Systems and methods of an electronic drug delivery system for use in a treatment program (e.g., a smoking cessation program). The delivery system can include a mobile platform and a hand-held inhalation delivery device having a controller circuit coupled to a power source, sensors, aerosolizer drivers, and a rescue button, and a pod removably coupled to the delivery device. The delivery system generates an aerosol mixture from substances in the pod in accordance with the treatment program, and delivers the aerosol mixture for inhalation by a user. The controller circuit individually and dynamically controls the aerosolizer drivers to generate signals that drive a plurality of thermal, or non-thermal, aerosolizers of the pod to generate individually tailored aerosol mixtures from multiple substances in the aerosolizer pod. The generated aerosol mixtures can have various percentages of the substances, and have different aerosol droplet sizes during different portions of the treatment program.

A face engaging device such as a nozzle, facemask, etc., may include a housing including a fluid channel extending through the housing to an opening configured to be placed in fluid communication with the mouth of a user. The housing may include a first surface configured to be placed in contact with the skin of the user and a second surface exposed to the fluid channel. The face engaging device may also include a thermal actuator supported by the housing and including a first heat transfer surface position on the first surface, where the first heat transfer surface is configured to apply a thermal profile to the skin of the user when the opening is placed in fluid communication with the mouth of the user.

The present disclosure provides a method for the surface modification of microstructured components having a polar surface, in particular for high-pressure applications. According to the method, a microstructured component is contacted, in particular treated, with a modification reagent, wherein the surface properties of the component are modified by chemical and/or physical interaction of the component surface and of the modification reagent.

An inhalation spacer movable between a collapsed configuration and an expanded configuration. The spacer is made from paperboard having a bending stiffness of at least 2.5 mNm.

An inhaler (10) has a main body for accommodating a medicament reservoir (84), a canister fire system for moving a canister (50) to release a dose in response to air flow, a cap housing (12) for enclosing the canister fire system and canister within an interior chamber defined by the main body (14) and a cap housing, wherein a lock system (250) is provided for locking the cap housing on the main body.

Heads for an aerosol container are disclosed. The head comprises a handle body having a base configured to be coupled to the aerosol container, an outlet, a flexible tube housed within the handle body. The flexible tube is configured to provide fluid communication between the container exit of the aerosol container and the outlet. And the head further comprises an elastically deformable actuator comprising a lever arm, and a coupling portion integrally formed with the lever arm and configured to be mounted around the flexible tube, wherein the coupling portion is further configured such that when the lever arm is deformed by a user, the coupling portion actuates on the valve body of the aerosol container. Aerosol containers comprising such heads and kits for treatments skin lesions are also disclosed.

Some embodiments are directed to an adherence monitor for use with a tethered cap inhaler device. The adherence monitor engages the inhaler device, and includes a tether opening located within a housing of the adherence monitor for receiving the tether. The tether opening is in the form of a slot in a base portion of the housing. The path length of the tether around the adherence monitor is kept from being increased, compared to its path length when the adherence monitor is not attached to the inhaler, by having the slot located to allow the tether to pass through the slot. Various sensors of the adherence monitor in various embodiments detect inhaler usage.

A power supply unit for an aerosol inhaler includes: a power supply able to discharge power to a load for generating an aerosol from an aerosol source; a connector able to be electrically connected to an external power supply; a control device configured to control at least one of charging and discharging of the power supply or configured to be able to convert power which is input from the connector into charging power for the power supply; and a zener diode provided between the connector and the control device so as to be connected in parallel with the control device. A maximum value of zener voltage of the zener diode is lower than a maximum operation guarantee voltage of the control device.

A respiratory device comprising a housing enclosing a chamber and an orientation indicator moveable with respect to the housing between a first position indicative of an orientation of the housing predetermined to be suitable for operation of the respiratory device, and a second position indicative of an orientation of the respiratory device predetermined to be less suitable for operation of the respiratory device. The orientation indicator is positioned in a location on the respiratory device visible to a user during the operation of the respiratory device.

An inhalation-synchronized fluid dispenser device having a body (10; 10′) provided with a mouthpiece (400), a fluid reservoir (100) containing a fluid and a propellant gas being mounted to slide axially in the body (10; 10′), a metering valve (200) including a valve member (210) assembled on the reservoir (100) for selectively dispensing the fluid. The device includes an actuator element (500, 500′, 500″; 550) movable and/or deformable between a non-actuation position and an actuation position; an inhalation-controlled trigger system including an inhalation-sensitive member (60, 61; 65, 66) deformable and/or movable under the effect of inhaling and when deformed and/or moved, moving and/or deforming the actuator element (500, 500′, 500″; 550) from its non-actuation position towards its actuation position; an electronic dose counter (1000); and a signal-transmitter (1100) for communicating, in particular communicating remotely, information relating to the actuations of the device.