A mask according to an embodiment comprises: a first substrate disposed on a first base layer; a first wire disposed on the first substrate; a piezoelectric element disposed on the first wire; a second wire disposed on the piezoelectric element; a second substrate disposed on the second wire; a second base layer disposed on the second substrate; and a cavity disposed between the first base layer and the piezoelectric element, wherein the cavity is disposed in a region overlapping the piezoelectric element in a vertical direction.

Apparatuses and methods configured to provide heat and cold to the skin along with a skin treatment to control rate of skin treatment flow to the skin are described. The disclosed apparatuses and methods include beneficially delaying the transition of skin treatments once skin penetration is achieved to improve the effectiveness of topical treatments to the skin. Accordingly, the disclosed apparatuses and methods are configured to enhance the benefits of topical treatments to the skin.

Disclosed herein are systems and methods for providing a portable magnetic field therapy system for inducing an effect of a chemical or biochemical agent to a mammalian subject, such as for the treatment of diseases and adverse health conditions.

An LED patch for a skin care apparatus is provided. An LED patch for a skin care apparatus according to an exemplary example of the present invention comprises: a substrate part; a circuit pattern part formed in at least two layers on the substrate part; a light source part including one or more LEDs mounted on one surface of the substrate part; and a cover part configured to cover at least one surface of the substrate part.

Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.

The present invention provides rapid-acting insulin and insulin analogue formulations. The invention further provides delivery devices, particularly infusion sets, which allow for the rapid absorption of insulin and insulin analogues, as well as other active agents. Methods of using the insulin and insulin analogue formulations as well as the insulin delivery devices for treating subjects with diabetes mellitus are also provided.

A gas-evolving composition delivery system is disclosed, which comprises a pressurized container having a dispenser, and a liquid gas-evolving composition, such as an acidified nitrite solution, within the pressurized container, wherein the pressurized container has an internal pressure sufficient to minimize gas production from the gas-evolving composition while within the container. Also disclosed is a method of stabilizing an acidified nitrite solution comprising loading the solution into a container and sealing the container to be airtight.

The present specification disclosed a noninvasive transdermal delivery device that relates generally to a handheld mechanical apparatus for noninvasive transdermal administration of gas, small to large water-soluble (hydrophilic) pharmaceutical agents, vitamins, and other therapeutic agents. Components of such delivery devices, methods of producing a substance comprising a supersaturated amount of a dissolved gas, as well as, methods of administering a therapeutic agent using such delivery devices and methods of treating a disease or condition using such delivery devices are also disclosed.

Exemplary embodiments of a method, device, and apparatus for positioning an apparatus on a location of a tissue. For example, a substantially rigid film over an area of tissue to be treated can be provided. The film can include a positioning arrangement that facilitates a particular spatial engagement with the apparatus. The exemplary method can further include applying a portion of the film to a portion of a surface of the tissue and positioning the apparatus at the location by the engagement of the film to the apparatus using the feature of the film.

Systems, devices, and methods are described for providing a cosmetic device configured to deliver an active component into a skin and a method for manufacturing such a cosmetic device. In an embodiment, the cosmetic device includes an anisotropic magnetic element located in or on the head part of the body and configured to generate a magnetic field which induces diamagnetism in the active component. In an embodiment, the anisotropic magnetic element has a honeycomb magnetization pattern.