A method of manufacturing a cold plate includes forming a fluid circuit on a build surface in a layer-by-layer fashion from a build material. The fluid circuit includes a plurality of peripheral walls, each of the plurality of peripheral walls at least partially defining a primary channel, a longitudinally one of the peripheral walls being formed to include apertures configured to permit excess build material to pass therethrough. A central wall of the fluid circuit at least partially defines the primary channel and a plurality of secondary channels fluidly connected to the primary channel. The method further includes removing excess build material through the apertures.

A jetted binder printing system includes a carrier substrate configured to travel along a longitudinal direction thereof, an adjustable binder printer configured to deliver an adjustable binder to the carrier substrate, a dispensing module located downstream from the adjustable binder printer on the longitudinal direction of the carrier substrate, the dispensing module including at least one powder container, the dispensing module being configured to dispense powder onto the carrier substrate, and a primary binder printer located downstream from the compaction module along the longitudinal direction of the carrier substrate. The primary binder printer includes a print head configured to print a primary binder on the dispensed powder according to a desired pattern. The primary binder is printed on a surface of the powder that is opposite a surface on which the adjustable binder is printed. The primary binder is printed to match the pattern of the adjustable binder.

A three dimensional printing system, the system including: a printhead; and a removable tray comprising a reservoir, the tray located in a print bed of the three dimensional printing system such that liquid purged from the printhead is deposited in the reservoir, wherein prior to the system purging liquid from the printhead, the system confirms that the tray is in place using a sensor.

A three dimensional printing system, the system including: a printhead; and a removable tray comprising a reservoir, the tray located in a print bed of the three dimensional printing system such that liquid purged from the printhead is deposited in the reservoir, wherein prior to the system purging liquid from the printhead, the system confirms that the tray is in place using a sensor.

A method for producing a component layer-by-layer includes: providing two or more resin handling assemblies, each including a resin support which has at least a portion which is transparent, each resin support defining a build surface located in a build zone of the respective assembly; executing a build cycle, including: depositing on each build surface radiant-energy-curable resin, the resin on each build surface being a unique material combination; positioning a stage relative to one of the build surfaces to define a layer increment; selectively curing the resin using applied radiant energy so as to define a cross-sectional layer of the component; separating the component from the build surface; cleaning at least one of the component and the stage; and repeating the cycle, for a plurality of layers, wherein at least one of the layers is cured in each of the build zone. Apparatus is described for carrying out the method.

A method for producing a component layer-by-layer includes: providing two or more resin handling assemblies, each including a resin support which has at least a portion which is transparent, each resin support defining a build surface located in a build zone of the respective assembly; executing a build cycle, including: depositing on each build surface radiant-energy-curable resin, the resin on each build surface being a unique material combination; positioning a stage relative to one of the build surfaces to define a layer increment; selectively curing the resin using applied radiant energy so as to define a cross-sectional layer of the component; separating the component from the build surface; cleaning at least one of the component and the stage; and repeating the cycle, for a plurality of layers, wherein at least one of the layers is cured in each of the build zone. Apparatus is described for carrying out the method.

According to an example, a device comprises a sidewall and a base. The sidewall and the base define a chamber for receipt of a volume of build material comprising loose build material and a solid object generated from the build material in an additive manufacturing process. The base is not permeable to build material but permeable to a gas to allow an influx of a gas into the chamber to fluidize loose build material around the solid object in the volume of build material in the chamber to facilitate the removal of the solid object from the loose build material.

Disclosed herein are drug delivery devices that can temporally and spatially deliver biologically active agents. An example drug delivery device includes a microneedle array comprising a plurality of microneedles on a surface of a substrate, each microneedle comprising a core comprising a hydrogel and a layer on a surface of the core. Also disclosed are methods of using the drug delivery device, and methods of making the microneedle array that includes a loading device.

Disclosed herein are drug delivery devices that can temporally and spatially deliver biologically active agents. An example drug delivery device includes a microneedle array comprising a plurality of microneedles on a surface of a substrate, each microneedle comprising a core comprising a hydrogel and a layer on a surface of the core. Also disclosed are methods of using the drug delivery device, and methods of making the microneedle array that includes a loading device.

The present disclosure provides three-dimensional (3D) objects, 3D printing processes, as well as methods, apparatuses and systems for the production of a 3D object. Methods, apparatuses and systems of the present disclosure may reduce or eliminate the need for auxiliary supports. The present disclosure provides three dimensional (3D) objects printed utilizing the printing processes, methods, apparatuses and systems described herein.