (B) that forms an angle (α) relative to the axis (A) of the spray and that intersects the axis (A), thereby deforming and/or deflecting the spray.