Concurrent treatment of obstructive sleep apnea and hypertension in a patient, via a pressure generating device, includes providing a flow of treatment gas to an airway of a patient in accordance with an initial set of flow parameters with respect to an obstructive sleep apnea mode. Responsive to determining that the patient has achieved stable breathing while receiving the flow of treatment gas, the flow parameters are increased above the initial set of flow parameters with respect to a hyper-ventilation mode. The flow of treatment gas is then provided to the airway of the patient in accordance with the increased flow parameters for a predetermined period of time. The increased flow parameters are configured to bring the patient's breath into accordance with target patient breath parameters configured to inflate the patient's lungs beyond a threshold for activating pulmonary stretch receptors of the airway of the patient.

The subject matter of the application is a device for adjustment and/or regulation of the CO.sub.2, carbon dioxide content of the inhaled air. Device based on the invention where a CO.sub.2 vessel 30 is connected to the CO.sub.2 input aperture 22, a measuring tool 15 determining the CO.sub.2 content of the exhaled air is connected to the exhaled air pipe 11, the output aperture of the measuring tool 15 is connected to the input aperture of a control unit 50, and the output aperture of the control unit 50 is connected to the valve 28 adjusting the blending rate of blending vessel 20 and so adjusting the CO.sub.2 content of the inhaled air.

An artificial ventilation system and relative control method, the ventilation system is suitable for application to CPAP (Continuous Positive Airway Pressure) breathing helmets to provide artificial ventilation to a patient with respiratory difficulties destined for so-called “sub-intensive” therapies. The artificial ventilation system provides a fully automated ventilation and does not require frequent checks by specialized medical personnel. The relative control method allows automatic control of the entire artificial ventilation system and implements innovative control strategies and techniques.

The invention relates to a ventilator (1), at least comprising a gas supply device (2) and a gas discharge device (3), for supplying a first fluid flow (4) to a respiratory tract (5) of a patient and for discharging a second fluid flow (6) from the respiratory tract (5) back into the ventilator (1) or to a surrounding area (7); a pressure sensor (8) for sensing a pressure (9) in the respiratory tract (5); and a control device (10) for operating the ventilator (1) and for determining an alveolar pressure P.sub.alv (9) and/or a profile of an alveolar pressure P.sub.alv (9) of a respiratory tract (5) of a patient. The invention also relates to a method for determining at least one alveolar pressure P.sub.alv (9) and/or a profile of an alveolar pressure P.sub.alv (9) of a respiratory tract (5) of a patient with a ventilator (1).

A device for capturing momentarily an exhaled breath of a COVID 19 patient containing active SARS-CoV-2 virions within an accessible compartment of said device and converting said active SARS-CoV-2 virions into far-UVC inactivated SARS-CoV-2 virions by exposure to an activated 222 nm far-UVC lamp mounted in said accessible compartment and with the next inhaled breath of said COVID 19 patient said far-UVC inactivated SARS-CoV-2 virions are positioned within the respiratory system ready to be captured by an antigen-presenting cells such as the Dendritic cells (DCs) which are antigen-presenting cells that capture, process, and present antigens to lymphocytes to initiate and regulate the adaptive immune response. Said far-UVC inactivated SARS-CoV-2 virions can be collected from said accessible compartment of said device and processed into viable vaccine that can be administered to front-line workers.

An apparatus and method for controlling the end tidal partial pressure of a gas X in a subject's lung, and to the use of such an apparatus and method for research, diagnostic and therapeutic purposes, wherein the method consists of: -obtaining input of a series of logistically attainable PetX values for a series of respective breaths: -determining an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX for each of said respective breaths; and controlling a gas delivery device to deliver the amount of gas in a volume of gas delivered to the subject in each of said respective breaths to target the respective PetX for that breath.

The present invention includes a device for hypoxia training comprising: one or more electrochemical cells each comprising: a cathode and an anode separated by a proton exchange membrane, each of the anode and cathode in communication with an input and an output, wherein the input of the cathode is in fluid communication with ambient air, and wherein the input of the anode is in fluid communication with a source of liquid water; a power supply connected to the one or more electrochemical cells; and a mask in fluid communication with the output from the cathode of the one or more electrochemical cells, wherein oxygen is removed from the ambient air during contact with the cathode when hydrogen ions separated from liquid water by a catalyst on the anode convert oxygen in the ambient air into water.

The disclosure provides a way to supplement the tidal volume delivered to the patient by a leaking re-breather when the delivered volume becomes less than that set by the ventilator (in either pressure-regulated or volume modes). This may be accomplished with a shunt—a gas conduit joining the non-patient side of the re-breather to the patient side. A low-resistance, plenum or a draw-over vaporizer may also be incorporated into the gas pathway. Such a device may include a housing with a movable partition separating an actuating side from a patient side. The housing includes a ventilator orifice for pneumatic communication between a ventilator and the actuating side and a patient orifice for pneumatic communication between the patient side and a patient. A shunt defines a bypass flow path from the actuating side and to the patient side when the moveable partition is at a maximal displacement towards the patient side.

Apparatuses and methods are disclosed for improving the Weight/Duration ratio of Self Contained Breathing Apparatuses (SCBAs) by decreasing the amount of fresh breathing gas required from the system by saving exhaled air that is low in carbon dioxide in a reservoir and reusing it at the subsequent inhalation. Electronic control units (“ECUs”) including conventional oxygen sensors and special types of carbon dioxide sensors are used to monitor and predictably regulate the consumption of breathing gas, further contributing to a significantly lower overall system weight for any given duration of the SCBA.

Provided herein are methods of treatment, including methods of treating subjects having or at risk of having or having a viral infection, and specifically a SARS-CoV-2 viral infection. The methods provided include the administration of 4-methylumbelliferone (4-MU), palmitoylethanolamide (PEA), reservatrol, fisetin, H.sub.2, nebulized hyaluronidase or combinations thereof. Also provided herein are a respiratory assistance device, methods of generating a customized respiratory assistance device, methods of treating a coronavirus infection, and methods of inhibiting a coronavirus infectivity, virulence and/or spread.