Methods, devices, and systems establish and facilitate retrograde or reverse flow blood circulation in the region of the carotid artery bifurcation in order to limit or prevent the release of emboli into the cerebral vasculature such as nto the internal carotid artery. The methods are particularly useful for interventional procedures, such as stenting and angioplasty, atherectomy performed through a transcarotid approach or transfemoral into the common carotid artery, either using an open surgical technique or using a percutaneous technique, such as a modified Seldinger technique or a micropuncture technique.

An apparatus for performing a medical procedure is provided. A catheter includes a tubular body having a plurality of markings indicative of a distance to an end portion of the catheter. A movable indicator repositionable on the tubular body to indicate a position of at least one of the plurality of markings. The indicator may also be provided with a magnifier for facilitating reading any indicia on the catheter.

Apparatus comprising: a flexible sleeve adapted to be slid over the exterior of an endoscope, wherein the endoscope comprises a proximal end and a distal end, and a handle disposed at the proximal end of the endoscope, and wherein the sleeve comprises a proximal end, a distal end and a sleeve lumen extending therebetween, and further wherein the sleeve is configured to be slid over the exterior of the endoscope so as to substantially cover the exterior of the endoscope from a point adjacent to the distal end of the endoscope to a point adjacent to the handle of the endoscope; a balloon secured to the distal end of the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with an interior of the balloon; and a pair of push tubes mounted to the sleeve.

Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; an aft balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the aft balloon; a pair of hollow push tubes slidably mounted to the sleeve, the pair of hollow push tubes being connected to one another at their distal ends with a raised push tube bridge, the raised push tube bridge being configured to nest an endoscope therein; and a fore balloon secured to the distal ends of the pair of hollow push tubes, the interior of the fore balloon being in fluid communication with the interiors of the pair of hollow push tubes, wherein the fore balloon is capable of assuming a deflated condition and an inflated condition, and further wherein (i) when the fore balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and (ii) when the fore balloon is in its inflated condition, the axial opening is closed down.

Described are methods, systems, devices for facilitation of intraluminal medical procedures within the neurovasculature. A catheter advancement device includes a flexible elongate body having a proximal portion coupled to a proximal end region of the flexible elongate body and extending proximally to a proximal-most end of the catheter advancement element. A hardness of the flexible elongate body transitions proximally towards increasingly harder materials up to the proximal portion forming a first plurality of material transitions. At least a portion of the flexible elongate body is formed of a plurality of layers including a reinforcement layer. An outer diameter of the flexible elongate body is sized to be positioned coaxially within a lumen of a catheter such that a distal tip portion of the flexible elongate body extends distally beyond a distal end of the catheter to aid in delivery of the catheter to an intracranial vessel.

Disclosed are puncture sealing systems and methods of locating a puncture site within a vessel. The systems can include elongated dilators and access sheaths that are configured to locate the puncture site within a vessel so that the position of the puncture site relative to a distal end of the access sheath is known during a puncture sealing procedure.

A double-lumen percutaneous femoral cannula for extracorporeal membrane oxygenation (ECMO) is an apparatus that is used to perform an ECMO procedure in non-ideal conditions. The apparatus may include at least one first cannula and at least one second cannula of different sizes that are arranged to form a single structure. By providing a single structure instead of several separate components, the apparatus makes the insertion of the apparatus easier and reduces the risk of the apparatus dislodging while the patient is being transported. The at least one first cannula and the at least one second cannula are preferably elongated tubular structures designed to prevent the recirculation of oxygenated blood. The at least one first cannula is designed to enable the aspiration of deoxygenated blood, while the at least one second cannula is designed to enable the pumping of oxygenated blood back into the body.

The invention relates to a microneedle array and to the use thereof for intradermal delivery, comprising a plurality of microneedles on a carrier, wherein this microneedle array is suitable for penetrating the skin of humans or animals and includes at least one color change indicator.

A catheter system having one or more needle position indicators to assist an operator in withdrawing the introducer needle to a “parked” position, as part of a catheterization procedure, wherein the needle position indicator provides a visual indication to the operator.

Systems and methods are provided for performing a treatment of a lesion within a subject using an endoscopic device. The endoscopic device comprises an endoscope and a catheter. The endoscope is configured to be inserted into the subject and includes a working channel. The catheter is configured to pass through the working channel of the endoscope. The catheter further comprises a sheath, an expandable device, and a light source. The sheath has a lumen and the expandable device may include an inflatable balloon. The light source is configured to be controllable through the lumen of the sheath. The light source is configured to selectively apply light to the lesion within the subject when the endoscope is inserted into the subject.